Publications by authors named "Wanyue Gu"
Int J Biol Macromol
November 2024
Article Synopsis
- Intratumoral injection of CAR-T cells for melanoma treatment offers reduced systemic side effects and higher CAR-T cell concentration, but challenges like few targeting ligands and a tough tumor microenvironment (TME) hinder effectiveness.
- A novel nanogel, HA-Mn-CAP Gel, was developed to target receptors in melanoma, releasing manganese to alleviate tumor hypoxia and boost CAR-T cell ligand expression, showing over a 2.7 times increase in NKGD ligand levels in melanoma cells.
- When combined with CAR-T therapy, HA-Mn-CAP Gel enhanced T cell proliferation and infiltration, increasing tumor inhibition rates significantly, suggesting this approach could improve therapies for solid tumors.
