Risk stratification for 1- to 2-cm gastric gastrointestinal stromal tumors: visual assessment of CT and EUS high-risk features versus CT radiomics analysis.

Objectives: To investigate the ability of CT and endoscopic sonography (EUS) in predicting the malignant risk of 1-2-cm gastric gastrointestinal stromal tumors (gGISTs) and to clarify whether radiomics could be applied for risk stratification.

Methods: A total of 151 pathologically confirmed 1-2-cm gGISTs from seven institutions were identified by contrast-enhanced CT scans between January 2010 and March 2021. A detailed description of EUS morphological features was available for 73 gGISTs.

Preoperative prediction of malignant potential of 2-5 cm gastric gastrointestinal stromal tumors by computerized tomography-based radiomics.

Background: The use of endoscopic surgery for treating gastrointestinal stromal tumors (GISTs) between 2 and 5 cm remains controversial considering the potential risk of metastasis and recurrence. Also, surgeons are facing great difficulties and challenges in assessing the malignant potential of 2-5 cm gastric GISTs.

Aim: To develop and evaluate computerized tomography (CT)-based radiomics for predicting the malignant potential of primary 2-5 cm gastric GISTs.

A Quantitative Analysis of Drug Loading Efficiency and Real-Time Drug Release in ZrO₂ Nanoparticles with Energy Spectrum Computed Tomography.

Energy spectrum computed tomography (CT) can quantify the concentrations of substances and In this study, we designed a single-shell system of doxorubicin (DOX) loaded in zirconium dioxide nanoparticles (DOX@ZrO₂ NPs) as a novel chemotherapy drug delivery system. The concentration of DOX@ZrO₂ NPs in tissue was monitored with energy spectrum CT to calculate the release of DOX from the NPs. The standard curve of the gradient concentrations of ZrO₂ NPs and base material content fit a logarithmic equation.

TMEM16A Protein: Calcium-Binding Site and its Activation Mechanism.

TMEM16A mediates the calcium-activated transmembrane flow of chloride ions and a variety of physiological functions. The binding of cytoplasmic calcium ions of TMEM16A and the consequent conformational changes of it are the key issues to explore the structure-function relationship. In recent years, researchers have explored this issue through electrophysiological experiments, structure resolving, molecular dynamic simulation, and other methods.

Could computed tomography be used as a surrogate of endoscopic ultrasonography in the screening and surveillance of small gastric Gastrointestinal stromal tumors?

Purpose: To investigate whether computed tomography (CT) could be used for screening and surveillance of small gastric gastrointestinal stromal tumors (gGISTs).

Method: A total of 162 pathologically confirmed small gGISTs (≤2 cm) between September 2007 and November 2019 were retrospectively enrolled. Thirty-six lesions received contrast-enhanced CT after they were identified by endoscopy and EUS, and forty-three lesions received CT alone before surgery.

Desmoid-type fibromatosis: Tumour response assessment using magnetic resonance imaging signal and size criteria.

Introduction: This study aimed to establish a specified magnetic resonance imaging (MRI) signal and size criterion for assessing the response of desmoid-type fibromatosis (DF).

Methods: This retrospective study included 129 patients with DF who received non-surgical therapy. All patients underwent pretreatment and 6-month-interval follow-up MRI for >3 years (6 follow-up visits).

A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7.

The LIN28:pre-let-7:TUTase ternary complex regulates pluripotency and oncogenesis by controlling processing of the let-7 family of microRNAs. The complex oligouridylates the 3' ends of pre-let-7 molecules, leading to their degradation via the DIS3L2 exonuclease. Previous studies suggest that components of this complex are potential therapeutic targets in malignancies that aberrantly express LIN28.

Intelligent Detection Platform for Simultaneous Detection of Multiple MiRNAs Based on Smartphone.

As a marker of malignant tumors, miRNA is closely related to the occurrence and metastasis of tumors. How to achieve rapid and sensitive real-time detection is important for clinical prevention and treatment of cancer. In this study, an intelligent detection platform based on smartphone image processing technology made point-of-care testing a reality.

