The impact of food allergens on airway responsiveness in schoolchildren with asthma: A DBPCFC study.

Background And Objective: Despite the growing evidence of a possible link between asthma and food allergy (FA), so far, the involvement of food in inducing respiratory symptoms has not been fully evaluated. The objective of this study was to evaluate the impact of food allergens on respiratory symptoms and bronchial reactivity (BHR) in schoolchildren with asthma.

Methods: The initial study group consisted of 362 children with asthma.

Decreased FOXP3 mRNA expression in children with atopic asthma and IgE-mediated food allergy.

Background: The role of T regulatory lymphocytes has been investigated in various allergic diseases. However, the precise relation between the phenotype and severity of allergic diseases and the changes in FOXP3 mRNA expression are not fully understood.

Objective: To compare the expression of FOXP3 mRNA in children with asthma with and without concomitant food allergy (FA) with healthy children and children with only FA.

Prevalence and Clinical Impact of IgE-Mediated Food Allergy in School Children With Asthma: A Double-Blind Placebo-Controlled Food Challenge Study.

Purpose: Recent studies indirectly suggest a possible link between food allergy (FA) and asthma. Most of them have evaluated the occurrence of FA in asthmatic children, especially in the first year of life, using questionnaire-based studies or specific IgE (sIgE) assay. The aim of this study was to evaluate the prevalence and clinical impact of IgE-mediated FA in school children with asthma using a double-blind placebo-controlled food challenge (DBPCFC).

Immunogenicity and safety of a 13-valent pneumococcal conjugate vaccine administered to older infants and children naïve to pneumococcal vaccination.

Background: Streptococcus pneumoniae infections are a major cause of morbidity and mortality in children <5 years old worldwide. To increase serotype coverage globally, a 13-valent pneumococcal conjugate vaccine (PCV13) has been developed and approved in many countries worldwide.

Objective: Assess the safety and immunogenicity of PCV13 in healthy older infants and children naïve to previous pneumococcal vaccination.

[Nutritional guidelines for healthy children aged 1-3 years - Polish Expert Group statement. Part I- energy and nutritional components demand].

Updating of the nutritional guidelines for the Polish population requires updates of the nutritional norms for children. We present the Polish Expert Group statement (2012) on intake of selected nutrients (protein, lipids, carbohydrates, vitamin D and E) essential in nutrition of children aged 1-3 years. For this purpose the Expert Group reviewed available scientific data: the recent guidelines, nutritional norms and recommendations, systematic reviews and expert opinions as well as original publications, in relation to the specific requirements of the Polish population.

Influence of percutaneous endoscopic gastrostomy on gastro-oesophageal reflux evaluated by multiple intraluminal impedance in children with neurological impairment.

Aim: The aim of the study was to estimate the influence of percutaneous endoscopic gastrostomy (PEG) placement on gastro-oesophageal reflux (GOR) by using multiple intraluminal impedance (MII/pH) measurements in children with neurological impairments.

Method: Fifteen children with neurological impairments (cerebral palsy, n=10; cerebroidolipofuscinosis, n=2; Aicardi syndrome, n=1; and secondary encephalopathy, n=2) were investigated (interquartile range [IQR] 6y 4mo-14y 8mo; median age 10y 2mo; eight male, seven female). Individuals with nutritional disorders that could not be corrected by physiological means or with swallowing disorders that either caused chronic respiratory symptoms or prevented food intake were included in the study.

[Rome III classification of functional gastrointestinal disorders in children with chronic abdominal pain].

Background: The updated Rome III Classification of paediatric functional gastrointestinal disorders (FGIDs) associated with abdominal pain comprises: functional dyspepsia (FD), irritable bowel syndrome (IBS), abdominal migraine, functional abdominal pain (FAP), functional abdominal pain syndrome (FAPS).

The Aim Of This Study: To assess the value of the Rome criteria in identifying FGIDs in children with chronic abdominal pain.

Material And Methods: The study group consisted of 439 consecutive paediatric patients (192 boys and 247 girls) aged 4-18 years (mean age was 11.

FOXP3, IL-10, and TGF-β genes expression in children with IgE-dependent food allergy.

Background: Regulatory T cells (Tregs) have an essential role in tolerance and immune regulation. However, few and controversial data have been published to date on the role and number of these cells in food allergic children. The forkhead/winged-helix transcription factor box protein 3 (FOXP3) is considered the most reliable marker for Tregs.

Bronchial reactivity in schoolchildren allergic to food.

Background: Food allergy (FA) is associated with an increased risk of asthma.

Objective: To evaluate whether bronchial hyperreactivity (BHR) occurs in children with FA depending on the presence of respiratory symptoms.

Methods: Fifty-four children with FA and 62 without FA were studied for BHR, defined as a provocation concentration of methacholine that caused a decrease in forced expiratory volume in 1 second of 20% (PC20).

Evaluation of receptor expression on immune system cells in the peripheral blood of asthmatic children undergoing food challenges.

Background: The role of food allergens in the induction of allergic reactions in the airways is not completely understood. The aim of the present study was to evaluate fluorocytometric assays of the peripheral blood during food challenge tests in children with asthma and food allergy.

Patients And Methods: 22 children with asthma and concomitant food allergy and 18 children with asthma without food allergy participated in the study.

