Publications by authors named "Wanyi Dang"

is a LIM-homeodomain transcription factor that affects body size in mammals by regulating the secretion of pituitary hormones. Akita, Shiba Inu, and Mame Shiba Inu dogs are Japanese native dog breeds that have different body sizes. To determine whether plays a role in the differing body sizes of these three dog breeds, we sequenced the gene in the three breeds, which led to the identification of an SNP in codon 280 (S280N) associated with body size.

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Article Synopsis
  • - The study focuses on the body size differences between the Shiba Inu and the smaller "Mame Shiba Inu," highlighting how artificial selection has influenced this trait.
  • - Whole genome sequencing was performed, revealing over 13 million unique SNPs between the two dog breeds and identifying 12 genomic regions associated with selection.
  • - The research identifies nine candidate genes potentially linked to body size, with eight being novel and requiring further investigation, while some genes are already known to be related to body size in other mammals.
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  • The study investigates the microbial composition and functions of the donkey's intestines, highlighting the differences between the small and large intestine.
  • Firmicutes and Bacteroidetes are the predominant bacterial groups, with distinct communities: starch-degrading bacteria are more common in the small intestine while fiber-degrading bacteria are abundant in the large intestine.
  • Findings suggest that the small intestine is involved in membrane transport and lipid metabolism, while the large intestine specializes in energy and amino acid metabolism; overall, this research enhances our understanding of donkeys’ gut health and their digestive system evolution.
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Through domestication and human selection, horses have acquired various coat colors, including seven phenotypes: black, brown, dark bay, bay, chestnut, white, and gray. Here we determined the genotypes for melanocortin-1 receptor (MC1R) and agouti signaling protein (ASIP) in 709 horses from 15 breeds. We found that the EEEE genotype frequency at MC1R decreased from dark to light colors (black = 64.

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Synopsis of recent research by authors named "Wanyi Dang"

  • - Wanyi Dang's research focuses on the genetic underpinnings of body size variation among domestic animals, particularly Japanese dog breeds, through studies involving nonsynonymous substitutions and whole genome sequencing.
  • - Significant findings include the identification of an SNP in the gene associated with body size differences among Akita, Shiba Inu, and Mame Shiba Inu breeds, indicating genetic selection's role in artificial size variation.
  • - Additionally, Dang has explored the intestinal microbiome of donkeys, emphasizing its biogeography and functional characteristics, as well as investigated coat color genetics in horses, highlighting the interplay of specific genes in determining phenotypic traits.

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