Epicatechin-mediated modulation of the Nrf2/HO-1 pathway alleviates senile cerebral ischemic/reperfusion injury.

Excessive reactive oxygen species (ROS) generated during cerebral ischemic reperfusion (CIRI) are crucial for subsequent tissue damage. However, despite the potential benefits of antioxidants reported in clinical applications, few have proven effective in treating CIRI, particularly in the elderly. Epicatechin (EC) is a catechol flavonoid monomer derived from natural tea plants.

PD98059 protects SH-SY5Y cells against oxidative stress in oxygen-glucose deprivation/reperfusion.

Mitochondria play a key role in the cerebral ischemia-reperfusion injury. Although the extracellular signal-regulated kinase 1/2 inhibitor PD98059 (PD) is a selective and reversible flavonoid that can protect the mitochondria in a rat model of cardiac arrest/cardiopulmonary resuscitation, its role requires further confirmation. In this study, we investigated whether PD could maintain mitochondrial homeostasis and decrease reactive oxygen species (ROS) production in neuroblastoma (SH-SY5Y) cells exposed to oxygen-glucose deprivation/reperfusion (OGD/R).

Pomelo Peel Essential Oil Ameliorates Cerebral Ischemia-Reperfusion Injury through Regulating Redox Homeostasis in Rats and SH-SY5Y Cells.

Background: In cardiac accident/cardiopulmonary resuscitation (CA/CPR) rat model, oxidative stress occurs during cerebral ischemia/reperfusion injury (CIRI), and antioxidative treatment has a neuroprotective effect. The antioxidant capabilities of pomelo peel essential oil (PPEO) have mostly been investigated in vitro, with little convincing data in vivo, particularly whether PPEO has a neuroprotective role against CIRI.

Methods: In this investigation, a CA/CPR SD rat model and an oxygen-glucose deprivation/reperfusion (OGD/R) SH-SY5Y cell model were used to imitate the CIRI, and the neuroprotective role of PPEO was discovered in both.

Energy Release Characteristics and Reaction Mechanism of PTFE/Al/BiO Reactive Materials under Drop-Hammer Test.

To obtain the influence of the BiO particle content of a PTFE/Al/BiO reactive material (later referred to as PAB) on its shock-induced chemical reaction (SICR) characteristics, five kinds of PAB with different BiO contents were prepared; the reaction process in a drop-hammer test, recorded using a high-speed camera, was analyzed. The ignition and reaction mechanisms of PAB under mechanical impact were analyzed based on the thermochemical reaction characteristics and the microstructure. The results show that with an increase in BiO content, the shock-induced chemical reaction duration and the sensitivity of PAB increase, and then decrease.

Effects of Al Particle Size on the Impact Energy Release of Al-Rich PTFE/Al Composites under Different Strain Rates.

Polytetrafluoroethylene (PTFE)/Al reactive material with different aluminum particle sizes were prepared by molding and sintering, and the effect of aluminum particle size on the impact behavior of PTFE/Al reactive material with a mass ratio of 50:50 was investigated. The results show that aluminum particle size has significant effects on the shock-reduced reaction diffusion, reaction speed, and degree of reaction of the PTFE/Al reactive material. At a moderate strain rate, the reaction delay of PTFE/Al increased, and the reaction duration and degree decreased, with the increase of aluminum particle size.

Pomelo peel oil suppresses TNF-α-induced necroptosis and cerebral ischaemia-reperfusion injury in a rat model of cardiac arrest.

Context: Pomelo peel oil (PPO) [ (Burm.) Merr. (Rutaceae)] is reported to possess antioxidant and antimelanogenic activities.

Green Tea Polyphenols Modulated Cerebral SOD Expression and Endoplasmic Reticulum Stress in Cardiac Arrest/Cardiopulmonary Resuscitation Rats.

Background: Reducing cerebral ischemia-reperfusion injury is crucial for improving survival and neurologic outcomes after cardiac arrest/cardiopulmonary resuscitation (CA/CPR). The purpose of this study is to investigate the neuroprotective effects of green tea polyphenols (GTPs) concern with the modulation of endogenous antioxidation and endoplasmic reticulum stress.

Methods: After subjecting to CA/CPR, rats were randomized into the saline group (NS,  = 40) and the GTPs group (GTPs,  = 40) and the GTPs group (GTPs,  = 40) and the GTPs group (GTPs.

Measuring physical performance in university students.

Unlabelled: Physical activity could be an effective way to prevent obesity and cardiovascular disease.

Objective: The aim of our study was to evaluate physical performance in Chinese university students to offer a basis for preventing obesity.

Methods: A cross-sectional study was conducted for evaluate physical performance, including the standing long jump, 50-meter dash, and pull-up/sit-up test.

Inhibition of lipopolysaccharide-mediated rat alveolar macrophage activation in vitro by antiflammin-1.

Antiflammin-1 (AF-1) is a synthetic nonapeptide with a similar sequence to the conserved sequence of CC10 secreted by lung Clara cells. Studies suggest that it is potent inhibitor of inflammation. We investigated the effects and possible mechanisms of AF-1 on LPS-induced alveolar macrophage (AM) activation in vitro.