The role of methylprednisolone in severe COVID-19 patients: a meta-analysis.

Background: The purpose of this study is to assess the effectiveness of methylprednisolone in severe COVID-19.

Methods: PubMed, the Cochrane Library and Web of Science were searched for literatures comparing methylprednisolone and control treatment in severe COVID-19 patients. Statistical pooling was reported as risk ratio (RR) with corresponding 95% confidence interval (CI).

The Zoige pioneer plant has different endophytic bacterial community structures to adapt to environmental conditions.

Background: is a pioneer plant grown in the Zoige desertified alpine grassland and it is also one of the dominant plant species used for environmental remediation. plays a large role in vegetation reconstruction in sandy land, but the abundance and diversity of its endophytes have not yet been investigated.

Objectives: This study was performed to investigate the changes in the endophytic bacterial community structure of under different ecological environments and to analyze the effects of environmental changes and different plant tissues on the endophytic bacteria.

CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding A Novel TMEFF1-339aa Protein.

Skeletal muscle atrophy is a common clinical feature of many acute and chronic conditions. Circular RNAs (circRNAs) are covalently closed RNA transcripts that are involved in various physiological and pathological processes, but their role in muscle atrophy remains unknown. Global circRNA expression profiling indicated that circRNAs are involved in the pathophysiological processes of muscle atrophy.

[Medication law and mechanism of traditional Chinese medicine in prevention and treatment of epidemic diseases: based on traditional Chinese medicine theory of cold pestilence].

Epidemic diseases have caused huge harm to the society. Traditional Chinese medicine(TCM) has made great contributions to the prevention and treatment of them. It is of great reference value for fighting diseases and developing drugs to explore the medication law and mechanism of TCM under TCM theory.

Differential Refinement Network for Zero-Shot Learning.

Zero-shot learning (ZSL) aims to recognize novel categories by merely utilizing disjoint seen samples. It is a challenging task as the knowledge of unseen objects is forbidden in the training stage, which easily leads to unseen samples degrading to mismatched categories. In order to alleviate the biased recognition problem, in this article, we propose a differential refinement network (DRNet) for ZSL, which aims to explore robust semantic-to-visual embedding.

Delivery of engineered extracellular vesicles with miR-29b editing system for muscle atrophy therapy.

Muscle atrophy is a frequently observed complication, characterized by the loss of muscle mass and strength, which diminishes the quality of life and survival. No effective therapy except exercise is currently available. In our previous study, repressing miR-29b has been shown to reduce muscle atrophy.

Targeting miR-30d reverses pathological cardiac hypertrophy.

Background: Pathological cardiac hypertrophy occurs in response to numerous stimuli and precedes heart failure (HF). Therapies that ameliorate pathological cardiac hypertrophy are highly needed.

Methods: The expression level of miR-30d was analyzed in hypertrophy models and serum of patients with chronic heart failure by qRT-PCR.

The first complete mitochondrial genome of the genus , represented by Hsueh, 2019 (Annelida, Nereididae) from Beibu Gluf, China.

The genus Peters, 1854 is characterized in the polychaete family Nereididae by its feather-shaped branchiae on the anterior segments. In this study, we present the first complete mitogenome of , represented by . Hsueh, 2019, collected from Beibu Gulf, China.

Knockdown of long non-coding RNA SOX21-AS1 attenuates amyloid-β-induced neuronal damage by sponging miR-107.

Background: Alzheimer's disease (AD), which has no effective drugs to delay or prevent its progression, is a multifactorial complex neurodegenerative disease. Long non-coding RNA SOX21 antisense RNA1 (SOX21-AS1) is associated with the development of AD, but the underlying molecular mechanism of SOX21-AS1 in AD is still largely unclear.

Methods: To construct the AD model, SH-SY5Y and SK-N-SH cells were treated with amyloid-β1-42 (Aβ1-42).

Deep reinforcement learning for weak human activity localization.

Human activity localization aims at recognizing contents and detecting locations of activities in video sequences. With an increasing number of untrimmed video data, traditional activity localization methods always suffer from two major limitations. First, detailed annotations are needed in most existing methods, i.

[The exploration of the academic thought of external treatment master-Wu ShiJi].

To explore Wu Shiji's academic thought, his external treatment method were arranged and summarized, such as treatment based on triple energizer differentiation, the theory of plaster heals various disease and the combination of the application of acupuncture, moxibustion and plaster etc. It has been proved that Wu's external treatment had compiled all the advantages of each school of Chinese medicine before his era, rich in content and convenient to use. So it values highly in clinical practice and has provided great convenience for the modern clinical research of external treatment.