Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.

In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12% (p = 0.003, log-rank test), while meclizine (Mec), an mTORC1 inhibitor, extended the male lifespan by 8% (p = 0.03).

Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease.

Oxidative stress and inflammation are implicated in several different manifestations of cardiovascular disease (CVD). They are generated, in part, from the overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) that activate transcriptional messengers, such as nuclear factor-kappaB, tangibly contributing to endothelial dysfunction, the initiation and progression of atherosclerosis, irreversible damage after ischemic reperfusion, and even arrhythmia, such as atrial fibrillation. Despite this connection between oxidative stress and CVD, there are currently no recognized therapeutic interventions to address this important unmet need.

Anatomic study of the ulnar nerve and related vascular anatomy at Guyon's canal: a practical classification system.

Thirty-one fresh adult upper extremities were microdissected in order to delineate the regional anatomy of the ulnar nerve and artery at the wrist. Two patterns of division of the ulnar nerve trunk were identified: A and B. Three patterns of hypothenar muscle innervation-type 1, 2, and 3- and two patterns of vascular supply to the hypothenar musculature-type 1 and 2-were also identified.

Comparison of rigid plate versus wire fixation in the management of zygoma fractures: a long-term follow-up clinical study.

We evaluated retrospectively 101 patients to assess clinically the results of fixation methods on isolated unilateral zygoma fractures (mean follow-up 3.2 years). All patients were examined by an investigator who was blinded to the initial fixation method.

Muscle recruitment variations during wrist flexion exercise: MR evaluation.

Objective: Many exercise protocols used in physiological studies assume homogeneous and diffuse muscle recruitment. To test this assumption during a "standard" wrist flexion protocol, variations in muscle recruitment were assessed using MRI in eight healthy subjects.

Materials And Methods: Variations were assessed by comparing the right to the left forearms and the effect of slight (15 degrees) pronation or supination at the wrist.

Muscle proton T2 relaxation times and work during repetitive maximal voluntary exercise.

We studied the effects of progressive maximal voluntary handgrip contractions (MVCs) on muscle proton spin-spin (T2) relaxation times and work, measured as the integrated force vs. time curve (FTI). Six healthy volunteers performed 10, 20, 40, and 80 MVCs in a 0.

Soft tissue coverage for the upper extremity.

Soft tissue coverage of the upper extremity continues to be a challenging and evolving field. The expeditious and reliable methods of soft tissue coverage currently in use are discussed with reference to their shortcomings and advantages. For soft tissue coverage of fingertip injuries, open treatment or local flaps from the hand remain the mainstay of treatment.

Denervated human skeletal muscle: MR imaging evaluation.

Because determination of neurologic integrity after severe limb trauma is crucial in patient care, the authors assessed magnetic resonance (MR) imaging as a tool to map denervated motor units of skeletal muscle in patients with traumatic peripheral neuropathy. Denervation was confirmed in 22 patients with use of electromyography, surgery, or both. MR imaging was performed with moderately T1- and T2-weighted spin-echo and short-tau inversion-recovery (STIR) sequences.

Finger-specific flexor recruitment in humans: depiction by exercise-enhanced MRI.

To evaluate the spatial distribution of human forearm musculature stressed by finger-specific exercise, magnetic resonance imaging was performed in conjunction with exercise protocols designed to separately stress the flexor digitorum superficialis and flexor digitorum profundus. These muscles were shown to consist of subvolumes selectively recruited by flexion of the individual fingers. Knowledge of the finger-specific regions of muscle recruitment during finger flexion could improve sampling accuracy in electromyography, biopsy, magnetic resonance spectroscopy, and invasive vascular sampling studies of hand exercise.

Optimizing the management of orbitozygomatic fractures.

Our understanding of the biomechanics and current management of orbitozygomatic fractures has evolved with the development of craniomaxillofacial surgery. Early management was minimal, with reduction alone as the uniform treatment, and the only variation was the approach used. However, a critical review of the literature using these methods revealed that many of these fractures were unstable after simple reduction alone.

The effect of vitamin C on the rapid induction of aortic changes in rabbits.

Male rabbits were injected intraperitoneally for five consecutive days with one of the following: (A) 0.3 ml/kg dimethyl ethylene glycol (solvent); (B) 40 mg/kg cholesterol and 8 mg/kg ergocalciferol in solvent; (C) same regimen as B with the addition of 150 mg/kg ascorbic acid in water. Daily blood samples were taken for determination of cholesterol and triglycerides, and for lipoprotein electrophoresis.