An Additive-Fabricated Biphasic Scaffold for Procedurally Promoting Bone Regeneration via Antioxidant and Osteogenesis.

The repair process of bone tissue includes the early inflammatory response period and the late tissue repair period. It has been widely approved to be beneficial to the repair of bone injury by procedurally inhibiting the inflammatory response in the early stage and promoting bone regeneration in the late stage. In this study, the nano-hydroxyapatite/Poly(glycolide-co-caprolactone) (n-HA/PGCL) scaffold loaded with icariin was fabricated by fused deposition modeling technique, and the quercetin-loaded GelMA was further filled into the scaffold pores via light-curing methods to form a biphasic scaffold loaded with dual molecules (PHI + GQ scaffold).

Enhancing the Flotation Separation of Galena and Pyrite in the Presence of Seawater.

The effect of seawater on the flotation of sulfide minerals is a hot research topic at the present. Using seawater instead of fresh water to separate lead-sulfur can save fresh water resources and reduce lime consumption, which has broad prospects in terms of economic and environmental protection. Many studies have shown that divalent calcium and magnesium ions in seawater are hydrolyzed to form hydroxyl complexes under alkaline pH values, which affects the flotation separation of sulfide ore.

Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck.

Objective: Primary extranodal non-Hodgkin's lymphoma (PE-NHL) of the head and neck is the second common site of extranodal lymphoma, accounting for approximately one-third of all extranodal non-Hodgkin's lymphoma (E-NHL). However, in recent years, large-scale PE-NHL case studies in China and worldwide are rare and not comprehensive enough. This work analyzed the clinical manifestations, pathological features, immunophenotypes and diagnosis of PE-NHL, as well as the factors affecting the treatment and prognosis.

[Diffuse large B-cell lymphoma of thyroid invading the superior mediastinum with hashimoto's thyroiditis: a case report and literature review].

This article reports a case of primary thyroid diffuse large B-cell lymphoma involving the superior mediastinum with Hashimoto's thyroiditis admitted to the Department of Otolaryngology and Head and Neck Surgery, First Hospital of Jilin University. This patient underwent right thyroid lobectomy and was transferred to the Department of Hematology of the Oncology Center for 6 courses of chemotherapy with R-CHOP protocol. The postoperative recovery was good, and the patient was regularly followed up for 12 months after the operation.

Dual growth factor-modified microspheres nesting human-derived umbilical cord mesenchymal stem cells for bone regeneration.

Background: Modular tissue engineering (MTE) is a novel "bottom-up" approach that aims to mimic complex tissue microstructural features. The constructed micromodules are assembled into engineered biological tissues with repetitive functional microunits and form cellular networks. This is emerging as a promising strategy for reconstruction of biological tissue.

Droplet Characteristics at the Maximum Adhesion on Curved Surfaces.

For applications involving droplet detachment from solid surfaces, it is vital to study the droplet characteristics (e.g., contact angle and base width) when the droplet is experiencing the maximum force that detaches the droplet (maximum adhesion state).

A rare case report of an solitary neurofibroma in postcricoid region of hypopharynx.

Rationale: Postcricoid neurofibroma is an extremely rare hypopharynx tumor that can be challenging in both diagnosis and treatment. This case sheds light on the possibility of treatment with transoral microsurgery before pursuing open cervical incisions.

Patient Concerns: : A 43-year-old man presented with a four months history of a persistent foreign body sensation and mild dysphagia.

Mechanistic study on calcium ion diffusion into fayalite: A step toward sustainable management of copper slag.

Copper slag, which contains Fe-rich fayalite (FeSiO), is a valuable solid waste that warrants further research in order to recover iron. Calcium oxide (CaO) can significantly enhance iron recovery from copper slag; however, the associated mechanism has not yet been explored. In this study, we investigated the interaction between CaO and FeSiO to obtain detailed understanding of the role of CaO in enhancing iron recovery.

Tetrandrine partially reverses multidrug resistance of human laryngeal cancer cells.

