Toward Planetary Health Ethics? Refiguring Bios in Bioethics.

In responding to perceived crises-such as the COVID-19 pandemic-in routinized ways, contemporary bioethics can make us prisoners of the proximate. Rather, we need bioethics to recognize and engage with complex configurations of global ecosystem degradation and collapse, thereby showing us paths toward co-inhabiting the planet securely and sustainably. Such a planetary health ethics might draw rewardingly on Indigenous knowledge practices or Indigenous philosophical ecologies.

Immunities of the Herd in Peace, War, and COVID-19.

Intermittently, the concept of herd immunity has been a potent, if sometimes ambiguous and controversial, means of framing the global response to the COVID-19 pandemic and envisaging its end. Realizing the full meaning of human herd immunity requires further attention to its connections after World War I with British social theory. Distracted by "obvious" yet unsubstantiated correspondences with veterinary research, historians of the concept have not engaged with the more proximate influence of discussions of social psychology and group dynamics on postwar epidemiology.

History and philosophy of science takes form.

During the past hundred years the strength of the amalgam of history and philosophy of science (HPS) has waxed and waned, while assuming multiple forms and acquiring different imprints. In the 1940s and 1950s, philosopher Gerd Buchdahl and colleagues in Melbourne, Australia, assembled a methodologically powerful version of HPS, drawing on their readings, with general historians, of the philosophical works of R.G.

Cycles and circulation: a theme in the history of biology and medicine.

We invite systematic consideration of the metaphors of cycles and circulation as a long-term theme in the history of the life and environmental sciences and medicine. Ubiquitous in ancient religious and philosophical traditions, especially in representing the seasons and the motions of celestial bodies, circles once symbolized perfection. Over the centuries cyclic images in western medicine, natural philosophy, natural history and eventually biology gained independence from cosmology and theology and came to depend less on strictly circular forms.

The model crisis, or how to have critical promiscuity in the time of Covid-19.

During the past forty years, statistical modelling and simulation have come to frame perceptions of epidemic disease and to determine public health interventions that might limit or suppress the transmission of the causative agent. The influence of such formulaic disease modelling has pervaded public health policy and practice during the Covid-19 pandemic. The critical vocabulary of epidemiology, and now popular debate, thus includes R, the basic reproduction number of the virus, 'flattening the curve', and epidemic 'waves'.

The Whiteness of Bioethics.

A discussion of whiteness as an "ethos" or "relational category" in bioethics, drawing on examples from medical and historical research.

Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human.

A physiologically based pharmacokinetic (PBPK) model for di-isononyl phthalate (DiNP) was developed by adapting the existing models for di(2-ethylhexyl) phthalate (DEHP) and di-butylphthalate (DBP). Both pregnant rat and human time-course plasma and urine data were used to address the hydrolysis of DiNP in intestinal tract, plasma, and liver as well as hepatic oxidative metabolism and conjugation of the monoester and primary oxidative metabolites. Data in both rats and humans were available to inform the uptake and disposition of mono-isononyl phthalate (MiNP) as well as the three primary oxidative metabolites including hydroxy (7-OH)-, oxo (7-OXO)-, and carboxy (7-COX)-monoisononyl phthalate in plasma and urine.

Excretion of Di-2-ethylhexyl phthalate (DEHP) metabolites in urine is related to body mass index because of higher energy intake in the overweight and obese.

A higher body mass index (BMI) has been positively associated with the rate of excretion of di-2-ethylhexyl phthalate (DEHP) metabolites in urine in data from the National Health and Nutrition Examination Survey (NHANES), suggesting an association between DEHP exposure and BMI. The association, however, may be due to the association between body mass maintenance and higher energy intake, with higher energy intake being accompanied by a higher intake of DEHP. To examine this hypothesis, we ran a Monte Carlo simulation with a DEHP physiologically-based pharmacokinetic (PBPK) model for adult humans.

