Baseline absolute lymphocyte count as a prognostic indicator in advanced or metastatic breast cancer: a systematic review and meta-analysis.

This study used meta-analysis to examine the role of baseline absolute lymphocyte count (ALC) in the prognosis of advanced breast cancer (ABC) or metastatic breast cancer (MBC). A comprehensive search encompassing PubMed, The Cochrane Library, Embase, and Web of Science databases was undertaken to identify and screen literature based on predefined inclusion and exclusion criteria. Progression-free survival (PFS), time to treatment failure (TTF), post-progression survival (PPS), and overall survival (OS) were selected as outcome measures.

Effect of Intravenous Thrombolytic Dose of Alteplase on Long-Term Prognosis in Patients with Acute Ischemic Stroke.

Introduction: This study aimed to investigate the long-term prognostic effects of different alteplase doses on patients with acute ischemic stroke (AIS).

Methods: In this cohort study, we enrolled 501 patients with AIS treated with intravenous thrombolysis with alteplase, with the primary endpoint event of recurrence of ischemic stroke and the secondary endpoint event of death. The effects of different doses of alteplase on recurrence of ischemic stroke and death were analyzed using a Cox proportional risk model.