Objective: Studies have demonstrated that tetrandrine reverses multidrug resistance (MDR) in animal models or cell lines derived from multiple cancer types. We examined the potential MDR reversal activity of tetrandrine in a multidrug-resistant variant of a human laryngeal cancer Hep-2 cell line and explored potential mechanisms involved.

Methods: We developed the multidrug-resistant variant cell line (Hep-2/v) by exposing Hep-2 cells to stepwise increasing concentrations of vincristine (VCR).

Integrated analysis revealing genome-wide chromosomal copy number variation in supraglottic laryngeal squamous cell carcinoma.

Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribute to the genetic diversity of tumor pathogenesis.

Multiple symmetric lipomatosis with secondary laryngeal obstruction: A case report.

Introduction: Multiple symmetric lipomatosis (MSL) is an uncommon medical condition characterized by symmetric fat accumulation mainly in the neck and other upper body regions. The involvement of the larynx is rare according to the literature, and we present a case of MSL with larynx involvement treated with a surgical approach.

Patient Concerns: A 55-year-old male was admitted to our hospital due to progressively aggravated breathing difficulty, and tracheotomy was performed before transfer.

Selective adsorption of a high-performance depressant onto dolomite causing effective flotation separation of magnesite from dolomite.

This research focused on the adsorption features and depression mechanism of 1-hydroxyethylene-1,1-diphosphonic acid (HEDP) used as a novel dolomite depressant on dolomite and magnesite surfaces, to extend the application of HEDP for the selective flotation of magnesite from dolomite. The depression impacts of HEDP on the flotation behaviors of the two minerals were investigated through micro-flotation tests. The flotation results indicated that, when sodium oleate (NaOl) was used as the collector, HEDP displayed an outstanding depression effect on the dolomite flotation, whereas it had only a slight influence on the magnesite flotation.

Isothermal Coal-Based Reduction Kinetics of Fayalite in Copper Slag.

The coal-based reduction of fayalite was characterized using thermogravimetric (TG) and differential TG methods with reduction temperatures from 1123 to 1273 K. The results of fayalite isothermal reduction indicate that the reduction process is divided two stages. The corresponding apparent activation energy was gained using the isoconversional and model-fitting methods.

Mechanical property and structural evolution of alkali-activated slag-phosphate mine tailings mortars.

The present work studies consolidation of phosphate mine tailings through alkaline activation process with the addition of slag for adjusting the gel structure. As increasing slag contents in the raw materials, more (Na,K)O-CaO-AlO-SiO-HO (C-A-S-H) and (Na,K)O-AlO-SiO-HO (N-A-S-H) gels were formed in the mine tailings-based mortars. Compressive strength of the mortars increased as increasing the slag contents from 0 to 40%, and then it kept a plateau.

Contact Line and Adhesion Force of Droplets on Concentric Ring-Textured Hydrophobic Surfaces.

Advances made in fabrication of patterned surfaces with well-defined dimensions of topographic features and their lateral dissemination drive the progress in interpretation of liquid spreading, adhesion, and retreat on engineered solid surfaces. Despite extensive studies on liquid droplet spreading and adhesion on textured surfaces in recent years, conformation of the three-phase contact line and its effect on macroscopic contact angle and droplet adhesion remain the focus of intensive debate. Here, we investigate the effect of surface topography on the adhesion force of Cassie-Baxter-state droplets on concentric ring-textured hydrophobic surfaces having rings with lateral dimensions of 5, 10, and 45 μm and separated by 5, 6, and 7 μm trenches, respectively, with fixed depth of 15 μm.

Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation.

Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of pepsin in HPSCC is not clear. We show by immunohistochemistry that pepsin positivity occurs in a significant proportion of human primary HPSCC specimens, and in many cases matched adjacent uninvolved epithelia are negative for pepsin.

Failure of standard methods for retrieving an unusual foreign body in esophagus: A case report.

Rationale: The ingestion of a foreign body (FB) with complete impaction of the esophagus is not common. Here we report a rare case of successful retrieval of a spherical stone in the esophagus of a man with mental retardation, using gallbladder grasping forceps and rigid endoscope.

Patient Concerns: A mental retarded man came to the emergency department presenting with recurrent nausea, vomiting, and dysphagia after swallowing a spherical stone.

