Publications by authors named "Watanabe T"

Digestibility is an important characteristic of rice starch. It is affected by the growing environment, such as temperature and soil, so that even in the same genetic cultivar the digestibility of each product will be different. Here, we predicted rice starch digestibility by Raman scattering spectroscopy.

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Currently, taste sensors utilizing lipid polymer membranes are utilized to assess the taste of food products quantitatively. During this process, it is crucial to identify and quantify basic tastes, e.g.

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Article Synopsis
  • The study evaluated the health-related quality of life (QOL) in 10-year survivors of chronic kidney disease (CKD) in Japan, highlighting the impact of CKD and cardiovascular disease (CVD) on their well-being.
  • Data was collected from 1,473 participants using the EQ-5D-5L instrument, with a response rate of 38.2%, revealing a mean QOL score of 0.893 and demonstrating variations based on treatment status and CVD presence.
  • Significant factors influencing QOL included baseline age, blood pressure, and a history of hyperuricemia, indicating that CKD complications substantially impact long-term survivors' quality of life.
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Unlabelled: A 74-year-old man who had undergone surgical aortic valve replacement with the SOLO SMART stentless bioprosthetic valve 25 mm (LivaNova PLC, London, UK) and mitral valve replacement with MOSAIC 29 mm (Medtronic, Minneapolis, USA) 4 years previously was diagnosed with congestive heart failure, and transferred to our hospital. Echocardiography revealed severe aortic regurgitation caused by degraded bioprosthetic valve. He required continuous dobutamine administration to maintain hemodynamics.

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Unlabelled: In patients with a history of antithrombin deficiency, a direct thrombin inhibitor may be considered as an alternative to intraprocedural anticoagulation. A 55-year-old woman with antithrombin deficiency and prior myocardial infarction suffered from electrical storm and appropriate defibrillator shocks. Substrate mapping guided left ventricular endocardial and epicardial ablations were successfully performed.

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Background: The coronavirus disease 2019 (COVID-19) pandemic was reported to have increased depression among university students which was associated with impairments in their campus lives. This study examined changes in depressive states among Japanese university students during the COVID-19 pandemic.

Methods: A secondary data analysis from a factorial randomized controlled trial involving smartphone-based cognitive-behavioral therapy was performed.

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Pulmonary vein stenosis (PVS) is a serious complication of catheter ablation (CA) for atrial fibrillation (AF). PVS generally occurs several months after CA and presents with non-specific symptoms and imaging findings. There have been reports of delayed diagnoses due to a misdiagnosis as infection, interstitial pneumonia, or organizing pneumonia.

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Ninjinyoeito (NYT), a traditional Japanese medicine, is effective for improving physical strength and treating fatigue and anorexia. Recently, a clinical report revealed that NYT ameliorates cognitive dysfunction in Alzheimer's disease (AD) patients, although the mechanisms remain unclear. AD is a neurodegenerative disorder accompanied by a progressive deficit in memory.

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Juvenile myelomonocytic leukemia (JMML), which is classified as a myelodysplastic/myeloproliferative neoplasm, is a rare hematologic malignancy of childhood. Most patients with JMML require allogeneic hematopoietic cell transplantation (HCT) as a curative therapy. A Japanese retrospective analysis demonstrated favorable outcomes for a busulfan (BU) + fludarabine (FLU) + melphalan (MEL) regimen, with an overall survival (OS) of 72% and an event-free survival (EFS) of 53%.

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Background: Post-implant right heart failure (RHF) has been recognized as a crucial prognostic factor in patients receiving left ventricular assist devices (LVADs), and its management has long attracted attention from cardiologists and surgeons.

Case Presentation: This report described an 18-year-old female with acutely deteriorating heart failure due to dilated cardiomyopathy who underwent paracorporeal pulsatile-flow LVAD and developed early post-implant RHF. At postoperative day (POD) six, she was almost asymptomatic at rest on 2.

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Background: Morphological involvement of endocrine glands, such as the pituitary gland, remain uninvestigated in dogs with canine visceral leishmaniasis. Therefore, this study investigated the presence of amastigotes of spp. and characterized inflammatory changes, highlighting the involvement of TCD3 lymphocytes in different regions of the pituitary gland of dogs.

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Background: Intraorbital arteriovenous fistula (IOAVF) is a rare type of intracranial fistula that presents with ocular signs similar to those of cavernous sinus dural arteriovenous fistula. The treatment of IOAVF is based on the vascular architecture of each case due to its infrequent occurrence. The authors report the case of an IOAVF that was successfully treated with embolization via the facial vein, with good outcomes.

