Publications by authors named "Watson Hua-Sheng Tseng"
Background: Both the basal metabolic rate (BMR) and excess postexercise oxygen consumption (EPOC) can be influenced by physical training and are associated with body composition and aerobic capacity. Although a correlation between the two is expected, this relationship has not been explored. Our hypothesis is that a higher BMR is correlated with lower EPOC.
View Article and Find Full Text PDFArticle Synopsis
- Frailty is a common syndrome in older adults, linked to poor health outcomes and assessed using the Frailty Phenotype (FP) and Frailty Index (FI), but its biological mechanisms are still not well understood.
- Researchers analyzed genetic and health data from UK Biobank participants (aged 60-73), identifying significant genetic links to frailty, including notable associations with known genes related to aging and metabolism.
- The study utilized machine learning to create models that effectively distinguish between frail and non-frail individuals, achieving a high accuracy of 85%, highlighting the polygenic nature of frailty and its connections to cognitive function and cholesterol metabolism.
Ferroptosis is a novel form of iron-dependent cell death characterized by lipid peroxidation. While the importance and disease relevance of ferroptosis are gaining recognition, much remains unknown about its interaction with other biological processes and pathways. Recently, several studies have identified intricate and complicated interplay between ferroptosis, ionizing radiation (IR), ATM (ataxia-telangiectasia mutated)/ATR (ATM and Rad3-related), and tumor suppressor p53, which signifies the participation of the DNA damage response (DDR) in iron-related cell death.
View Article and Find Full Text PDF