[Paediatric Expert Group on the Immunization Programme. Activities focusing on effective immunization in Poland].

The Paediatric Expert Group on the Immunization Programme was established in January 2007. It is an independent advisory body to the Minister of Health. The Expert Group consists of paediatricians from various sub-specialities.

Cytokine profile in children with asthma undergoing food challenges.

Background: The influence of food allergens on the profile of inflammatory markers in children with asthma has not been investigated. To ascertain the influence of food allergens on the intensity of the inflammatory process, a cytokine profile was determined before and after a food challenge test in the peripheral blood of children with asthma and coexistent food allergy.

Material And Methods: We studied 22 children with asthma and immunoglobulin (Ig) E-dependent food allergy.

[Evaluation of bronchial hyperreactivity in children with asthma undergoing food challenges].

Unlabelled: It has been shown that food allergy does not always manifest within the respiratory tract in such as obvious way as: dyspnea, cough or wheezing. The aim of the study was to evaluate the influence of food allergens on bronchial reactivity in children with asthma challenged with food.

Materials And Methods: A total of 304 patients (age range 5.

[Food challenges in children with asthma].

Unlabelled: Food-induced symptoms are often reported and increasing problem, also for children with asthma. Evaluation of the possibility of concomitant food allergy in patients with asthma and implementation of adequate therapy can improve quality of life in these patients. The aim of the study was to evaluate the prevalence of IgE food allergy and the influence of food allergen ingestion on the course of asthma in children allergic to inhalant allergens during food challenges.

[Role of IgE-dependent reactions in atopic dermatitis].

Unlabelled: Atopic dermatitis is a disease of multifactorial pathogenesis.

The Aim: of the study was to establish the most common allergens responsible for development of atopic symptoms in children with atopic dermatitis.

Material And Method: the study complied 36 children aged 4 months - 3 years treated in the Department of Children Allergology, Gastroenterology and Nutrition because of atopic dermatitis.

[Tolerance of enteral nutrition in children with acute pancreatitis].

Aim: evaluation of tolerance and efficacy of enteral nutrition inpatients with acute pancreatitis hospitalised in 2005-2006 in Department of Paediatric Allergology, Gastroenterology and Nutrition, Medical University of Lodz.

Material And Methods: analysis involved the course of enteral nutrition in 15 children hospitalised in 2005-2006 (aged 11.24+/-3.

[Helicobacter pylori infection and its metabolic consequences in children and adolescents with type 1 diabetes mellitus].

Unlabelled: Helicobacter pylori infection (Hp) is the cause of chronic gastritis and duodenitis, ulcer disease, and functional gastrointestinal motor disorders. Its prevalence among Polish children with type 1 diabetes mellitus has been estimated at 25%. There is limited data regarding the influence of Helicobacter pylori infection on clinical course of diabetes, with controversial results.

Electrogastrography in children and adolescents with type 1 diabetes: weak correlation with metabolic control parameters.

Aim: To evaluate gastric myoelectrical activity with respect to duration and metabolic control of type 1 diabetes mellitus (T1DM).

Methods: 172 children and adolescents with T1DM (mean 14.4+/-3.

Candida albicans Berthout, 1923: hydrolases activity and own method of digestive tract strains biotyping.

112 strains of Candida albicans were isolated from oral cavity and ontocenoses of the upper digestive tract (endoscopy) of children (age: 5-17) with gastrointestinal disorders. Axenic strains were differentiated with API 20C AUX and API ZYM tests (bioMérieux). Then enzymograms and biotypes were determined for all the strains based on the activity of 19 hydrolases.

[Analyse of fungi prevalence and their species in the digestive tract of adult persons and children].

Analyse of fungi prevalence and their species in the digestive tract of adult persons and children. 1081 faecal sample were examined, 723 from adult persons and 358 from children. Fungal strains were recovered in 67.

[The sensitivity to ketoconazole of Candida strains isolated from the digestive tract ontocenoses in children].

The study included 52 children. During endoscopy the contents of oesophagus, stomach and duodenum were collected with catheters, and additionally washings from the oral cavity and anal swabs or samples of faeces. Materials were inoculated on Sabouraud's media.

[Fungal invasions in the digestive tract in children].

The aim of presented study were fungal invasions of the oral cavity and gastrointestinal (GI) tract in children suspected of the inflammation of gastric and duodenal mucosa and of absorption disturbance. The fungal strains (125) were identified using API 20C and API 20C AUX (bio Me'rieux); they were as follows: Candida albicans, C. famata, C.

[Biochemical characteristics of fungi isolated from ontocenoses of digestive tract in children].

Fermentation of carbohydrates and assimilation of carbon compounds were evaluated. The utilization of 18 specific carbon compounds was estimated in the investigation of each strains for differentiation of the species. From among 125 strains of fungi the following were found: Candida albicans (112 strain), C.

Prevalence of EGG derangement in newly diagnosed type 1 diabetes in childhood.

Objective: To evaluate gastric myoelectrical activity in children with newly diagnosed type 1 diabetes melliltus (T1DM) in relation to blood glucose control and visceral neuropathy.

Methods: Percutaneous electrogastrograpy (EGG) was performed on 42 children (20 F; mean age 12.9 +/- 3.