Prevalence of internet gaming disorder among Chinese adolescents: A systematic review and meta-analysis.

This study aimed to evaluate the prevalence of IGD among Chinese adolescents. Articles published up to April 11, 2024 were retrieved from PubMed, Wiley Online Library, Embase, Web of Science, Ebsco, CNKI, and WanFang. Random-effects models and univariate meta-regression analyses were used to calculate prevalence and heterogeneity estimates with the support of Stata17.

Structural Insights into the Dynamic Assembly of a YFV sNS1 Tetramer.

Yellow fever virus (YFV) infections can cause severe diseases in humans, resulting in mass casualties in Africa and the Americas each year. Secretory NS1 (sNS1) is thought to be used as a diagnostic marker of flavivirus infections, playing an essential role in the flavivirus life cycle, but little is known about the composition and structure of YFV sNS1. Here, we present that the recombinant YFV sNS1 exists in a heterogeneous mixture of oligomerizations, predominantly in the tetrameric form.

Mechanism of the wine pomace tannin in hyperpigmentation inhibition: Impact on signaling pathways, cell proliferation, and tyrosinase activity.

After winemaking, tannins with high polymerization remain in the pomace. Utilizing these tannin fractions is a concern for the wine industry. While tannins show potential in treating hyperpigmentation, their mechanisms in vivo and at the cellular level are unclear.

Enhanced lactic acid production through enzymatic hydrolysis: Assessing impact of varied enzyme loadings on co-fermentation of swine manure and apple waste.

Anaerobic co-fermentation of swine manure (SM) and apple waste (AW) restricts by the slow hydrolysis of substrates with complex structures, which subsequently leads to low lactic acid (LA) production. Therefore, a novel strategy based on enzymatic pretreatment for improving LA production from anaerobic co-fermentation of SM and AW was proposed in this study. The results indicated that the maximal LA concentration increased from 35.

Lactic acid production with two types of feedstocks from food waste: Effect of inoculum, temperature, micro-oxygen, and initial pH.

Lactic acid (LA) is an important chemical with broad market applications. To optimize LA production, food waste has been explored as feedstock. Due to the wide variety of food waste types, most current research studies have obtained different conclusions.

The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution.

Flaviviruses encode a conserved, membrane-associated nonstructural protein 1 (NS1) with replication and immune evasion functions. The current knowledge of secreted NS1 (sNS1) oligomers is based on several low-resolution structures, thus hindering the development of drugs and vaccines against flaviviruses. Here, we revealed that recombinant sNS1 from flaviviruses exists in a dynamic equilibrium of dimer-tetramer-hexamer states.

Enzyme enhanced lactic acid fermentation of swine manure and apple waste: Insights from organic matter transformation and functional bacteria.

Anaerobic co-fermentation is a favorable way to convert agricultural waste, such as swine manure (SM) and apple waste (AW), into lactic acid (LA) through microbial action. However, the limited hydrolysis of organic matter remains a main challenge in the anaerobic co-fermentation process. Therefore, this work aims to deeply understand the impact of cellulase (C) and protease (P) ratios on LA production during the anaerobic co-fermentation of SM with AW.

A High-Performance Food Package Material Prepared by the Synergistic Crosslinking of Gelatin with Polyphenol-Titanium Complexes.

This study aims to enhance gelatin film performance in the food industry by incorporating polyphenol-titanium complexes (PTCs) as crosslinkers. PTCs introduce multiple linkages with gelatin, including coordination and hydrogen bonds, resulting in synergistic crosslinking effects. This leads to an increased hydrodynamic volume, particle size, and thermal stability of the gelatin films.

Microbial composition play the leading role in volatile fatty acid production in the fermentation of different scale of corn stover with rumen fluid.

Rumen fluid is a natural and green biocatalyst that can efficiently degrade biomass into volatile fatty acid (VFA) used to produce value-added materials. But the essence of high degradation efficiency in the rumen has not been fully analyzed. This study investigated the contribution of substrate structure and microbial composition to volatile fatty acid production in the fermentation of corn stover.