Nowhere to run, rabbit: the cold-war calculus of disease ecology.

During the cold war, Frank Fenner (protégé of Macfarlane Burnet and René Dubos) and Francis Ratcliffe (associate of A. J. Nicholson and student of Charles Elton) studied mathematically the coevolution of host resistance and parasite virulence when myxomatosis was unleashed on Australia's rabbit population.

Applying a southern solvent: an interview with Warwick Anderson.

An interview by the editor and a member of the scientific board of História, Ciências, Saúde - Manguinhos with Warwick Anderson, a leading historian of science and race from Australia. He talks about his training, positions he held at US universities, his publications, and his research at the University of Sydney. He discusses his current concern with the circulation of racial knowledge and biological materials as well as with the construction of networks of racial studies in the global south during the twentieth century.

Postcolonial Ecologies of Parasite and Host: Making Parasitism Cosmopolitan.

The interest of F. Macfarlane Burnet in host-parasite interactions grew through the 1920s and 1930s, culminating in his book, Biological Aspects of Infectious Disease (1940), often regarded as the founding text of disease ecology. Our knowledge of the influences on Burnet's ecological thinking is still incomplete.

'The Right Time and the Right Place': An Interview with Jacques Miller.

Professor Jacques F.P. Miller spoke about his career in immunology with Warwick Anderson on 3 February 2014.

Global implementation of genomic medicine: We are not alone.

Around the world, innovative genomic-medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens. Such individual efforts might benefit from the sharing of approaches and lessons learned in other locales. The U.

Wandering anatomists and itinerant anthropologists: the antipodean sciences of race in Britain between the wars.

While the British Empire conventionally is recognized as a source of research subjects and objects in anthropology, and a site where anthropological expertise might inform public administration, the settler-colonial affiliations and experiences of many leading physical anthropologists could also directly shape theories of human variation, both physical and cultural. Antipodean anthropologists like Grafton Elliot Smith were pre-adapted to diffusionist models that explained cultural achievement in terms of the migration, contact and mixing of peoples. Trained in comparative methods, these fractious cosmopolitans also favoured a dynamic human biology, often emphasizing the heterogeneity and environmental plasticity of body form and function, and viewing fixed, static racial typologies and hierarchies sceptically.

Getting ahead of one's self? The common culture of immunology and philosophy.

During the past thirty years, immunological metaphors, motifs, and models have come to shape much social theory and philosophy. Immunology, so it seems, often has served to naturalize claims about self, identity, and sovereignty--perhaps most prominently in Jacques Derrida's later studies. Yet the immunological science that functions as "nature" in these social and philosophical arguments is derived from interwar and Cold War social theory and philosophy.

Racial conceptions in the global south.

What happens to twentieth-century race science when we relocate it to the Global South? North Atlantic debates have dominated the conceptual history of race. Yet there is suggestive evidence of a "southern" or antipodean racial distinctiveness. We can find across the Southern Hemisphere greater interest in racial plasticity, environmental adaptation, mixing or miscegenation, and blurring of racial boundaries; endorsement of biological absorption of indigenous populations; and consent to the formation of new or blended races.

A history of health and medical research in Australia.

Health and medical research has played an important role in improving the life of Australians since before the 20th century, with many Australian researchers contributing to important advances both locally and internationally. The establishment of the National Health and Medical Research Council (NHMRC) to support research and to work to achieve the benefits of research for the community was significant. The NHMRC has also provided guidance in research and health ethics.

Formation of monochloropropane-1,2-diol and its esters in biscuits during baking.

The formation of free monochloropropane-1,2-diol (3-MCPD and 2-MCPD) and its esters (bound-MCPD) was investigated in biscuits baked with various time and temperature combinations. The effect of salt as a source of chloride on the formation of these processing contaminants was also determined. Kinetic examination of the data indicated that an increasing baking temperature led to an increase in the reaction rate constants for 3-MCPD, 2-MCPD, and bound-MCPD.