Benefits of a straight laparoscopic restorative proctocolectomy with ileal pouch anal anastomosis for ulcerative colitis: a retrospective case-matched study.

Purposes: The aim of this study was to evaluate the benefit of straight laparoscopic restorative proctocolectomy (sLRP) with ileal pouch anal anastomosis for ulcerative colitis (UC).

Methods: Twenty patients underwent sLRP or open restorative proctocolectomy. The 2 groups were retrospectively well matched with respect to sex, body mass index, and American Society of Anesthesiologists' score.

Laparoscopic resection of a gastrointestinal stromal tumor of the rectum after treatment with imatinib mesylate: report of a case.

This report describes the laparoscopic resection of a rectal GIST after treatment with imatinib mesylate. A 56-year-old male presented with a submucosal tumor (longest diameter, 8 cm) arising in the lower rectum. A core needle biopsy revealed that the tumor contained bundles of spindle-like cells.

Short- and long-term outcomes of laparoscopic surgery in patients with pathological stage II and III colon cancer.

Background/aims: In Japan, the safety and long-term outcomes of laparoscopic surgery for advanced colorectal cancer remains a matter of debate. We studied the safety and outcomes of laparoscopic surgery in patients with pathological stage II and III colon cancer.

Methodology: The study group comprised 253 patients with colon cancer who underwent laparoscopic surgery from January 1998 through December 2006.

Oncological outcomes of laparoscopic surgery in elderly patients with colon cancer: a comparison of patients 64 years or younger with those 75 years or older.

Background/aims: We compared the results of laparoscopic resection of colon cancer between patients 75 years or older and those 64 years or younger, to confirm whether this procedure is warranted in elderly patients.

Methodology: The study group was comprised of patients with stage I to III colon cancer treated by laparoscopic surgery from 1995 through 2006. Oncologic outcomes were compared between 74 patients 75 years or older (elderly group) and 74 patients 64 years or younger (younger group) who were matched for gender, tumor location and pathological tumor-node-metastasis (TNM) stage.

Successful laparoscopic resection of a sacrococcygeal teratoma in an adult: report of a case.

Sacrococcygeal teratoma is a relatively rare congenital retroperitoneal tumor in adults. The standard treatment is a complete tumor resection. This report describes the successful laparoscopic resection of a sacrococcygeal teratoma.

Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.

Purpose: Genetic alterations that are closely associated with patient prognosis can be landmarks of definitive therapeutic targets as well as useful biomarkers in human cancer clinics.

Methods: Three hundred seventy-eight colorectal cancer (CRC) patients were examined for K-ras mutations by single-strand conformation polymorphism (SSCP), with a subsequent 144 young colon cancer (YCC) patients added to validate its prognostic significance.

Results: K-ras mutations were identified in 161 (43%) of the 378 CRC patients and were significantly associated with tumor location (colon vs.

Retrospective, matched case-control study comparing the oncologic outcomes between laparoscopic surgery and open surgery in patients with right-sided colon cancer.

Purpose: The short- and long-term outcomes of laparoscopic surgery for right-sided colon cancer remain largely uninvestigated. This study was undertaken to compare the morbidity and mortality after either a laparoscopic right hemicolectomy (LRHC) or an open right hemicolectomy (ORHC) for this type of tumor.

Methods: The study group included 100 patients who underwent an LRHC and 100 patients who underwent an ORHC for right-sided colon cancer from 1990 through 2004.

Analysis of the risk factors for wound infection after surgical treatment of colorectal cancer: a matched case control study.

Background/aims: The present study, with a matched case-control study design, was undertaken to evaluate the usefulness of high-pressure washing for preventing postoperative wound infection by comparing the outcomes in cases in which the high-pressure washing was performed with those in which the procedure was not adopted.

Methodology: A total of 100 of the above-mentioned 264 patients were selected for this study and divided into two groups (the high- pressure washing group (n=50) and the non-high pressure washing group (n=50)) in such as manner as to obtain good matching of the following 6 parameters between the two groups.

Results: Postoperative wound infection was noted in 11% of all cases (11/100).

Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9.

Phosphatase of regenerating liver (PRL)-3 was identified as a molecule associated with liver metastasis in colorectal cancer (CRC), although its precise causative role in distant metastasis remains elusive from a clinical point of view. The aim of this study was to promote the mechanistic insight of PRL-3 involvement in liver metastasis in CRC. One hundred and seven CRC patients with resection of the primary lesions were studied for clinicopathological and prognostic association with PRL-3 and were evaluated by immunohistochemistry in univariate and multivariate analyses.

Diminishing impact of preoperative carcinoembryonic antigen (CEA) in prognosis of Dukes' C colorectal cancer.

Background: In curable colorectal cancer (CRC), preoperative serum carcinoembryonic antigen (CEA) (preCEA) has been reported to have predictive prognostic value. However, data remains insufficient to support its clinical use. The aim of the current study was to validate the prognostic impact of preCEA in Dukes' C CRC.

Risk factors for wound infection after surgery for colorectal cancer.

Background: Among complications after surgery for colorectal cancer, wound infections may prolong hospitalization and increase healthcare costs. This study was designed to clarify the incidence, risk factors, and pathogens responsible for wound infections after surgery for colorectal cancer.

Methods: The study group comprised 144 patients (94 men and 50 women) with colorectal cancer in whom the same surgeon at Kitasato University Hospital performed resection from January 2004 through December 2005.

Gastrointestinal stromal tumor of the rectum resected by laparoscopic surgery: report of a case.

A 53-year-old man visited our hospital with the chief complaint of pain on urination. On digital rectal examination, a rigid immobile tumor mass with a smooth surface was palpated on the anterior wall on the right side of the rectum near the anal canal. Computed tomography (CT) and magnetic resonance imaging (MRI) of the pelvis revealed a heterogeneous tumor mass measuring 6.

[Neoadjuvant chemoradiation therapy for locally advanced rectal cancer].

Not only the improvement of overall survival, but also the control of local recurrence, a unique type of recurrence, is an important issue in the treatment of advanced local rectal cancer. Total mesorectal excision is internationally accepted to be a standard procedure that lowers the rate of local recurrence. In 1999, the National Institutes of Health in the United States recommended "resection plus postoperative chemoradiotherapy" as the standard treatment for pathological stage II and III rectal cancer.

Comparison between the oncologic outcome of laparoscopic surgery and open surgery for T1 and T2 rectosigmoidal and rectal carcinoma: matched case-control study.

Background/aims: The long-term outcome of laparoscopic resection (Lap-R) of rectal cancer is still unclear. The purpose of this study was to elucidate the validity of Lap-R by comparing the short-term and mid-term outcome of Lap-R performed in our hospital to treat T1 and T2 rectal cancer patients with that of patients with the same clinicopathological background treated for rectal cancer by open surgery (O-R).

Methodology: We conducted a matched case-control study of the oncologic outcome of T1 and T2 rectal cancer patients who had undergone Lap-R between 1996 and 2002 by matching them for sex, age, location, and TNM classification with patients who underwent O-R during the same period, and the total number of subjects in both groups combined was 76.