Publications by authors named "Wanxian Xu"
Lumbar disc herniation (LDH) is a common spinal disease. In recent years, an increasing number of observational studies have reported the impact of inflammatory factors on LDH. By conducting Mendelian randomization (MR) analysis on 91 inflammatory factors, it is possible to reveal their causal relationship with LDH, providing new insights for prevention and treatment strategies.
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- - This study examines the possible link between skin microbiomes and prostate cancer (PCa) using a method called bidirectional Mendelian randomization (MR) alongside meta-analysis to enhance its findings.
- - Researchers analyzed genetic data to investigate the relationship between 150 skin microbiomes and PCa, and found that Neisseria present in dry skin is correlated with an increased risk of developing PCa.
- - The study concluded that Neisseria in dry skin acts as a risk factor for prostate cancer, while other skin microbiomes studied showed no significant association with the disease.
Mendelian study on air pollution and membranous nephropathy outcomes associations.
Medicine (Baltimore)
September 2024
Membranous nephropathy (MN) is an autoimmune disease of the kidney glomerulus, which mainly leads to nephrotic syndrome. This study investigates the associations between air pollution and MN risk and from an epigenomic perspective. In this study, we examine the associations between genetically predicted deoxyribonucleic acid methylation related to air pollution and MN risk.
View Article and Find Full Text PDFBackground: Hyperthyroidism is an endocrine disorder with a relatively low global prevalence but significantly higher incidence among females compared to males. The onset age primarily ranges from 30 to 50, although it is not limited to this age group. Challenges in the treatment of hyperthyroidism include individualized treatment plan formulation, management of side effects, and prediction of disease progression, necessitating comprehensive consideration to achieve more effective therapy and management.
View Article and Find Full Text PDFGastroesophageal reflux disease (GERD) is a common condition worldwide. Despite numerous studies on GERD, the causal relationships between blood/urine metabolites and GERD remain unclear. This study aims to explore the causal relationships between GERD and 35 blood/urine metabolites.
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- * Early detection through mammography and MRI is essential for improving survival rates; advancements in immunophenotyping and immunotherapies, such as CAR-T cell therapy, are enhancing diagnosis and treatment with greater effectiveness and fewer side effects.
- * The study utilizes Mendelian Randomization (MR) to analyze 731 immune cell phenotypes in relation to BC, aiming to generate reliable insights for personalized treatment strategies by minimizing biases usually found in observational studies.
Article Synopsis
- The study investigates the link between hypothyroidism and sexual dysfunction (SD), highlighting that both overt and subclinical hypothyroidism affect sexual functioning differently in men and women.
- Through a meta-analysis of 7 studies with over 2,600 participants, it was found that overt hypothyroidism significantly increases the risk of SD, especially in women, while subclinical hypothyroidism did not show a strong association.
- The study suggests that healthcare providers should be mindful of the risk of sexual dysfunction in female patients with overt hypothyroidism, whereas subclinical hypothyroidism appears to be less of a concern for both genders.