The Impact of Eribulin on Stathmin Dynamics and Paclitaxel Sensitivity in Ovarian Cancer Cells.

Eribulin, an inhibitor of microtubule dynamics, is used for treating breast cancers and sarcomas. The microtubule-destabilizing protein stathmin may modulate the antiproliferative activity of eribulin on breast cancer cells and leiomyosarcoma cells. The antitumor activity of eribulin in ovarian cancers has not been fully explored, so the present study aimed to determine the antitumor efficacy of eribulin and the involvement of stathmin in ovarian cancers.

Control of structural redundancy from the head to trunk in the human upright standing revealed using a data-driven approach.

The human being dynamically and highly controls the head-trunk with redundant mechanical structures to maintain a stable upright standing position that is inherently unstable. The posture control strategies are also affected by the differences in the conditions of sensory inputs. However, it is unclear how the head-trunk segmental properties are altered to respond to situations that require appropriate changes in standing posture control strategies.

Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain.

GPR85 is a member of the G protein-coupled receptor and is a super-conserved receptor expressed in the brain sub-family (Super Conserved Receptor Expressed in Brain; SREB) with GPR27 and GPR173. These three receptors are "orphan receptors"; however, their endogenous ligands have not been identified. SREB has garnered the interest of many scientists because it is expressed in the central nervous system and is evolutionarily conserved.

Minimizing scattering-induced phase errors in differential interference contrast microscopy.

Significance: Differential interference contrast (DIC) microscopes allow noninvasive in vivo observation of transparent microstructures in tissue without the use of fluorescent dyes or genetic modification. We show how to modify a DIC microscope to measure the sample phase distribution accurately and in real-time even deep inside sample tissue.

Aim: Our aim is to improve the DIC microscope's phase measurement to remove the phase bias that occurs in the presence of strong scattering.

HVGH: Unsupervised Segmentation for High-Dimensional Time Series Using Deep Neural Compression and Statistical Generative Model.

Humans perceive continuous high-dimensional information by dividing it into meaningful segments, such as words and units of motion. We believe that such unsupervised segmentation is also important for robots to learn topics such as language and motion. To this end, we previously proposed a hierarchical Dirichlet process-Gaussian process-hidden semi-Markov model (HDP-GP-HSMM).

Erratum: Video-rate quantitative phase analysis by a DIC microscope using a polarization camera: errata.

[This corrects the article on p. 1273 in vol. 10, PMID: 30891345.

Video-rate quantitative phase analysis by a DIC microscope using a polarization camera.

This paper describes how to take advantage of the replacement of an intensity camera with a polarization camera in a standard differential interference contrast (DIC) microscope. Using a polarization camera enables snapshot quantitative phase analysis so that real-time imaging of living transparent tissues become possible. Using our method, we quantify the phase measurement accuracy using a phantom consisting of glass beads embedded in lacquer.

Generating action descriptions from statistically integrated representations of human motions and sentences.

It is desirable for robots to be able to linguistically understand human actions during human-robot interactions. Previous research has developed frameworks for encoding human full body motion into model parameters and for classifying motion into specific categories. For full understanding, the motion categories need to be connected to the natural language such that the robots can interpret human motions as linguistic expressions.

Regulation of muscular glutamate metabolism by high-protein diet in broiler chicks.

The major taste active component, glutamate (Glu), improves the taste of meat. In this study, we investigated the effect of a short-term high-protein (HCP) diet on the intramuscular free Glu content to improve the taste of meat. Furthermore, we elucidated how the muscle free Glu content was controlled by the HCP diet.