Publications by authors named "Warner Hoornenborg"
Article Synopsis
- The study investigated how different diets (low-fat vs. high-fat/sucrose) affected weight loss after Roux-en-Y gastric bypass (RYGB) surgery in rats.
- Rats fed a high-fat/sucrose diet lost more weight post-surgery compared to those on a low-fat diet, primarily due to lower energy intake and initial body weight differences.
- Interestingly, continuing the high-fat/sucrose diet did not hinder recovery from surgery, even though low-fat dieting led to signs of malaise following RYGB.
Intestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via its modulation of L-type voltage-gated calcium channels located on the intestinal smooth muscle cells. Dysregulation of L-type voltage-gated calcium channels is associated with various gastrointestinal motility disorders, including constipation, making L-type voltage-gated calcium channels an important target for drug development.
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