Transferrin receptor 1 promotes hepatocellular carcinoma progression and metastasis by activating the mTOR signaling pathway.

Background: Aberrant iron metabolism is commonly observed in multiple tumor types, including hepatocellular carcinoma (HCC). However, as the key regulator of iron metabolism involved in iron absorption, the role of transferrin receptor (TFRC) in HCC remains elusive.

Methods: The mRNA and protein expression of TFRC were evaluated in paired HCC and adjacent non-tumor specimens.

Responses of CH, NO, and NH emissions to different slurry pH values of 5.5-10.0: Characteristics and mechanisms.

Animal slurry storage is a significant source of greenhouse gas (GHG) and ammonia (NH) emissions. pH is a basic but key factor that could pose great influence on gas emissions, but the simultaneous evaluation of its influence on GHG and NH emissions and the understanding of its underlying mechanism are not enough. In this work, pH was adjusted between 5.

Effects of self-produced lactic fermentation (SPLF) on GHG and VSC emissions during swine slurry storage.

Self-produced lactic fermentation (SPLF) is a new valued utilization technology, but its impact on gas emission remains unclear. The objective of this study is to investigate the effect of replacing the HSO additive with SPLF on greenhouse gas (GHG), and volatile sulfur compound (VSC) emissions from swine slurry storage in a laboratory-scale study. In this study, SPLF is directed toward producing lactic acid (LA) through the anaerobic fermentation of slurry and apple waste under the most suitable conditions, with the LA concentration kept at 10,000-52000 mg COD/L and the pH remaining within 4.

Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response.

Gut dysbiosis has been reported in chronic hepatitis B (CHB) infection, however its role in CHB progression and antiviral treatment remains to be clarified. Herein, the present study aimed to characterize gut microbiota (GM) in patients with chronic hepatitis B virus infection-associated liver diseases (HBV-CLD) by combining microbiome with metabolome analyses and to evaluate their effects on peripheral immunity. Fecal samples from HBV-CLD patients (n = 64) and healthy controls (n = 17) were collected for 16s rRNA sequencing.

The chemical components, action mechanisms, and clinical evidences of YiQiFuMai injection in the treatment of heart failure.

YiQiFuMai injection (YQFM), derived from Shengmai Powder, is wildly applied in the treatment of cardiovascular diseases, such as coronary heart disease and chronic cardiac insufficiency. YiQiFuMai injection is mainly composed of Radix of C.A.

Revealing mechanism of micro-aeration for enhancing volatile fatty acids production from swine manure.

Micro-aeration is considered a new strategy for improving volatile fatty acids (VFAs) production of agricultural waste. This study investigated the effect and mechanism of micro-aeration of air and oxygen (O) on VFAs production from swine manure. The results showed that Air-micro-aeration had the most significant improvement effect, with the highest VFAs of 8.

Direct Purification of Digestate Using Polymeric Ultrafiltration Membranes: Influence of Materials on Filtration Behavior and Fouling Characteristics.

In-depth exploration of filtration behavior and fouling characteristics of polymeric ultrafiltration (UF) membranes can provide guidance for the selection of materials and the control of membrane fouling during the purification of digestate. In this study, four types of polymeric membranes, (polyethersulfone (PES), polysulfone (PS), polyvinylidene fluoride (PVDF), and polyacrylonitrile (PAN)), were employed to filter digestate from swine manure. The results showed that the viscosity of the digestate dropped from 45.

Antibiotic removal potential for low greenhouse gas emission process of anaerobic digestion (AD) producing volatile fatty acids (VFAs).

This study aimed to investigate the antibiotic of sulfachloropyridazine (SCP) reduction and its effects on volatile fatty acids (VFAs) accumulation and microbial community structures during the process of anaerobic digestion (AD) producing VFA. Results showed that initial SCP concentrations have a positive correlation with reduction of SCP and accumulation of VFAs. The removal rates of SCP were 22.

