In Vitro and In Vivo Drug-Response Profiling Using Patient-Derived High-Grade Glioma.

Background: Genomic profiling cannot solely predict the complexity of how tumor cells behave in their in vivo microenvironment and their susceptibility to therapies. The aim of the study was to establish a functional drug prediction model utilizing patient-derived GBM tumor samples for in vitro testing of drug efficacy followed by in vivo validation to overcome the disadvantages of a strict pharmacogenomics approach.

Methods: High-throughput in vitro pharmacologic testing of patient-derived GBM tumors cultured as 3D organoids offered a cost-effective, clinically and phenotypically relevant model, inclusive of tumor plasticity and stroma.

The effects of strength training upon front foot contact ground reaction forces and ball release speed among high-level cricket pace bowlers.

The effects of an eight-week off-season strength training program upon lower-body strength, power, eccentric capacity, front foot contact (FFC) kinetics, and ball release speed (BRS) in pace bowlers were investigated. Ten elite-academy pace bowlers completed the intervention, and pre- and post-testing. Pre- and post-testing included: double (DLDL) and single leg (SLDL) drop landings; isometric mid-thigh pull (IMTP); countermovement jump; and pace bowling performance (two-over bowling spell measuring BRS and FFC kinetics).

Does Delivery Length Impact Measures of Whole-Body Biomechanical Load During Pace Bowling?

Purpose: To investigate whether changes in delivery length (ie, short, good, and full) lead to alterations in whole-body biomechanical loading as determined by ground reaction force during front-foot contact of the delivery stride for pace bowlers. Current load-monitoring practices of pace bowling in cricket assume equivocal biomechanical loading as only the total number of deliveries are monitored irrespective of delivery length.

Methods: A total of 16 male pace bowlers completed a 2-over spell at maximum intensity while targeting different delivery lengths (short, 7-10 m; good, 4-7 m; and full, 0-4 m from the batter's stumps).

The Effects of an Eight over Cricket Bowling Spell upon Pace Bowling Biomechanics and Performance within Different Delivery Lengths.

Pace bowlers must often perform extended bowling spells with maximal ball release speed (BRS) while targeting different delivery lengths when playing a multi-day match. This study investigated the effect of an eight over spell upon pace bowling biomechanics and performance at different delivery lengths. Nine male bowlers (age = 18.

The relationship between inertial measurement unit-derived 'force signatures' and ground reaction forces during cricket pace bowling.

This study assessed the reliability and validity of segment measured accelerations in comparison to front foot contact (FFC) ground reaction force (GRF) during the delivery stride for cricket pace bowlers. Eleven recreational bowlers completed a 30-delivery bowling spell. Trunk- and tibia-mounted inertial measurement units (IMUs) were used to measure accelerations, converted to force, for comparisons to force plate GRF discrete measures.

Rapid detection of structural variation in a human genome using nanochannel-based genome mapping technology.

Background: Structural variants (SVs) are less common than single nucleotide polymorphisms and indels in the population, but collectively account for a significant fraction of genetic polymorphism and diseases. Base pair differences arising from SVs are on a much higher order (>100 fold) than point mutations; however, none of the current detection methods are comprehensive, and currently available methodologies are incapable of providing sufficient resolution and unambiguous information across complex regions in the human genome. To address these challenges, we applied a high-throughput, cost-effective genome mapping technology to comprehensively discover genome-wide SVs and characterize complex regions of the YH genome using long single molecules (>150 kb) in a global fashion.

Can a Specific Neck Strengthening Program Decrease Cervical Spine Injuries in a Men's Professional Rugby Union Team? A Retrospective Analysis.

Cervical spine injuries in Rugby Union are a concerning issue at all levels of the game. The primary aim of this retrospective analysis conducted in a professional Rugby Union squad was to determine whether a 26-week isometric neck strengthening intervention program (13-week strengthening phase and 13-week maintenance phase) was effective in reducing the number and severity of cervical spine injuries. The secondary aim was to determine whether at week five, where the program had been the similar for all players, there was increased isometric neck strength.

Does performance of hang power clean differentiate performance of jumping, sprinting, and changing of direction?

The primary purpose of this study was to investigate whether the athlete who has high performance in hang power clean, a common weightlifting exercise, has high performances in sprinting, jumping, and changing of direction (COD). As the secondary purpose, relationships between hang power clean performance, maximum strength, power and performance of jumping, sprinting, and COD also were investigated. Twenty-nine semiprofessional Australian Rules football players (age, height, and body mass [mean +/- SD]: 21.

Comparison of weighted jump squat training with and without eccentric braking.

The purpose of this study was to investigate the effect of weighted jump squat training with and without eccentric braking. Twenty male subjects were divided into two groups (n = 10 per group), Non-Braking Group and Braking Group. The subjects were physically active, but not highly trained.

Comparison of four different methods to measure power output during the hang power clean and the weighted jump squat.

Measurement of power output during resistance training is becoming ubiquitous in strength and conditioning programs, but there is great variation in the methods used. The main purposes of this study were to compare the power output values obtained from 4 different methods and to examine the relationships between these values. Male semiprofessional Australian rules football players (n = 30) performed hang power clean and weighted jump squat while ground reaction force (GRF)-time data and barbell displacement-time data were sampled simultaneously using a force platform and a linear position transducer attached to the barbell.