Bladder cancer immune-related markers: diagnosis, surveillance, and prognosis.

As an immune-related tumor type, bladder cancer has been attracting much attention in the study of its markers. In recent years, researchers have made rapid progress in the study of immune-related markers for bladder cancer. Studies have shown that immune-related markers play an important role in the diagnosis, prognosis assessment and treatment of bladder cancer.

Validation of hyperthermia as an enhancer of chemotherapeutic efficacy: insights from a bladder cancer organoid model.

Objective: This study aimed to evaluate the combined efficacy of hyperthermia and chemotherapy using a bladder cancer organoid model and to explore hyperthermia-related molecular pathways.

Method: Tumor organoids were generated by embedding RT4 bladder cancer cells into Matrigel. The resulting organoids were treated with pirarubicin or gemcitabine at 37 °C or 42 °C.

In Situ Fabrication of Silver Peroxide Hybrid Ultrathin Co-Based Metal-Organic Frameworks for Enhanced Chemodynamic Antibacterial Therapy.

Bacterial-induced infectious diseases have always caused an unavoidable problem and lead to an increasing threat to human health. Hence, there is an urgent need for effective antibacterial strategies to treat infectious diseases. Current methods are often ineffective and require large amounts of hydrogen peroxide (HO), with harmful effects on normal healthy tissue.

Unveiling the retrogradation mechanism of a novel high amylose content starch- seed.

The research of starch retrogradation have been attracting interest. Thereby, the long-term retrogradation mechanism (0-21 days) of seed starch (PCSS) was investigated. The results showed that crystal type was changed from A- to B + V-type during retrogradation.

A multifunctional nanocatalytic system based on Chemodynamic-Starvation therapies with enhanced efficacy of cancer treatment.

A multi-functional nanocatalytic system based on combined therapies has attracted considerable research attention in recent years due to its potential in the treatment of cancer. Herein, ZnO@Au@ZIF-67 nanoparticles (NPs) based on hydroxyl radical (•OH) mediated chemodynamic therapy (CDT) and glucose-exhausting starvation therapy (ST) were constructed. Specifically, in the acidic tumor microenvironment (TME), the pH responsive decomposition of the shell ZIF-67 triggered the release of the Fenton-like catalyst Co, after which the exposed zinc peroxide (ZnO) reacted with HO (H) to generate O and hydrogen peroxide (HO).

Effect of new type extrusion modification technology on supramolecular structure and glycemic release characteristics of starches with various estimated glycemic indices.

Nowadays, the highly effective modified technology to starch with various digestibility is gaining interest in food science. Here, the interactions between glycemic release characteristics and fine supramolecular structure of cassava (ECS), potato (EPS), jackfruit seed (EJFSS), maize (EMS), wheat (EWS), and rice starches (ERS) prepared with improved extrusion modification technology (IEMS) were investigated. The crystalline structures of all extruded cooking starches changed from the A-type to V-type.