Seven points as an estimate of the smallest subjectively experienced decrease in body satisfaction on a one-item Visual Analogue Scale.

Visual Analogue Scales (VASs) are very commonly used to measure short-term effects on state body satisfaction, the in-the-moment subjective evaluation of one's own body. However, VASs lack easily understood metrics for comparing and interpreting the size of different effects, with the result that researchers often conclude that any statistically significant change on these 101-point scales is practically important. In addition to test-retest reliability and construct validity, here we estimate the smallest subjectively experienced difference for a one-item body satisfaction VAS.

High cognitive load during attention to images of models reduces young women's social comparisons: Further evidence against cognitive efficiency.

Mental processes that are conducted frequently can become highly cognitively efficient, meaning they can be carried out while we are doing other tasks (i.e., under high cognitive load).

Social comparisons with media images are cognitively inefficient even for women who say they feel pressure from the media.

The present study investigated whether social comparisons with media images are cognitively efficient (demanding minimal mental effort) or cognitively effortful processes, in a sample of female undergraduate students (N=151) who reported feeling pressure from the media regarding their appearance. Two groups were shown 12 images of thin and attractive female models. One group was asked to memorize a complex 8-digit number during exposure to the images (Cognitively Busy condition), while the other memorized a much simpler number (Free View condition).

The role of similarity, sound and awareness in the appreciation of visual artwork via motor simulation.

One way to increase art appreciation is to create congruency between the actions performed by the artist and the actions performed by the viewer. Leder, Bar, and Topolinski (2012) successfully created such a link by asking participants to make either stroking or stippling motions while viewing stroke-style and pointillist-style paintings. We carried out a direct replication of Leder et al.

Highlighting media modifications: can a television commercial mitigate the effects of music videos on female appearance satisfaction?

Exposure to idealized media portrayals of women induces appearance dissatisfaction in females, in the short term. Interventions that highlight the artificial nature of media portrayals can mitigate this effect. The present research investigated whether a 75 second television commercial, that demonstrates behind-the-scenes techniques used to artificially enhance media models, could be similarly effective.

Meta-analytic moderators of experimental exposure to media portrayals of women on female appearance satisfaction: Social comparisons as automatic processes.

Experimental exposure to idealized media portrayals of women is thought to induce social comparisons in female viewers and thereby to be generally detrimental to female viewers' satisfaction with their own appearance. Through meta-analysis, the present paper examines the impact of moderators of this effect, some identified and updated from a prior meta-analysis and some that have hitherto received little attention. Participants' pre-existing appearance concerns and the processing instructions participants were given when exposed to media portrayals were found to significantly moderate effect sizes.

Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial.

Objective: To determine the efficacy of a probiotic drink containing Lactobacillus for the prevention of any diarrhoea associated with antibiotic use and that caused by Clostridium difficile.

Design: Randomised double blind placebo controlled study.

Participants: 135 hospital patients (mean age 74) taking antibiotics.

Development of a time-to-positivity assay as a tool in the antibiotic management of septic patients.

Optimal use of antibiotics is a key component of the management of sepsis. The purpose of this study was to develop a modification of the time-to-positivity (T(pos)) assay for use in the acute management of septic patients. Initial laboratory experiments, followed by ex-vivo validation and pilot studies, were performed with a small number of healthy human volunteers and 46 septic patients on a general intensive care unit, chosen on the basis of their antibiotic regimen.

Siblings and theory of mind in deaf native signing children.

We report a study designed to examine the basis of "theory of mind" (ToM) reasoning in deaf children who are native signers of British Sign Language. The participants were 20 native signers (aged 4-8 years) and their siblings. The children were given a measure of the quality of sibling relations together with a referential communication test concerning physical representations of objects and people.

Antibiotic prophylaxis in surgery of the intervertebral disc. A comparison between gentamicin and cefuroxime.

Antibiotics are often administrated prophylactically in spinal procedures to reduce the risk of infection of the disc space. It is still not known which antibiotics are able to penetrate the intervertebral disc effectively. In a prospective, randomised, double-blind clinical study, we examined the penetration of the intervertebral discs of two commonly used antibiotics, cefuroxime and gentamicin.

Signposts to development: theory of mind in deaf children.

Possession of a "theory of mind" (ToM)--as demonstrated by an understanding of the false beliefs of others--is fundamental in children's cognitive development. A key question for debate concerns the effect of language input on ToM. In this respect, comparisons of deaf native-signing children who are raised by deaf signing parents with deaf late-signing children who are raised by hearing parents provide a critical test.

Severe impairment in grammar does not preclude theory of mind.

Debates about the role of language in human thinking are increasingly prominent in the cognitive sciences. There are claims that certain forms of reasoning can only be performed through access to the resources of the language faculty. In particular, a component of social cognition involving the representation of the mental states of others ('theory of mind' reasoning) has been claimed necessarily to involve propositions of natural language.

