Publications by authors named "Wanrun Xie"
Background: Given the growing acknowledgment of the detrimental effects of excessive myocardial fibrosis on pathological remodeling after myocardial ischemia-reperfusion injury (I/R), targeting the modulation of myocardial fibrosis may offer protective and therapeutic advantages. However, effective clinical interventions and therapies that target myocardial fibrosis remain limited. As a promising chimeric antigen receptor (CAR) cell therapy, whether CAR macrophages (CAR-Ms) can be used to treat I/R remains unclear.
View Article and Find Full Text PDFCausal association of circulating metabolites with diabetic retinopathy: a bidirectional Mendelian randomization analysis.
Front Endocrinol (Lausanne)
May 2024
Introduction: The retina is a highly metabolically active tissue, and there is a lack of clarity about the relationship between metabolites and diabetic retinopathy (DR). This study used two-sample bidirectional Mendelian randomization (MR) analyses to identify causal relationships between metabolites and DR.
Methods: Genetic variants were selected from the open-access Genome-Wide Association Studies (GWAS) summary database as proxies for the 1400 most recently published metabolites.
Background: Acute myocardial infarction (AMI) and diabetic nephropathy (DN) are common clinical co-morbidities, but they are challenging to manage and have poor prognoses. There is no research on the bioinformatics mechanisms of comorbidity, and this study aims to investigate such mechanisms.
Methods: We downloaded the AMI data (GSE66360) and DN datasets (GSE30528 and GSE30529) from the Gene Expression Omnibus (GEO) platform.
Article Synopsis
- This systematic review and meta-analysis evaluated the effects of glucagon-like peptide 1 receptor agonists (GLP-1RAs) on different types of body fat in people with diabetes or non-alcoholic fatty liver disease.
- The analysis included 13 randomized controlled trials and found that GLP-1RAs significantly reduced visceral and subcutaneous fat, body weight, and BMI, while also improving blood sugar control and insulin resistance.
- Overall, the study supports the use of GLP-1RAs as effective treatments for reducing fat accumulation and improving metabolic health in individuals with diabetes and obesity-related conditions.
Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological malignancies. Macrophages have also gained attention as an immunotherapy owing to their immunomodulatory capacity and ability to infiltrate solid tumors and phagocytize tumor cells. The first-generation CD3ζ-based CAR-macrophages could phagocytose tumor cells in an antigen-dependent manner.
View Article and Find Full Text PDFDiabetic nephropathy (DN) is a widespread diabetic complication and a major cause of terminal kidney disease. There is no doubt that DN is a chronic disease that imposes substantial health and economic burdens on the world's populations. By now, several important and exciting advances have been made in research on etiopathogenesis.
View Article and Find Full Text PDFBackground: Acarbose and repaglinide are widely used either by themselves or in combination with other medications. However, their efficacy in diabetes control has not been compared when used in combination with metformin.
Methods: The present study aimed to compare their effects on glycemic variability (GV) control when taken with metformin for type 2 diabetes mellitus (T2DM) inadequately controlled with metformin alone.