Publications by authors named "Wasserbauer M"
Article Synopsis
- The study aimed to investigate the presence and risk factors of neurological extraintestinal manifestations, particularly peripheral neuropathy, in patients with severe Crohn's disease undergoing anti-TNFα therapy.
- Clinical examinations and lab tests were conducted on 30 neurologically asymptomatic patients, revealing that 36.7% had pathological results in sensor-motor function tests, with significant associations to age, disease duration, and BMI.
- The presence of cardiovascular autonomic neuropathy was found in 56.7% of patients, but no significant risk factors were identified, highlighting the need for further research on the neuropathic effects of Crohn's disease.
Purpose: Fecal immunochemical test (FIT) once a year or colonoscopy once in 10 years is the option approved for colorectal cancer (CRC) screening for asymptomatic individuals aged ≥ 50 years in the Czech Republic. We analyzed participation in the screening program to determine possible improvements.
Methods: In this observational cross-sectional study, data were collected from 4044 randomly chosen individuals from the Czech population (1866 men, 2178 women) aged ≥ 50 years by questionnaires.
Background And Aims: SARS-CoV-2 is a worldwide serious health problem and vaccination seems to have a crucial role in managing the COVID-19 pandemic. The aim of this prospective observational study was to monitor the trend of antibodies against SARS-CoV-2 after vaccination with BNT162b2 (COMIRNATY) in patients with inflammatory bowel disease treated by immunosuppressive and/or biological therapy, demonstrate whether any type of this therapy is associated with poorer production of antibodies against COVID-19 and evaluate the safety of vaccination against COVID-19 in these patients.
Methods: Eighty-seven eligible patients from one tertiary gastroenterological center with inflammatory bowel disease (60 with CD, 27 with UC) treated by immunosuppressive and/or biological therapy from the antiTNFα group were indicated to vaccination against SARS-CoV-2.
Article Synopsis
- The study aimed to assess the effectiveness and safety of adalimumab biosimilars FKB327 and GP2017 in treating patients with inflammatory bowel disease (IBD), focusing on Crohn's disease (CD) and ulcerative colitis (UC).
- Of the 50 patients treated, 73.5% with CD achieved remission after 12 weeks, while only 18.8% of UC patients reached remission; overall improvements in disease activity and lab results were noted.
- Seven adverse events were reported, leading to three cases where therapy was discontinued, indicating that while effective, the treatment has potential side effects.
Purpose: To investigate computed tomography (CT) features which predict lung resection in children with complicated community-acquired pneumonia.
Methods: A retrospective study of CT findings of patients with complicated pneumonia treated between January 2010 and December 2019. Fisher's exact test and ROC curves were used for statistical analysis.
Background And Aims: SARS-CoV-2 is a worldwide serious health problem. The aim of this study was to demonstrate the number of potentially infectious particles present during endoscopic procedures and find effective tools to eliminate the risks of SARS-CoV-2 infection while performing them.
Methods: An experimental model which focused on aerosol problematics was made in a specialized laboratory.
Conjugated Hyperbilirubinemia in Infants: Is There Still a Role for ERCP?
Can J Gastroenterol Hepatol
October 2021
Over a twenty-year period, we performed 255 ERCP procedures in infants aged up to 1 year. ERCP was indicated in cholestatic infants with suspicion of biliary obstruction. The most common diagnosis was biliary atresia (48%), choledochal cysts (13%), and choledocholithiasis (4%).
View Article and Find Full Text PDFPortal vein thrombosis (PVT) is a partial or complete thrombotic occlusion of the portal vein and is rare in noncirrhotic patients. 78 adult patients with noncirrhotic acute PVT without known malignity were evaluated. Patients with initial CRP level 61-149 mg/l were excluded.
View Article and Find Full Text PDFBackground: Endoscopic retrograde cholangiopancreatography (ERCP) is seldom used in children, and published series have limited numbers of pediatric patients. The aim of this retrospective observational study was to assess the efficacy and safety of pediatric ERCP in a large group of children.
Methods: Data were evaluated from 626 children with biliopancreatic disorders admitted to University Hospital Motol, Prague, between January 1999 and January 2018.
Article Synopsis
- The study assessed compliance to mesalazine treatment in ulcerative colitis patients, finding that 21.2% were noncompliant with their medication.
- Education level significantly affected compliance, with patients holding university degrees showing higher adherence than those with only secondary education, and individuals preferred taking mesalazine once daily to enhance consistency.
- Improving mesalazine adherence can be achieved by considering patient preferences in treatment, suggesting that tailoring therapy based on education and dosage forms may result in better outcomes in clinical practice.
Article Synopsis
- The study monitored the effectiveness of the infliximab biosimilar CT-P13 in treating patients with inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC), in the Czech Republic.
- Out of 52 patients treated, 50% of those with CD and 40.9% with UC achieved remission after 14 weeks, with significant improvements in disease activity indices and serum C-reactive protein levels.
- The study concluded that CT-P13 is effective in managing IBD, with a few reported adverse events, highlighting its potential as a treatment option.