Mind over grammar: reasoning in aphasia and development.

Research on propositional reasoning (involving 'theory of mind' understanding) in adult patients with aphasia reveals that reasoning can proceed in the absence of explicit grammatical knowledge. Conversely, evidence from studies with deaf children shows that the presence of such knowledge is not sufficient to account for reasoning. These findings are in keeping with recent research on the development of naming, categorization and imitation, indicating that children's reasoning about objects and actions is guided by inferences about others' communicative intentions.

Learning from other people's mistakes: causal understanding in learning to use a tool.

Despite considerable debate about whether nonhuman primates learn to use tools via imitation, this type of learning by children has received surprisingly little attention. The findings of two studies that go some way toward filling this gap are reported here. Study 1 showed that when 2- and 3-year-old children (N = 68) were shown a correct solution to a tool-using task (which they could not solve spontaneously), all the children in both age groups managed at least a partial solution.

A new in-vitro model to investigate antibiotic penetration of the intervertebral disc.

We have studied the ability of a range of antibiotics to penetrate intervertebral disc tissue in vitro, using a mouse disc model. Equilibrium concentrations of antibiotics incorporated into the entire disc were determined by bioassay using a microbial growth-inhibition method. Uptake was significantly higher with positively-charged aminoglycosides compared with negatively-charged penicillins and cephalosporins.

Assay of vancomycin by fluorescence polarisation immunoassay and EMIT in patients with renal failure.

Serum with vancomycin concentrations between 5 and 15 mg/L from patients on dialysis were assayed by fluorescence polarization immunoassay (FPIA) and enzyme multiplied immunoassay technique (EMIT). The concentrations as determined by FPIA were higher than those using EMIT (mean difference 2.1 mg/L, S.

An outbreak of Enterobacter cloacae associated with contamination of a blood gas machine.

Over a 3-month period, five cases of Enterobacter cloacae bacteraemia occurred on our neonatal unit. In at least three of these, isolation of the organism coincided with clinical deterioration and evidence of sepsis. In one case, the same strain was isolated from an abscess on the neonate's forearm.

Characterisation of strains of Aeromonas spp. by phenotype and whole-cell protein fingerprint.

Sixty-eight isolates of Aeromonas spp. were examined biochemically and their cell proteins were analysed by silver-stained SDS-PAGE. Protein fingerprints did not correlate with phenotype.

An epidemiological study of listeriosis complicating a bone marrow transplant.

Following an unrelated-donor bone marrow transplant a six-year-old child with severe aplastic anaemia developed Listeria monocytogenes septicaemia and meningitis. Cook-chill foods consumed during his stay in hospital were found to contain strains of L. monocytogenes and other Listeria species.

Whole-cell protein electrophoresis for typing Mycobacterium tuberculosis.

A method of discriminating between strains of Mycobacterium tuberculosis by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell proteins combined with a sensitive silver stain is described. Thirty-five isolates of M. tuberculosis and five isolates from other species of Mycobacterium were examined, including serial isolates from the same patients and isolates from a small cluster of hospital cases.

Pseudomonas pickettii infections in a paediatric oncology unit.

Over a 3-month period, seven patients in a paediatric oncology unit developed Pseudomonas pickettii septicaemias. The outbreak was difficult to recognize since the cases occurred at widely spaced intervals and problems were experienced with the identification of the isolates. Many of the isolates were initially misidentified on the basis of a short sugar set used in the laboratory for identification of the non-fermenting Gram-negative bacilli.

Effects of incorporating ampicillin, bile salts and carbohydrates in media on the recognition and selection of Aeromonas spp. from faeces.

The effects of incorporating ampicillin, some bile salts and sugars into media on the primary recognition and selection of aeromonads from faeces were examined. Most (88%) of the 101 Aeromonas strains examined had an ampicillin MIC of greater than or equal to 40 mg/L, and would be isolated on blood agar containing ampicillin 30 mg/L. The strains with an ampicillin MIC of less than 40 mg/L were all of human origin and predominantly A.

A prospective, randomized comparison of ceftazidime and ciprofloxacin as initial empiric therapy in neutropenic patients with fever.

This study developed further clinical experience in using a single agent ("monotherapy") as empirical treatment for neutropenic patients with fever, and compared the safety and toxicity of two candidate agents, ceftazidime and ciprofloxacin. A prospective, randomized, single-center efficacy and safety comparison was conducted of intravenous ciprofloxacin, 200 mg every 12 hours, and ceftazidime, 2 g every eight hours, as initial empirical therapy in neutropenic patients with fever. Regimens were modified as necessary, guided by laboratory results and/or the clinical condition.

Typing of Aeromonas species by protein fingerprinting: comparison of radiolabelling and silver staining for visualising proteins.

A method for typing Aeromonas species by silver staining of total soluble proteins separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis is described. There was good agreement with the results obtained by autoradiography of whole-cell proteins for isolates examined by both methods.