DNMT3b-mediated CpA methylation facilitates REST binding and gene silencing and exacerbates hippocampal demyelination in diabetic mice.

The remyelination process within the diabetes mellitus (DM) brain is inhibited, and dynamic interactions between DNA methylation and transcription factors are critical for this process. Repressor element-1 silencing transcription factor (REST) is a major regulator of oligodendrocyte differentiation, and the role of REST on DM remyelination remains to be investigated. Here, we investigated the effects of REST and DNA methylation on DM remyelination and explored the underlying mechanisms.

The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside.

Diabetic cognitive dysfunction (DCD) is a complication of diabetes that seriously affects quality of life. Glucocorticoid-induced transcript 1 (GLCCI1) has been found to be involved in inflammation, apoptosis and autophagy in various diseases. However, the distribution of GLCCI1 in the brain and its role in DCD have not yet been revealed.

Identification of HMMR as a prognostic biomarker for patients with lung adenocarcinoma integrated bioinformatics analysis.

Background: Lung adenocarcinoma (LUAD) is the most prevalent tumor in lung carcinoma cases and threatens human life seriously worldwide. Here we attempt to identify a prognostic biomarker and potential therapeutic target for LUAD patients.

Methods: Differentially expressed genes (DEGs) shared by GSE18842, GSE75037, GSE101929 and GSE19188 profiles were determined and used for protein-protein interaction analysis, enrichment analysis and clinical correlation analysis to search for the core gene, whose expression was further validated in multiple databases and LUAD cells (A549 and PC-9) by quantitative real-time PCR (qRT-PCR) and western blot analyses.

In vivo oral bioavailability of fish mercury and comparison with in vitro bioaccessibility.

Fish consumption is considered to be a major human exposure route for mercury (Hg), but assessing the actual Hg bioavailability from consumed fish is challenging. In this study, we conducted both in vivo bioavailability (using a mouse model) and in vitro bioaccessibility (using various gastrointestinal digestion methods) assessments of Hg from consumed fish. Lyophilized fish muscles which already absorbed Hg through natural incorporation were introduced to mice by active feeding.

Inter-species differences of total mercury and methylmercury in farmed fish in Southern China: Does feed matter?

China is now the largest producer of marine farmed fish and there is a considerable concern of seafood safety due to potential mercury contamination. We analyzed both the total mercury (THg) and methylmercury (MeHg) concentrations in nine species of commercial fish from two marine-cage farms in Southern China. C and N stable isotopes were concurrently analyzed to identify the artificial feed sources and the trophic levels of farmed fish.

Tuning aluminum spatial distribution in ZSM-5 membranes: a new strategy to fabricate high performance and stable zeolite membranes for dehydration of acetic acid.

A novel ZSM-5 membrane with a low Si/Al ratio and homogeneous aluminum spatial distribution was achieved from an organic template-free inorganic gel in the presence of both OH(-) and F(-) ions and the obtained ZSM-5 membrane exhibited excellent selectivity and high flux and stability for dehydration of acetic acid in a wide AcOH content range.