A case of metastasis of small cell lung cancer to the parotid gland: a case report and literature review.

Small cell lung cancer metastasizing to the parotid gland is very rare and only a few cases have been reported. A 64-year-old man presented with a painless mass and peripheral facial paralysis. Neck ultrasound identified a solid mass in the right parotid gland with enlargement of the lymph nodes in the gland and the right submandibular lymph nodes.

Improvement Effect of FeSO·7HO on Flotation Separation of Scheelite from Fluorite.

In this study, FeSO·7HO was used as an auxiliary depressant to improve the selective depression effect on fluorite. Microflotation tests using oleic acid as the collector showed that the pre-addition of FeSO·7HO and subsequent addition of sodium silicate (SS) resulted in a stronger selective depression effect on fluorite compared with SS alone. Addition of FeSO·7HO reduced the required dosage of SS and had little negative effects on scheelite recovery.

Association Between Matrix Metalloproteinase-1, 2, 3 Polymorphisms and Oral Cancer Risk: A Meta-Analysis.

Purpose: Numerous studies have estimated the association between matrix metalloproteinases (MMPs) polymorphisms and the risk of oral cancer; the results, however, are inconsistent and conflicting. Therefore, we conducted a meta-analysis to evaluate the association of MMP-1, 2, and 3 polymorphisms with oral cancer risk.

Methods: A computerized literature search was conducted of electronic databases and search engines.

Growth Inhibition Effect and Validation of Stable Expressed Reference Genes for Near-Infrared Photothermal Therapy Mediated by Gold Nanoflower Particles on Human Tongue Carcinoma Tca-8113 Cells.

Compared with surgery, radiotherapy, chemotherapy and other conventional cancer treatments, near-infrared (NIR) photothermal therapy mediated by gold nanoparticles had advantages of non-invasive, safe, non-drug resistance and small side effects. Especially for tongue cancer and other head and neck tumors, NIR gold nanoparticle-mediated photothermal therapy is more conducive to preserve the anatomic and functional integrity of stomatognathic system, improving the life quality of patients. However, the toxic organic phase substances are commonly used in conventional gold nanoparticles preparation process in order to increase the stability of the material which limited its application in the biomedical field.

Indocyanine Green-Loaded Gold Nanoflowers@Two Layers of Silica Nanocomposites for Photothermal and Photodynamic Therapy of Oral Carcinoma.

Both photothermal therapy (PTT) and photodynamic therapy (PDT) are phototherapeutic approaches, which have been widely investigated for cancer therapy mediated by near infrared (NIR) light irradiation. Here, we successfully constructed a single-light triggered indocyanine green (ICG)-loaded gold nanocomposites which were composed of gold nanoflower core/two layers silica shell (AuNFs@SiO₂@mSiO₂-ICG) for enhanced PDT/PTT synergistic effect to oral carcinoma. The AuNFs@SiO₂@mSiO₂-ICG nanocomposites had no obviously cytotoxicity and could effectively arrest Cal27 cells in the G1 phase.

Resveratrol attenuates CoCl2-induced cochlear hair cell damage through upregulation of Sirtuin1 and NF-κB deacetylation.

The goals of this study were to investigate the effects of hypoxia on cochlear hair cell damage, and to explore the role of sirtuin1 in hypoxia-induced hair cell damage. Cochlear organotypic cultures from postnatal day 4 rats were used in this study. Hypoxia was induced by treating cochlear explants with CoCl2.

Blocked autophagy enhances radiosensitivity of nasopharyngeal carcinoma cell line CNE-2 in vitro.

Conclusion: Autophagy was involved in the radiation treatment of CNE-2 cells, and blocked autophagy enhances the radiosensitivity of nasopharyngeal carcinoma cell line CNE-2 in vitro.

Objective: To determine whether autophagy induced by radiation therapy contributes to tumor cell death or represents a mechanism of resistance to therapy-mediated cell death.

Methods: Autophagy in the CNE-2 nasopharyngeal carcinoma cells after radiation treatment was determined by quantitative GFP-LC3 analysis, electron microscopy, and autophagy-related molecules analysis by Western blotting.