Ligand-to-Copper Charge-Transfer-Enabled C-H Sulfoximination of Arenes.

Herein, we report a photoinduced sulfoximine-to-copper charge-transfer-enabled generation of sulfoximinyl radicals directly from -sulfoximines for C-H sulfoximination of arenes via radical addition. Through copper-LMCT, N-arylation of -sulfoximines was achieved for the first time using arenes of different electronic structures as the aryl donors.

Decarboxylative sulfoximination of benzoic acids enabled by photoinduced ligand-to-copper charge transfer.

Sulfoximines are synthetically important scaffolds and serve important roles in drug discovery. Currently, there is no solution to decarboxylative sulfoximination of benzoic acids; although thoroughly investigated, limited substrate scope and harsh reaction conditions still hold back traditional thermal aromatic decarboxylative functionalization. Herein, we realize the first decarboxylative sulfoximination of benzoic acids photo-induced ligand to copper charge transfer (copper-LMCT)-enabled decarboxylative carbometalation.

Decarboxylative Hydroxylation of Benzoic Acids.

Herein, we report the first decarboxylative hydroxylation to synthesize phenols from benzoic acids at 35 °C via photoinduced ligand-to-metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation. The aromatic decarboxylative hydroxylation is synthetically promising due to its mild conditions, broad substrate scope, and late-stage applications.

Encapsulated DNase improving the killing efficiency of antibiotics in staphylococcal biofilms.

We developed a polymer-encapsulated DNase, n(DNase), which can efficiently accumulate in biofilm and expose the DNase to cleave the eDNA of the biofilm. CLSM and crystal violet staining results demonstrated effective biofilm disintegration (92.2%) when treated with n(DNase).

Site-Selective C-H Oxygenation via Aryl Sulfonium Salts.

Herein, we report a two-step process forming arene C-O bonds in excellent site-selectivity at a late-stage. The C-O bond formation is achieved by selective introduction of a thianthrenium group, which is then converted into C-O bonds using photoredox chemistry. Electron-rich, -poor and -neutral arenes as well as complex drug-like small molecules are successfully transformed into both phenols and various ethers.