Effects of a meal replacement system alone or in combination with phentermine on weight loss and food cravings.

Objective: To examine the effects of phentermine combined with a meal replacement program on weight loss and food cravings and to investigate the relationship between food cravings and weight loss.

Methods: In a 12-week randomized, double-blind, placebo-controlled clinical trial, 77 adults with obesity received either phentermine or placebo. All participants were provided Medifast meal replacements, were instructed to follow the Take Shape for Life Optimal Weight 5&1 Plan for weight loss, and received lifestyle coaching in the Habits of Health program.

Interaction between infectious diseases and personality traits: ACP1*C as a potential mediator.

In geographical regions characterized by high pathogen prevalence, it has been shown that human populations tend to be characterized by lower levels of extraversion (E) and openness to experience (OtE). According to the "behavioral immune system" hypothesis, the reduction of extraversion and openness levels represents a behavioral defense against infections. Like the 'classical' immune system, the "behavioral immune system" could also be shaped by its underlying genetic background.

Phenylethanolamine N-methyltransferase G-148A genetic variant and weight loss in obese women.

Objective: To understand the impact of the phenylethanolamine N-methyltransferase (PNMT) G-148A gene and nutritional variables on weight loss in obese women.

Research Methods And Procedures: One hundred forty-nine women, ages 45 to 65 with a body mass index of >30 kg/m(2), participated in a 6-month, open-label intervention that included sibutramine (15 mg/d) and a monthly health-education class. Anthropometric measurements, vital signs, food frequency, exercise log, medication compliance, and psychological and sociological questionnaires were completed each month.