Unleashing the potential of natural protein based nanoparticles for the delivery of therapeutic nucleic Acid: A comprehensive review.

Nucleic acid-based therapeutics represent a revolutionary approach in treating genetic disorders, offering unprecedented potential for addressing pathologies at their molecular level. However, effective cellular delivery remains a critical challenge hindering their clinical implementation. While existing delivery systems, including viral vectors and lipid nanoparticles, have shown utility, they face limitations in immunogenicity, cargo capacity, and manufacturing complexity.

A Preliminary Study on Kinetic Analysis of Ground Reaction Force and Impulse During Gait in Patients With Total Hip Replacement and Implication for Rehabilitation.

Background: There is little research done on ground reaction forces (GRF) in terms of 3D impulses after total hip replacement (THR). This study aimed to investigate the GRFs and 3D impulses in four sub-phases of stance during gait in the patients undergoing THR.

Methods: A total of 10 pain-free THR patients and 10 healthy people were recruited.

Mechanical energy fluctuation in lower limbs during walking in participants with and without total hip replacement.

Mechanical energy fluctuation of the segments of lower limbs during walking has not been fully investigated. It was hypothesized that the segments may work as a pendulum, i.e.

A Review of Passive Micromixers with a Comparative Analysis.

A wide range of existing passive micromixers are reviewed, and quantitative analyses of ten typical passive micromixers were performed to compare their mixing indices, pressure drops, and mixing costs under the same axial length and flow conditions across a wide Reynolds number range of 0.01-120. The tested micromixers were selected from five types of micromixer designs.

Asymmetrical Split-and-Recombine Micromixer with Baffles.

The present work proposes a planar micromixer design comprising hybrid mixing modules of split-and-recombine units and curved channels with radial baffles. The mixing performance was evaluated numerically by solving the continuity and momentum equations along with the advection-diffusion equation in a Reynolds number range of 0.1-80.

Single and Multi-Objective Optimization of a Three-Dimensional Unbalanced Split-and-Recombine Micromixer.

The three-dimensional geometry of a micromixer with an asymmetrical split-and-recombine mechanism was optimized to enhance the fluid-mixing capability at a Reynolds number of 20. Single and multi-objective optimizations were carried out by using particle swarm optimization and a genetic algorithm on a modeled surrogate surface. Surrogate modeling was performed using the computational results for the mixing.

Multi-Objective Optimizations of a Serpentine Micromixer with Crossing Channels at Low and High Reynolds Numbers.

In order to maximize the mixing performance of a micromixer with an integrated three-dimensional serpentine and split-and-recombination configuration, multi-objective optimizations were performed at two different Reynolds numbers, 1 and 120, based on numerical simulation. Numerical analyses of fluid flow and mixing in the micromixer were performed using three-dimensional Navier-Stokes equations and convection-diffusion equation. Three dimensionless design variables that were related to the geometry of the micromixer were selected as design variables for optimization.