Comparative accuracy assessment of analog and virtual wax-up in prosthetic-driven planning and guided implant surgery: A retrospective cohort study.

Purpose: This retrospective cohort study evaluated the accuracy of analog versus virtual wax-ups in prosthetic-driven planning and guided surgery.

Methods: There were 73 patients with a single missing posterior tooth who underwent either an analog or virtual wax-up design following a prosthetic-driven concept. Intraoral scans of the final restoration were performed 1 year after completion of the restoration.

MnO-mineralized milk exosomes as a novel nanoplatform for glutathione detection.

Exosomes have garnered significant attention in the realms of disease diagnosis and therapeutics, owing to their remarkable biocompatibility. While engineered exosomes have the potential to augment delivery efficiency, targeting specificity, and circulation longevity, the intricacies of sample preparation have often hindered their broader application. In this pioneering study, we introduce a novel nanoplatform by leveraging surface manganese dioxide (MnO) mineralization of milk exosomes.

Large-Scale Isolation of Milk Exosomes for Skincare.

Exosomes are small membrane vesicles in a cell culture. They are secreted by most cells and originate from the endosomal pathway. A variety of proteins, lipids, and genetic materials have been shown to be carried by exosomes.

Stem cell-derived extracellular vesicles in the therapeutic intervention of Alzheimer's Disease, Parkinson's Disease, and stroke.

With the increase in the aging population, the occurrence of neurological disorders is rising. Recently, stem cell therapy has garnered attention due to its convenient sourcing, minimal invasiveness, and capacity for directed differentiation. However, there are some disadvantages, such as poor quality control, safety assessments, and ethical and logistical issues.