Exploring the Causal Relationship Between Inflammatory Cytokines and MRI-Derived Brain Iron: A Mendelian Randomization Study.

Background: The association between inflammation and brain iron deposition is widely acknowledged. However, the precise causal impact of peripheral inflammatory cytokines on changes in brain iron content remains uncertain.

Methods: The study utilized an available genome-wide association study (GWAS) summary associated with inflammatory cytokines from The Cardiovascular Risk in Young Finns Study and the FINRISK surveys.

Bidirectional Mendelian randomization explores the causal relationship between dietary habits and rheumatoid arthritis.

Epidemiological and other studies have shown that the occurrence and progression of rheumatoid arthritis (RA) are closely related to diet. To further explore the causal association between dietary habits and RA, we performed a bidirectional Mendelian randomization (MR) analysis. The dataset related to dietary habits is from genome-wide association studies, including 143 dietary habits.

Endoprosthetic replacement with preservation of the epiphysis for proximal tibial reconstruction after osteosarcoma resection in children: a case report.

Background: Limb salvage surgery is an important method for treating malignant tumors of the bone involving the adjacent parts of the major joints in children. This technique allows for preservation of limb function, especially in the lower limb. However, the reconstruction of the proximal end of the tibia after removing the tumor mass with a rational scale to preserve the total knee joint and reduce limb length discrepancy presents a challenge.

Identification of Causing Foliar Blight on in China.

Begonia semperflorens Link et Otto (Begoniaceae) is a flowering, ornamental plant widely cultivated in China. In April of 2020, a foliar blight disease on B. semperflorens was observed in plant nurseries (∼0.