Serum copper and obesity among healthy adults in the National Health and Nutrition Examination Survey.

Background: Copper (Cu) homeostasis are important processes in the cause of metabolic diseases, but the association between Cu and obesity remains unclear.

Methods: Participants were drawn from the 2011-2016 National Health and Nutrition Examination Survey (NHANES). Weighted logistic regression assessed the associations of serum Cu concentrations (tertiles) with obesity and central obesity in individuals without comorbidities.

Performance of ChatGPT on the Chinese Postgraduate Examination for Clinical Medicine: Survey Study.

Background: ChatGPT, an artificial intelligence (AI) based on large-scale language models, has sparked interest in the field of health care. Nonetheless, the capabilities of AI in text comprehension and generation are constrained by the quality and volume of available training data for a specific language, and the performance of AI across different languages requires further investigation. While AI harbors substantial potential in medicine, it is imperative to tackle challenges such as the formulation of clinical care standards; facilitating cultural transitions in medical education and practice; and managing ethical issues including data privacy, consent, and bias.

How does ChatGPT-4 preform on non-English national medical licensing examination? An evaluation in Chinese language.

ChatGPT, an artificial intelligence (AI) system powered by large-scale language models, has garnered significant interest in healthcare. Its performance dependent on the quality and quantity of training data available for a specific language, with the majority of it being in English. Therefore, its effectiveness in processing the Chinese language, which has fewer data available, warrants further investigation.

B-Cell Translocation Gene 2 Upregulation Is Associated with Favorable Prognosis in Lung Adenocarcinoma and Prolonged Patient Survival.

The tumor suppressor protein B-cell translocation gene 2 (BTG2) is downexpressed in lung adenocarcinoma (LUAD); however, its role in LUAD survival remains unknown. This investigation is aimed at exploring the activity of BTG2 in LUAD. We analyzed BTG2 expression in LUAD datasets of the TCGA database and examined that BTG2 was markedly downregulated in comparison with adjacent normal tissues.

Transmissible Endoplasmic Reticulum Stress Mediated by Extracellular Vesicles from Adipocyte Promoting the Senescence of Adipose-Derived Mesenchymal Stem Cells in Hypertrophic Obesity.

Hypertrophic obesity, characterized by an excessive expansion of subcutaneous adipocytes, causes chronic inflammation and insulin resistance. It is the primary feature of obesity in middle-aged and elderly individuals. In the adipose microenvironment, a high level of endoplasmic reticulum (ER) stress and changes in the extracellular vesicle (EV) composition of adipocytes may cause the senescence and restrained differentiation of progenitor cells of adipose, including adipose-derived mesenchymal stem cells (ASCs).

piRNA-14633 promotes cervical cancer cell malignancy in a METTL14-dependent m6A RNA methylation manner.

Background: Cervical cancer (CC) is one of the most common gynecological tumors that threatens women's health and lives. Aberrant expression of PIWI-interacting RNA (piRNA) is closely related with a range of cancers and can serve as a tumor promoter or suppressor in proliferation, migration and invasion. In this study, the aim was not only to discover differential expression of piRNA in CC tissue (CC cells) and normal cervical tissue (normal cervical epithelium cells), but also to investigate the biological function and action mechanism of piRNA in CC.

ZIF-67-derived CoO hollow nanocage with efficient peroxidase mimicking characteristic for sensitive colorimetric biosensing of dopamine.

CoO hollow nanocages (CoO HNCs) were prepared by simple calcination with ZIF-67 as the precursor. Compared with ordinary nano-sized CoO, skeletal CoO HNCs have a larger specific surface area and porosity, lead to better dispersion, which can expose more catalytic active sites, and obtain higher catalytic activity. Experiments indicate that CoO HNCs are used as a catalyst to make HO generate O.

Colorimetric and Raman spectroscopic array for detection of hydrogen peroxide and glucose based on etching the silver shell of Au@Ag core-shell nanoparticles.

Gold-silver core-shell nanoparticles (Au@Ag NPs) were prepared by two successive reductions in a seed-growth method. The Au@Ag NPs are used as both a colorimetric and Raman spectroscopic probe for ultrasensitive determination of HO and glucose. It is found that HO (as produced from glucose by the action of glucose oxidase) can directly oxidize and gradually corrode the silver shell of the Au@Ag NPs.

The complete mitochondrial genome of (Aulodonta: diadematidae).

The complete mitochondrial genome of was sequenced by using long-PCR and primer walking methods. The complete mitochondrial genome is a 15,708 bp circular molecule, which contains 22 tRNAs, 2 rRNAs, and 13 protein-coding genes as well as a non-coding control region as in other urchin. The genome was composed of 27.

The complete mitochondrial genome of Temnopleurus hardwickii (Camarodonta: Temnopleuridae).

The complete mitochondrial genome of Temnopleurus hardwickii was sequenced using long-PCR and primer walking methods. The complete mitochondrial genome is a 15,696 bp circular molecule which contains 22 tRNAs, 2 rRNAs, 13 protein-coding genes as well as a non-coding control region as in other urchin. The genome was composed of 32.