Publications by authors named "Wareeporn Disphanurat"

Article Synopsis
  • The study investigates the genetic factors that may predict cutaneous adverse drug reactions (cADRs) to allopurinol in Thai patients, alongside the known HLA-B*58:01 allele.
  • Researchers conducted a case-control study with 57 patients who experienced cADRs and 101 controls who tolerated the medication, analyzing specific genetic markers on chromosome 6p21.
  • Four single nucleotide polymorphisms (SNPs) were identified as significant predictors for cADRs, showing a strong correlation, and the findings suggest these SNPs could serve as new biomarkers for risk assessment in allopurinol therapy.
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  • Diagnosing drug-induced nonimmediate allergies is difficult, leading to potential misclassifications, so the study aimed to assess how well IFN-γ ELISpot and clinical factors can predict these reactions using machine learning.
  • The research included 393 patients and used positive patch tests or drug provocation tests (DPT) to identify hypersensitivity, leading to models like random forest (RF) and logistic regression (LR) that outperformed the IFN-γ ELISpot alone.
  • Results showed 94.8% specificity but lower sensitivity for IFN-γ ELISpot; RF and LR models had adjustable cutoff values to balance sensitivity and specificity, while the IFN-γ ELISpot
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Objective: A fractional 1064-nm picosecond laser is an efficient and safe treatment for atrophic acne scars. However, evidence of using a picosecond laser for atrophic posttraumatic and surgical scar therapy is lacking. This study aimed to evaluate the efficacy and safety of using a 1064-nm picosecond laser with a microlens array (MLA) for the treatment of atrophic posttraumatic and surgical scars.

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The treatment of hypertrophic scars (HTSs) and keloids remains a challenge. Intralesional triamcinolone acetonide (TAC) is the mainstay treatment for these conditions. Despite its efficacy, TAC has several adverse side effects, including telangiectasias, skin atrophy, pigmentary changes, and skin necrosis.

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Background: Botulinum toxin A benefits postsurgical scar prevention by reducing wound edge tension and inhibiting in vitro scar tissue fibrosis.

Objective: To investigate the efficacy of botulinum toxin Type A (BTX) in improving inframammary scar appearance after primary breast augmentation.

Materials And Methods: A prospective, double-blinded, randomized controlled trial was performed with 27 participants receiving primary augmentation mammoplasty with inframammary incisions.

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Article Synopsis
  • The study aimed to use enzyme-linked immunospot assays (ELISpot) to identify specific immune cells that release mediators in response to certain drugs associated with severe skin reactions (SCARs).
  • Researchers assessed the reactions of peripheral blood cells from SCAR patients to potential culprit drugs, measuring the levels of interleukin-22, interferon-gamma, and granzyme-B.
  • Results indicated that a combined approach measuring these mediators improved detection sensitivity of the causing drugs, especially for AGEP, and suggested that using alpha-galactosylceramide could further enhance responses in detecting drugs involved in SCARs.
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Background: Melasma has a complex pathogenesis, and various aggravating factors contribute to its recalcitrance to treatments. A combination of isobutylamido thiazolyl resorcinol (ITR) and hyaluronic acid (HA) could increase melasma treatment efficacy.

Aims: To compare the efficacy and safety of 0.

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Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has received increasing interest among plastic surgeons as a long-term complication of breast augmentation. Although the prognosis is usually good, mortality is a possible outcome. Most of the cases reported in the past two decades have been from the United States, Europe, and Australia, whereas cases of BIA-ALCL in Asia remain rare.

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Article Synopsis
  • A case-control study was conducted to examine the connection between genetic variants in HLA and CYP2C9 and severe cutaneous adverse reactions (SCARs) induced by co-trimoxazole (CTX) in Thai patients.
  • The study included 30 patients with CTX-induced SCARs (18 with SJS/TEN and 12 with DRESS) and compared them to 91 CTX-tolerant controls and 150 individuals from the general population.
  • Results revealed specific genetic associations: HLA-B*15:02 and HLA-C*08:01 were linked to SJS/TEN, while HLA-B*13:01 was associated with DRESS, particularly in HIV-infected patients.
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: A knee arthroplasty results in a long vertical scar on the knee and has a high risk for the development of hypertrophic or keloid scarring. The purpose of this study is to determine the efficacy and safety of the use of a 595 nm pulsed-dye-laser (PDL) for this type of scar. : This randomized, controlled study was conducted in 40 patients (41 scars) with postoperative knee arthroplasties.

