Publications by authors named "Wanshuang Luo"
Article Synopsis
- N-myc and STAT interactor (NMI) is a protein that is induced by interferons and helps regulate antiviral responses in various species, but its role in ducks during Duck Tembusu Virus (DTMUV) infection is still unknown.
- Researchers cloned the duck NMI gene (duNMI), which consists of 1,137 base pairs coding for 378 amino acids and found that it has the highest expression in the harderian gland, small intestine, and pancreas of 7-day-old ducks.
- Upon DTMUV infection, duNMI expression increases, inhibiting viral replication and affecting the transcription of interferon-related cytokines, indicating its role as an inhibitor of antiviral immune response in ducks during D
Vet Microbiol
November 2023
Article Synopsis
- TRAF3 is an important signaling molecule in the immune response, studied primarily in mammals, but its role in ducks is less understood.
- Researchers cloned and sequenced the mallard duck's TRAF3 (duTRAF3), discovering it shares similar functions with its mammalian counterpart and is primarily expressed in the harderian gland, heart, and lung.
- The study found that duck Tembusu virus (DTMUV) increases duTRAF3 levels, which then helps inhibit the virus's replication and activates immune response genes, although DTMUV's NS protein 5 can suppress duTRAF3's function, highlighting duTRAF3's potential as an antiviral target.