NLRP3 Inflammasome: a Novel Insight into Heart Failure.

Among numerous cardiovascular diseases, heart failure is a final and fatal stage, and its morbidity, mortality, and rehospitalization rate remain high, which reduces the exercise tolerance of patients and brings great medical burden and economic pressure to the society. Inflammation takes on a major influence in the occurrence, development, and prognosis of heart failure (HF). The NLRP3 inflammasome is a key node in a chronic inflammatory response, which can accelerate the production of pro-inflammatory cytokines IL-1β and IL-18, leading to the inflammatory response.

Improving production of lactic acid and volatile fatty acids from dairy cattle manure and corn straw silage: Effects of mixing ratios and temperature.

Anaerobic co-fermentation (AcoF) of dairy cattle manure (DCM) and corn straw silage (CSS) for producing lactic acid (LA) and volatile fatty acids (VFAs) was investigated. Batch experiments were conducted at seven different DCM/CSS ratios and at mesophilic and thermophilic temperatures. Results indicated that the highest concentration of LA was 17.

Produce individual medium chain carboxylic acids (MCCA) from swine manure: Performance evaluation and economic analysis.

Environmental issues caused by untreated animal manure require the development of resource recovery from waste through a circular economy approach. Producing medium chain carboxylic acids (MCCA) with higher value than biogas from manure has become promising. The objective of this study was to develop an effective individual MCCA produce process utilizing manure.

QiShenYiQi pill for myocardial collagen metabolism and apoptosis in rats of autoimmune cardiomyopathy.

Context: QiShenYiQi pill (QSYQ) is a traditional Chinese medicine with a myocardial protective effect.

Objective: To explore the effect of QSYQ on myocardial collagen metabolism in rats with autoimmune cardiomyopathy and explore the underlying mechanism from the aspect of apoptosis.

Materials And Methods: We established an autoimmune cardiomyopathy model using Lewis rats.

Shengmai San for Treatment of Cardiotoxicity from Anthracyclines: A Systematic Review and Meta-Analysis.

Objective: To systematically evaluate the efficacy of Shengmai San in patients with cardiotoxicity of anthracyclines.

Methods: Randomized controlled trials (RCTs) were identified by searching China National Knowledge Infrastructure (CNKI), Wanfang Database, Chinese Biomedical Literature Database (CBM), PubMed, Cochrane Library, and Embase Databases from the inceptions until December 2020. The Cochrane Handbook was used to evaluate the risk of bias in the included studies.

Lipid Droplet-a New Target in Ischemic Heart Disease.

Lipid droplet (LD) is a kind of subcellular organelle, which originates from the endoplasmic reticulum (ER). LDs can move flexibly between other organelles and store energy in the cells. In recent years, LDs and lipid droplet-associated proteins have attracted added attention at home and abroad, especially in cardiovascular diseases.

Roles of micro-aeration on enhancing volatile fatty acids and lactic acid production from agricultural wastes.

Micro-aeration was proven to be an environmentally friendly strategy for efficiently enhancing volatile fatty acids (VFAs) and lactic acid (LA) production. The roles of micro-aeration on mono-digestion of swine manure (SM) for VFAs production and co-digestion of SM with corn silage (CS) for LA production were investigated, respectively. In this study, micro-aeration increased the maximum VFAs concentration by 20.

Trimethylamine oxide: a potential target for heart failure therapy.

Heart failure (HF) is a clinical syndrome in the late stage of cardiovascular disease and is associated with high prevalence, mortality and rehospitalisation rate. The pathophysiological mechanisms of HF have experienced the initial 'water-sodium retention' mode to 'abnormal hemodynamics' mode, and subsequent to 'abnormal activation of neuroendocrine' mode, which has extensively promoted the reform of HF treatment and updated the treatment concept. Since the Human Microbiome Project commencement, the study on intestinal microecology has swiftly developed, providing a new direction to reveal the occurrence of diseases and the mechanisms behind drug effects.