A review of fine-grained sketch image retrieval based on deep learning.

Sketch image retrieval is an important branch of the image retrieval field, mainly relying on sketch images as queries for content search. The acquisition process of sketch images is relatively simple and in some scenarios, such as when it is impossible to obtain photos of real objects, it demonstrates its unique practical application value, attracting the attention of many researchers. Furthermore, traditional generalized sketch image retrieval has its limitations when it comes to practical applications; merely retrieving images from the same category may not adequately identify the specific target that the user desires.

Striatal D Dopamine Neuronal Population Dynamics in a Rat Model of Levodopa-Induced Dyskinesia.

Background: The pathophysiology of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) is not well understood. Experimental data from numerous investigations support the idea that aberrant activity of D dopamine receptor-positive medium spiny neurons in the striatal direct pathway is associated with LID. However, a direct link between the real-time activity of these striatal neurons and dyskinetic symptoms remains to be established.

A computational method for predicting nucleocapsid protein in retroviruses.

Nucleocapsid protein (NC) in the group-specific antigen (gag) of retrovirus is essential in the interactions of most retroviral gag proteins with RNAs. Computational method to predict NCs would benefit subsequent structure analysis and functional study on them. However, no computational method to predict the exact locations of NCs in retroviruses has been proposed yet.

Inhibition of striatal dopamine D receptor attenuates levodopa-induced dyskinesia in a rat model of Parkinson's disease.

Levodopa-induced dyskinesia (LID) is experienced by most patients of Parkinson's disease (PD) upon the long-term use of the dopamine precursor levodopa. Striatal dopaminergic signaling plays a critical role in the pathogenesis of LID through its interactions with dopamine receptors. The specific roles of striatal dopaminergic D receptors in the pathophysiological process of LID are still poorly established.

The upregulation of EGFR in the dorsal root ganglion contributes to chronic compression of dorsal root ganglions-induced neuropathic pain in rats.

The epidermal growth factor receptor (EGFR) located in dorsal root ganglion has been found as a new target for chronic pain treatment. However, it is not clear whether the change of EGFR expression in the dorsal root ganglion contributes to neuropathic pain development. In this study, we used a chronic compression of unilateral lumbar dorsal root ganglions (CCD)-induced rat neuropathic pain model and found that CCD caused the upregulation of both phosphorylated EGFR and total EGFR expression in compressed lumbar 4/5 (L4/L5) dorsal root ganglions by western blotting and immunohistochemistry methods.