Chronic kidney disease: a contraindication for using biodegradable magnesium or its alloys as potential orthopedic implants?

Magnesium (Mg) has gained widespread recognition as a potential revolutionary orthopedic biomaterial. However, whether the biodegradation of the Mg-based orthopedic implants would pose a risk to patients with chronic kidney disease (CKD) remains undetermined as the kidney is a key organ regulating mineral homeostasis. A rat CKD model was established by a 5/6 subtotal nephrectomy approach, followed by intramedullary implantation of three types of pins: stainless steel, high pure Mg with high corrosion resistance, and the Mg-Sr-Zn alloy with a fast degradation rate.

Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes.

Background: Increasing attention is being paid to the environmental and health impacts of nanoplastics (NPs) pollution. Exposure to nanoplastics (NPs) with different charges and functional groups may have different adverse effects after ingestion by organisms, yet the potential ramifications on mammalian blood glucose levels, and the risk of diabetes remain unexplored.

Results: Mice were exposed to PS-NPs/COOH/NH at a dose of 5 mg/kg/day for nine weeks, either alone or in a T2DM model.

Creation of an Atherosclerosis Model Using Palmitic Acid and Oleic Acid in the Vascular Smooth Muscle Cells of Rats.

Background: Atherosclerosis (AS) is a chronic vascular inflammatory disease resulting from vascular endothelial injury and lipid deposition, closely linked to abnormal lipid metabolism within the body. The critical processes involved in atherosclerosis encompass lipid deposition, oxidation, metabolic disruptions, and inflammatory stimulation within the inner vessel wall. Lipid deposition emerges as a pivotal factor triggering these pathological changes, with vascular smooth muscle cells (VSMCs) playing a significant role in the development of AS.

Comparing the effects and mechanisms of exposure to polystyrene nanoplastics with different functional groups on the male reproductive system.

After aging in the environment, some nanoplastics will carry different charges and functional groups, thereby altering their toxicological effects. To evaluate the potential impact of aging of nanoplastics on the mammalian reproductive system, we exposed C57BL/6 male mice to a dose of 5 mg/kg/d polystyrene nanoparticles (PS-NPs) with different functional groups (unmodified, carboxyl functionalized and amino functionalized) for 45 days for this study. The results suggest that PS-NPs with different functional groups triggered oxidative stress, a decreased in the testis index, disruption of the outer wall of the seminiferous tubules, reduction in the number of spermatogonia cells and sperm counts, and an increased in sperm malformations.

Odor emission rate of a municipal solid waste sanitary landfill during different operation stages before final closure.

This study investigated the odor emission rate from different areas of a municipal solid waste landfill. The surface odor emission rate (SOER) of eight odorous compound groups were determined by flux chamber method. The SOER of working face, seams of daily cover, membrane surface of daily cover, seams of temporary cover, membrane surface of temporary cover, seams of intermediate cover, membrane surface of intermediate cover were 138.

Protective effect of nicorandil against myocardial ischemia/reperfusion injury mediated via IL33/ST2 signaling pathway.

Myocardial ischemia-reperfusion injury (MI/RI), a complication of myocardial injury, is associated with high rates of mortality and disability. We aimed to explore the effect of nicorandil™ against MI/RI and investigated the underlying molecular mechanisms. In this in vitro study, hypoxia/reoxygenation (H/R) processing of H9c2 cells significantly suppressed the expressions of IL33 and ST2, reduced cell viability, increased production of reactive oxygen species, downregulated protein expression of Bcl-2, upregulated protein expressions of Bax, cleaved caspase3, and cleaved PARP, increased intracellular calcium overload, and induced cell apoptosis.

Effect of biochemical composition on odor emission potential of biowaste during aerobic biodegradation.

This study aimed to identify the individual effect of biochemical composition on odor emission potential of biowaste during aerobic biodegradation. Three kinds of typical mixed wastes, including vegetable-fruit waste, garden waste, and protein-rich waste, were tested for emission quantity of seven common odorous families within 21 days of biodegradation under aerobic conditions. The cumulative odor yields (COY) were as follows: protein-rich waste (2408 μg g DM) > vegetable-fruit waste (1169 μg g DM) > garden waste (62 μg g DM), and their cumulative odor intensity were 16,701, 1888, and 212 g DM, respectively.