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Article Synopsis
  • Differentiation therapy shows potential for treating acute myeloid leukemia (AML), but effective methods that work across different AML subtypes are needed.
  • The study reveals that inhibiting a specific regulatory element of FOXO genes can induce differentiation in AML cells, identifying TRIB1 as a key gene that keeps these cells undifferentiated.
  • A new therapeutic approach combining a DNA-binding inhibitor with a chemotherapy drug effectively reduced TRIB1 levels, leading to AML cell differentiation and inhibiting tumor growth in animal models without significant side effects.
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Background/aim: Immune checkpoint inhibitors (ICIs) are currently a standard treatment tool for non-small cell lung cancer (NSCLC). RNA-binding motif protein 17 (RBM17), a splicing factor, is frequently over-expressed in NSCLC, but little is known about the role of RBM17 in the efficacy of ICIs for NSCLC. Thus, we investigated the correlation between RBM17 expression and ICI efficacy in NSCLC.

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We investigated humoral immune responses in 222 unvaccinated Japanese people after recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 2021. Anti-spike-protein IgG antibody levels and neutralizing antibody titers were measured in serum samples obtained within 20-180 days after diagnosis. The geometric mean of antibody titers was 1555 ELU/mL (95% confidence interval (CI) = 1257-1923), and the neutralizing activity (50% inhibitory dilution) was 253 (95% CI = 204-313).

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High-grade gliomas present a significant challenge in neuro-oncology because of their aggressive nature and resistance to current therapies. Boron neutron capture therapy (BNCT) is a potential treatment method; however, the boron used by the carrier compounds-such as 4-borono-L-phenylalanine (L-BPA)-have limitations. This study evaluated the use of boron-conjugated 4-iodophenylbutanamide (BC-IP), a novel boron compound in BNCT, for the treatment of glioma.

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Precision walking (PW) incorporates precise step adjustments into regular walking patterns to navigate challenging surroundings. However, the brain processes involved in PW control, which encompass cortical regions and interregional interactions, are not fully understood. This study aimed to investigate the changes in regional activity and effective connectivity within the frontoparietal network associated with PW.

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Purpose: Taking a short rest after lunch suppresses increases in blood flow to the digestive organs and maintains blood flow to the brain in the afternoon, possibly providing beneficial effects in preventing post-prandial drowsiness. The present study investigated sex-dependent influences on changes in hemodynamics produced by taking a short rest after lunch.

Methods: Subjects comprised 20 healthy young adults (10 men, 10 women; mean age 21 ± 1 years).

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Background: The frequency and prognosis of positive peritoneal washing cytology (CY1) in resectable pancreatic ductal adenocarcinoma (R-PDAC) remains unclear. The objective of this study was to identify the clinical implications of CY1 in R-PDAC and staging laparoscopy (SL).

Methods: We retrospectively analyzed 115 consecutive patients with R-PDAC who underwent SL between 2018 and 2022.

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Article Synopsis
  • A Phase II trial was conducted to evaluate the effectiveness and tolerability of low-dose gemcitabine plus nab-paclitaxel (GnP) in elderly patients with metastatic pancreatic cancer compared to the standard-dose treatment.
  • A total of 60 patients aged 65 or older were randomly assigned to receive either low-dose or standard-dose GnP, with the lower dose showing a significant reduction in the need for dose adjustments.
  • Overall, both treatment groups had similar efficacy results in terms of response rate, progression-free survival, and overall survival, but the low-dose regimen did not lead to a decrease in treatment-related adverse events.
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Optimal conditions for wound healing require a smooth transition from the early stage of inflammation to proliferation, and during this time alternatively activated (M2) macrophages play a central role. Recently, heat-killed lactic acid bacteria (LAB), such as Lactobacillus plantarum (L. plantarum) have been reported as possible modulators affecting the immune responses in wound healing.

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Article Synopsis
  • The red blood cell distribution width-albumin ratio (RAR) has been identified as a potential prognostic factor for adverse outcomes in various health conditions, but its relationship with chronic kidney disease (CKD) outcomes needed investigation.
  • In a study of 997 CKD patients, those with higher RAR values exhibited a significantly increased risk of progressing to end-stage kidney disease (ESKD), particularly in the higher RAR categories.
  • The study concluded that RAR may serve as a reliable and convenient marker for predicting renal prognosis in patients with CKD, proving to be more effective than the red cell distribution width (RDW).
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