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  • A study was conducted to assess the effectiveness of oral vitamin D supplementation on psoriasis treatment in patients, as previous trials have shown inconclusive results, especially in Asia.
  • Patients were randomly assigned to receive either 60,000 IU of vitamin D2 or a placebo every two weeks for six months, with their psoriasis severity measured using the Psoriasis Area and Severity Index (PASI).
  • Results indicated that the vitamin D2 group experienced a significant improvement in PASI scores compared to the placebo, with higher serum vitamin D levels, no major adverse events reported, and an overall positive outcome from the supplementation.
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Objectives: Striae distensae are linear atrophic dermal scars. Despite several currently available therapeutic modalities, no consistently effective therapies have been established. This study aimed to evaluate and compare the efficacy of topical recombinant human epidermal growth factor (rhEGF) and ablative fractional carbon dioxide (CO ) laser (AFXL) versus ablative fractional CO laser and topical Aloe vera gel in treating striae alba.

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  • - The study focused on translating the Drug Hypersensitivity Quality of Life (DrHy-Q) Questionnaire from Italian to Thai while assessing its validity and reliability among 306 Thai patients with drug hypersensitivity.
  • - Results indicated that the Thai DrHy-Q demonstrated strong reliability (with a Cronbach's α of 0.94 and an ICC of 0.8) and a solid unidimensional structure, confirming its effectiveness through various validity tests.
  • - The Thai DrHy-Q could effectively distinguish between serious and non-serious drug allergic reactions, showcasing its utility in evaluating patient quality of life in this context.
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Article Synopsis
  • The study investigated the effectiveness of HLA-B allele prescreening and drug-specific IFN-γ-releasing cells in preventing and identifying the drugs responsible for severe cutaneous adverse reactions (SCARs) in patients.
  • It involved 160 patients from Thai universities, revealing that common culprits included anticonvulsants, allopurinol, and beta-lactams, with prescreening having the potential to prevent 21.2% of cases.
  • The findings indicated that drug-specific IFN-γ-releasing cells were detectable in about 45.7% of SCAR patients, suggesting a need for improved strategies to better prevent and identify culprit drugs.
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Background: Noninvasive fat removal is preferred because of decreased downtime and lower perceived risk. It is important to seek new noninvasive fat removal treatments that are both safe and efficacious.

Objective: To assess the extent to which carboxytherapy, which is the insufflation of carbon dioxide gas into subcutaneous fat, results in reduction of fat volume.

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Importance: Common noninvasive to minimally invasive cosmetic dermatologic procedures are widely believed to be safe given the low incidence of reported adverse events, but reliable incidence data regarding adverse event rates are unavailable to date.

Objective: To assess the incidence of adverse events associated with noninvasive to minimally invasive cosmetic dermatologic procedures, including those involving laser and energy devices, as well as injectable neurotoxins and fillers.

Design, Setting, And Participants: A multicenter prospective cohort study (March 28, 2011, to December 30, 2011) of procedures performed using laser and energy devices, as well as injectable neurotoxins and soft-tissue augmentation materials, among 8 geographically dispersed US private and institutional dermatology outpatient clinical practices focused on cosmetic dermatology, with a total of 23 dermatologists.

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Importance: Keratosis pilaris (KP) is a common skin disorder of follicular prominence and erythema that typically affects the proximal extremities, can be disfiguring, and is often resistant to treatment. Shorter-wavelength vascular lasers have been used to reduce the associated erythema but not the textural irregularity.

Objective: To determine whether the longer-wavelength 810-nm diode laser may be effective for treatment of KP, particularly the associated skin roughness/bumpiness and textural irregularity.

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Importance: Neocollagenesis can be achieved using a dermal rolling needle device, thereby reducing the appearance of acne scars.

Objective: To determine the efficacy of a needling device for treatment of acne scars.

Design, Setting, And Participants: We performed a single-center, rater-blinded, balanced (1:1), split-face, placebo-controlled, parallel-group randomized clinical trial at an urban academic institution.

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Background: Pain is expected during noninvasive skin tightening and can be anxiety provoking, especially for those who have not had prior treatments.

Objective: To compare pain reported by patients naïve to nonablative skin tightening energy devices with those who were not naive.

Methods And Materials: The non-naïve group at least three nonablative laser procedures or one nonablative skin tightening procedure, and the naïve group no previous treatments.

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Importance: Detailed information regarding perioperative risk and adverse events associated with Mohs micrographic surgery (MMS) can guide clinical management. Much of the data regarding complications of MMS are anecdotal or report findings from single centers or single events.

Objectives: To quantify adverse events associated with MMS and detect differences relevant to safety.

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Background: Botulinum toxin injections and suction-curettage have been separately shown to be effective in treating axillary hyperhidrosis but have not been compared in the same patients.

Objective: We sought to compare effectiveness of suction-curettage versus neurotoxin for the treatment of axillary hyperhidrosis.

Methods: Each of 20 patients was randomized to receive toxin injections to one axilla and suction-curettage to the contralateral axilla.

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Many patients with eczematous dermatitis need continued care in case of a recurrent or persistent skin condition and potential adverse effect of medications. Allergic contact dermatitis should be considered in the differential diagnosis of eczematous dermatitis especially in a patient whose dermatitis is persistent despite appropriate therapies. Patch testing is an essential investigation in patients with persistent eczematous eruption when contact allergy cannot be ruled out.

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