Publications by authors named "Watayagorn Thepsawat"
Engineered nanobodies (VHs) to the SARS-CoV-2 receptor-binding domain (RBD) were generated using phage display technology. A recombinant Wuhan RBD served as bait in phage panning to fish out nanobody-displaying phages from a VH/VH phage display library. Sixteen phage-infected clones produced nanobodies with 81.
View Article and Find Full Text PDFRNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this protein. Therefore, the RdRp is an attractive target for a broadly effective therapeutic agent against RNA viruses.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers created human single-chain antibodies (HuscFvs) specifically for the SARS-CoV-2 3CL protease using phage display technology, aiming to inhibit the enzyme's activity.
- * These engineered "superantibodies" effectively blocked the 3CL activity, demonstrated no toxicity to human cells, and successfully inhibited various SARS-CoV-2 variants, indicating their potential for clinical use.