Publications by authors named "Wanyuan Ruan"
The pancreatic stellate cells (PSCs) play an important role in the development of pancreatic cancer (PC) through mechanisms that remain unclear. Exosomes secreted from PSCs act as mediators for communication in PC. This study aimed to explore the role of PSC-derived exosomal small RNAs derived from tRNAs (tDRs) in PC cells.
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- Inflammation and ferroptosis play important roles in the immune microenvironment of hepatocellular carcinoma (HCC), impacting the effectiveness of immunotherapy.
- Researchers identified seven key biomarkers (including ADH4 and APOA5) from inflammation-associated ferroptosis (IAF) genes to create a risk model that differentiates HCC patients into high-risk and low-risk groups.
- The high-risk group showed shorter survival times, increased immune scores, and a better predicted response to immune checkpoint inhibition therapy, suggesting these biomarkers can improve diagnosis and treatment strategies for HCC.
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- Scientists studied a type of brain tumor called glioma that has a common mutation called IDH1.
- They looked for specific markers to help identify these mutated gliomas by analyzing data from two large cancer databases.
- They found a risk model that can predict how well patients with IDH1-mutated glioma will do, showing that those with higher scores may have a worse outcome.
Hypoxia promotes the progression of hepatocellular carcinoma. However, the hypoxia regulatory network in hepatocellular carcinoma is known to be limited. Thus, this study aimed to identify the crucial hypoxia-associated genes and to explore their effects and molecular mechanisms in hepatocellular carcinoma cells.
View Article and Find Full Text PDFBackground: It was recently reported that lncRNA FBXL19 antisense RNA 1 (FBXL19-AS1) is a novel tumor-promoting RNA that contributes to tumor progression by sponging miRNAs. However, the expression and function of FBXL19-AS1 in osteosarcoma (OS) have not been investigated.
Methods: Cell proliferation was assessed by the CCK-8 and colony formation assays, while cell migration and invasion were assessed using wound healing and transwell invasion assays, respectively.
CDH11 promotes liver fibrosis via activation of hepatic stellate cells.
Biochem Biophys Res Commun
January 2019
Liver fibrosis, an important health condition associated with chronic liver injury that provides a permissive environment for cancer development, is characterized by the persistent deposition of extracellular matrix components that are mainly derived from activated hepatic stellate cells (HSCs). CDH11 belongs to a group of transmembrane proteins that are principally located in adherens junctions. CDH11 mediates homophilic cell-to-cell adhesion, which may promote the development of cirrhosis.
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