Improved lung cancer classification by employing diverse molecular features of microRNAs.

MiRNAs are edited or modified in multiple ways during their biogenesis pathways. It was reported that miRNA editing was deregulated in tumors, suggesting the potential value of miRNA editing in cancer classification. Here we extracted three types of miRNA features from 395 LUAD and control samples, including the abundances of original miRNAs, the abundances of edited miRNAs, and the editing levels of miRNA editing sites.

Phased secondary small interfering RNAs in var. .

Phased secondary small interfering RNAs (phasiRNAs) in plants play important roles in regulating genome stability, plant development and stress adaption. var. has immense economic, medicinal and cultural significance.

Identification of microRNA editing sites in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is a malignant tumor originating from the renal tubular epithelium. Although the microRNAs (miRNAs) transcriptome of ccRCC has been extensively studied, the role of miRNAs editing in ccRCC is largely unknown. By analyzing small RNA sequencing profiles of renal tissues of 154 ccRCC patients and 22 normal controls, we identified 1025 miRNA editing sites from 246 pre-miRNAs.

MicroRNAs in Extracellular Vesicles of Alzheimer's Disease.

Alzheimer's disease (AD) is a neurodegenerative disease with dysfunction of memory, language and thinking. More than 55 million people were diagnosed with AD or other dementia around the world in 2020. The pathology of AD is still unclear and there are no applicable therapies for AD.

Case report: A heterozygous mutation in leads to growth hormone deficiency.

Weiss-Kruszka syndrome (WSKA) is a rare disease most often caused by mutations in the gene. To screen for hereditary diseases, exons from the patient's genome were sequenced. Genomic PCR experiments followed by Sanger sequencing were used to confirm the mutated genomic regions in the patient and his parents.

Identification of microRNA editing sites in three subtypes of leukemia.

Leukemia is an aberrant hyper-proliferation of immature blood cells that do not form solid tumors. The transcriptomes of microRNAs (miRNAs) of leukemia have been intensively explored. However, miRNA editing of leukemia has not been extensively studied.

Modelling the octanol-air partition coefficient of aromatic pollutants based on the solvation free energy and the dimer effect.

In this study, generalized predictive models were developed to estimate K of four kinds of aromatic pollutants based on the calculated solvation free energy and taking the dimer effect into account. Uncorrected log K values, which were directly estimated from the calculated solvation free energy of individual molecules, underestimated experimental values, and the deviation increased with increasing log K. Dimers were found to greatly affect the apparent K values of these aromatic pollutants, which were driven by π-π interactions.

MicroRNA editing patterns in Huntington's disease.

Huntington's disease (HD) is a neurodegenerative disease. MicroRNAs (miRNAs) are small non-coding RNAs that mediate post-transcriptional regulation of target genes. Although miRNAs are extensively edited in human brains, the editome of miRNAs in brains of HD patients is largely unknown.

Sorptive removal of methylene blue from water by magnetic multi-walled carbon nanotube composites.

In the present study, five magnetic multi-walled carbon nanotubes (MMWCNTs) with different diameters were prepared and their performance on the sorptive removal of methylene blue (MB) from water was investigated. Transmission electron microscope, scanning electron microscope, Fourier transform infrared spectrometer, X-ray diffraction, and vibrating sample magnetometer confirm that the surface of these MMWCNTs has been decorated by FeO nanoparticles, which renders the MMWCNTs superparamagnetic. Thus, these MMWCNTs can be easily separated from water after the adsorption.

Recent Progress on Relevant microRNAs in Autism Spectrum Disorders.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases.

Generation and properties of aqu/nC: the combined effects of humic acid, sunlight, and agitation intensity.

Once released into natural water, the environmental behavior and fate of C could inevitably been affected by humic acid (HA), sunlight, and hydrodynamic conditions. However, the combined effects of these factors are not so clear. Therefore, in the present study, effects of HA, sunlight, and agitation intensity on generation and properties of aqu/nC were investigated.

Prediction of octanol-air partition coefficients for PCBs at different ambient temperatures based on the solvation free energy and the dimer ratio.

Temperature-dependent octanol-air partition coefficients (K) are of great importance in assessing the environmental behavior and fate of persistent organic pollutants including polychlorinated biphenyls (PCBs). Due to the tremendous amounts of time, effort and cost needed for the experimental determination of K, it is desirable to develop a rapid and precise predictive method to estimate K just based on molecular structure. In the present study, a predictive model for log K of PCBs at ambient temperatures was developed based on the thermodynamic relationship between K and the solvation free energy from air to octanol (ΔG).