Publications by authors named "Warren O Wong"
Article Synopsis
- Sialic acid (Neu5Ac) is added to glycoconjugates by sialyltransferases (STs) using a specific donor molecule, CMP-β-d-Neu5Ac, while the only existing ST inhibitors are based on a modified form of sialic acid known as 3FNeu5Ac.
- Researchers aimed to create a controlled process for generating 3FNeu5Ac using the enzyme sialic acid aldolase, but faced challenges with properly positioning the fluorine atom in the molecule.
- They discovered a method using CMP-sialic acid synthetase that successfully produced CMP-3FNeu5Ac, leading to a novel compound (3FNeu5Ac-2
The design of small molecules with unique geometric profiles or molecular connectivity represents an intriguing yet neglected challenge in modern organic synthesis. This challenge is compounded when emphasis is placed on the preparation of new chemotypes that have distinct and practical functions. To expand the structural diversity of boron-containing heterocycles, we report herein the preparation of novel monocyclic hemiboronic acids, diazaborines.
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