Near-infrared light remotely up-regulate autophagy with spatiotemporal precision via upconversion optogenetic nanosystem.

In vivo noninvasively manipulating biological functions by the mediation of biosafe near infrared (NIR) light is becoming increasingly popular. For these applications, upconversion rare-earth nanomaterial holds great promise as a novel photonic element, and has been widely adopted in optogenetics. In this article, an upconversion optogenetic nanosystem that was promised to achieve autophagy up-regulation with spatiotemporal precision was designed.

Shape Coding Microhydrogel for a Real-Time Mycotoxin Detection System Based on Smartphones.

How to create a portable and quick way to detect multiple coexisting toxins is closely related to everyone's health. In this paper, we have established a real-time mycotoxin detection system that combined shape-encoded hydrogel particle preparation technology and image processing technology with smartphone portable devices. First, hydrogel microparticles containing a specific recognition toxin aptamer were programmable synthesized by stop-flow lithography.

Development of a novel rat model of heterogeneous hepatic injury by injection with colchicine the splenic vein.

Aim: To develop a novel rat model of heterogeneous hepatic injury.

Methods: Seventy male Sprague-Dawley rats were randomly divided into a control group ( = 10) and a colchicine group ( = 60). A 0.

Near-Infrared Light-Excited Upconverting Persistent Nanophosphors in Vivo for Imaging-Guided Cell Therapy.

Optical imaging for biological applications is in need of more sensitive tool. Persistent luminescent nanophosphors enable highly sensitive in vivo optical detection and almost completely avoid tissue autofluorescence. Nevertheless, the actual persistent luminescent nanophosphors necessitate ex vivo activation before systemic operation, which severely restricted the use of long-term imaging in vivo.

Targeted delivery of tungsten oxide nanoparticles for multifunctional anti-tumor therapy via macrophages.

Tumor-associated macrophages are highly versatile effector cells that have been used to kill tumor cells. Herein, the macrophages as cell-based biocarriers are used for the targeted delivery of photothermal reagents for promoting the efficiency of killing tumor cells by activating the anti-tumor immune response and photothermal therapy (PTT). In this design, macrophages cause the phagocytosis of tumor cells and activate the anti-tumor immune response by secreting plenty of cytokines.

Near-Infrared Light Triggered Upconversion Optogenetic Nanosystem for Cancer Therapy.

In vivo the application of optogenetic manipulation in deep tissue is seriously obstructed by the limited penetration depth of visible light that is continually applied to activate a photoactuator. Herein, we designed a versatile upconversion optogenetic nanosystem based on a blue-light-mediated heterodimerization module and rare-earth upconversion nanoparticles (UCNs). The UCNs worked as a nanotransducer to convert external deep-tissue-penetrating near-infrared (NIR) light to local blue light to noninvasively activate photoreceptors for optogenetic manipulation in vivo.

A visual guide to gene/optothermal synergy therapy nanosystem using tungsten oxide.

Combination of gene therapy and photothermal therapy (PTT) has drawn much attention in cancer therapy in recent years. However, this joint treatment process lacks fluorescence imaging visualization guidance that limits its clinical applications in oncotherapy. Herein, we report the use of gene therapy and tungsten oxide (WO, WO) synthetized with template method for combined PTT of cancer.

Near-infrared persistent luminescence phosphors ZnGaO:Cr as an accurately tracker to photothermal therapy in vivo for visual treatment.

The photothermal therapy agents induced by 808 nm near infrared light laser have good potential for photothermal therapy (PTT) in vivo, with the advantages of harmless treatment, minimally invasion, high efficiency and deep tissue penetration. For the traditional photothermal therapy agents, however, it was impossible to track them in vivo because of the low signal-to-noise ratio, so we cannot conduct the extra near infrared light laser to radiate tumors sites accurately. Herein, we introduce a new complex: indocyanine green (ICG), near-infrared persistent luminescence (PL) phosphors ZnGaO:Cr (ZGC) and mesoporous silica nanoparticles (MSNs) (ICG@mZGC nanoparticles) were assembled for long-lasting optical imaging to guide PTT.