Publications by authors named "Wanyi Pan"

Overexpression of coactivator associated arginine methyltransferase 1 (CARM1) is associated with various diseases including cancer. Therefore, CARM1 has emerged as an attractive therapeutic target and a drug response biomarker for anticancer drug discovery. However, the development of conventional CARM1 inhibitors has been hampered by their limited clinical efficacy, acquired resistance, and inability to inhibit nonenzymatic functions of CARM1.

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Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators ( inhibitors). However, epigenetic inhibitors have faced multiple challenges, including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance.

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Article Synopsis
  • Histone methyltransferases (HMTs) are important in regulating gene activity and are associated with various diseases, particularly cancer, making them potential targets for cancer therapy.
  • Despite interest in developing HMT inhibitors over the last decade, challenges like limited effectiveness, moderate selectivity, and risk of drug resistance have slowed progress.
  • The review highlights key HMTs, their functions in cancer, and recent advancements in HMT modulator development, while also addressing ongoing challenges and future research directions in HMT-targeted cancer treatments.
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In this study, a novel series of histone deacetylases 6 (HDAC6) inhibitors containing polycyclic aromatic rings were discovered and evaluated for their pharmacological activities. The most potent compound exhibited high HDAC6 inhibitory activity (IC = 261 nM) and excellent HDAC6 selectivity (SI = 109 for HDAC6 over HDAC3). also showed decent antiproliferative activity with IC of 7.

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A series of novel acridane-based tubulin polymerization inhibitors were designed, synthesized, and bioevaluated as anticancer agents. The most potent compound exhibited high tubulin polymerization inhibitory activity (IC = 1.5 μM) and remarkable antiproliferative potency against four cancer cell lines with an average IC of 30 nM, better than colchicine and the hit compound (IC of 65 and 126 nM, respectively).

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Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP represents a promising strategy for cancer therapy. To date, numerous small molecule PARP1 inhibitors have been identified, but many of them suffer from limited clinical efficacy and serious toxicity.

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Angelica pubescens, a plant of the family Umbelliferae, has been widely used as traditional Chinese medicine for the treatment of many diseases. However, there has been minimal modern research focused on the pharmacological activity of oils extracted from Angelica pubescens, in particular, the potential anti-photoaging effects. Therefore, in the present study, we analyzed the chemical composition of Angelica pubescens oil (AO) and evaluated its bioactivity against photoaging in ultraviolet (UV) -B radiation-induced hairless mice.

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Chemical compositions, antioxidative, antimicrobial, anti-inflammatory, and cytotoxic activities of essential oils extracted from four common Curcuma species (Curcuma longa, Curcuma phaeocaulis, Curcuma wenyujin, and Curcuma kwangsiensis) rhizomes in P. R. China are comparatively studied.

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Genus Curcuma a wild species presents an important source of valuable characters for improving the cultivated Curcuma varieties. Based on the collected germplasms, herbariums, field surveys and other literatures, the ecogeographical diversity of Genus Curcuma and its potential distributions under the present and future climate are analysed by DIVA-GIS. The results indicate Genus Curcuma is distributed over 17 provinces in China, and particularly abundant in Guangxi and Guangdong provinces.

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Objective: To evaluate the bias of three different methods in determination of glycated hemoglobin A1c (HbA1c).

Methods: According to Clinical and Laboratory Standards Institute (CLSI)EP9-A3 document, 40 serum specimens among linear range were tested by immunoturbidimetry assay (Roche Tina-quant), capillary electrophoresis (Sebia Minicap FP), high performance liquid chromatography system (HPLC, Trinity Biotech Premier Hb 9210™). RESULTS were analyzed by pairwise comparision.

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