Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy.

Background: Diabetic encephalopathy (DE) is one of the most serious complications of diabetes mellitus (DM), and its pathogenesis has not yet been clarified. Th22 cells are a newly discovered class of CD4 T cells that play important roles in inflammatory, autoimmune and infectious diseases. However, it is unclear whether Th22 cells are involved in the pathogenesis of DE.

Association between the recommended volume of leisure-time physical activity and erectile dysfunction: A cross-sectional analysis of the national health and nutrition examination survey, 2001-2004.

Objective: Physical activity-related interventions alleviate the severity of erectile dysfunction (ED), but it is unknown whether the recommended volume of physical activity (PA) or a higher level of physical activity reduces the likelihood of ED in adult males. We aimed to evaluate the association between the recommended volume of PA and ED among US male adults.

Design: A nationally representative cross-sectional survey.

Targeted Metabolomics Provide Chemotaxonomic Insights of , with Coupled Transcriptomics Elucidating the Mechanism Underlying Floral Coloration.

, a wild legume forage widely distributed in the Eurasian steppe, demonstrates high genetic and phenotypic variation. with a purely yellow flower (YFM), differing from the general phenotype of with a purple flower (PFM), was recently discovered. The similar characteristics of YFM with have led to conflicting opinions on its taxonomy using traditional morphological methods.

Efficient Photothermal Elimination of Formaldehyde under Visible Light at Room Temperature by a MnO-Modified Multi-Porous Carbon Sphere.

Volatile organic compounds (VOCs) exert a serious impact on the environment and human health. The development of new technologies for the elimination of VOCs, especially those from non-industrial emission sources, such as indoor air pollution and other low-concentration VOCs exhaust gases, is essential for improving environmental quality and human health. In this study, a monolithic photothermocatalyst was prepared by stabilizing manganese oxide on multi-porous carbon spheres to facilitate the elimination of formaldehyde (HCHO).

Effect of Hepatitis B Virus Infection on Sperm Quality and Outcomes of Assisted Reproductive Techniques in Infertile Males.

Hepatitis B virus (HBV) infection is one of the health problems and has adverse effects on public health. However, the consequences of male HBV carriers for assisted reproductive techniques (ART) remain unclear. To examine whether men with HBV would impact sperm quality and the intrauterine insemination (IUI)/ fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) outcomes.

Optimizing magnetic functionalization conditions for efficient preparation of magnetic biochar and adsorption of Pb(II) from aqueous solution.

Recoverable magnetic biochar has great potential for treating wastewater contaminants such as Pb(II). However, whether magnetic modification could enhance metal adsorption efficiency is currently contradictory in the literature mainly due to the differences in selecting various magnetic functionalization conditions. Considering this gap in knowledge, the effects of magnetic functionalization method (impregnation and precipitation), concentration of precursor iron solution (0.

CircLMTK2 acts as a tumor suppressor in prostate cancer via regulating the expression of microRNA-183.

Background: Prostate cancer (PCa) is one of the commonest male urinary and reproductive system malignancies with high morbidity and mortality. circLMTK2 was reported as a tumor suppressor, therefore, we attempted to investigate the potential mechanism of circLMTK2 in PCa.

Methods: qRT-PCR was employed to examine the expressions of circLMTK2 and miR-183.

Silencing circular RNA circZNF609 restrains growth, migration and invasion by up-regulating microRNA-186-5p in prostate cancer.

Prostate cancer (PC) fearfully impacts men's health. We explored the efficacy and mechanism of circular RNA circZNF609 (circZNF609) on colony formation, viability, apoptosis, migration and invasion and in PC cells. Colony formation, CCK-8, flow cytometry, migration and invasion assay were respectively used to detect the functions of circZNF609 and microRNA (miR)-186-5p on cell colony ability, viability, apoptosis, migration and invasion.

Environmentally friendly synthesis of photoluminescent biochar dots from waste soy residues for rapid monitoring of potentially toxic elements.

Single-step environmentally friendly synthesis of biochar dots (BCDs) was developed using hydrothermal treatment of waste biomass. Using soy residue as the carbon precursor, the resultant BCDs had strong and stable photoluminescence. Characterization by atomic force microscopy (AFM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and infrared spectroscopy indicates that the BCDs prepared were water soluble, spherical, oxygenous and nitrogen-doped carbon nanoparticles with 10-20 nm in diameter.

Qualitative research on infertile Chinese couples' understanding of sexuality.

Background: Family physicians play an important role in the initial counselling and evaluation of infertility. Despite infertility regarded as a stressor and a life crisis for individuals or couples, little is known about the psychosexual aspects of infertility. On the basis that sexuality is a crucial part of quality of life, it is worthwhile to give more attention to sexuality of infertile couples during their time of experiencing infertility.

Precise Protein Photolithography (P): High Performance Biopatterning Using Silk Fibroin Light Chain as the Resist.

Precise patterning of biomaterials has widespread applications, including drug release, degradable implants, tissue engineering, and regenerative medicine. Patterning of protein-based microstructures using UV-photolithography has been demonstrated using protein as the resist material. The Achilles heel of existing protein-based biophotoresists is the inevitable wide molecular weight distribution during the protein extraction/regeneration process, hindering their practical uses in the semiconductor industry where reliability and repeatability are paramount.

HDAC6 serves as a biomarker for the prognosis of patients with renal cell carcinoma.

Background: Histone deacetylase 6 (HDAC6) is correlated with poor/better survival from cancers. This study was designed to investigate the correlation between HDAC6 expression and renal cell carcinoma (RCC) patients.

Methods: A total of 45 fresh RCC samples and 132 paraffin embedded tissues as well as their corresponding adjacent non-tumor tissues were collected by surgical excision.

Selective conversion of organic pollutant p-chlorophenol to formic acid using zeolite Fenton catalyst.

Effective remediation technologies which can converse the harmful organic pollutants to high-value chemicals are crucial both for wastewater treatment and energy regeneration. This study provides an evidence that extracting useful chemicals from wastewater is feasible through selective conversion of p-chlorophenol to high value formic acid as an example. The reported system works with a readily available Fe-containing ZSM-5 catalyst, water as the solvent and hydrogen peroxide as the oxidant.

Renal tubular injury induced by ischemia promotes the formation of calcium oxalate crystals in rats with hyperoxaluria.

Hyperoxaluria and cell injury are key factors in urolithiasis. Oxalate metabolism may be altered by renal dysfunction and therefore, impact the deposition of calcium oxalate (CaOx) crystals. We investigated the relationship of renal function, oxalate metabolism and CaOx crystal deposition in renal ischemia.

A pH-responsive and magnetically separable dynamic system for efficient removal of highly dilute antibiotics in water.

In order to control the antibiotic-related crisis and reduce the negative impacts on the environment and human health, it is urgent to develop effective technologies to eliminate residual antibiotics in water. Herein, we successfully fabricated a novel, pH-responsive and magnetically separable dynamic system for micropollutant adsorption and oxidation degradation in graphene oxide (GO)/nanoscale zero-valent iron (nZVI) composite with macroscopic structure. The pH-responsive self-assembly behavior of GO/nZVI composite was explored.

Upregulation of Nogo receptor expression induces apoptosis of retinal ganglion cells in diabetic rats.

The Nogo receptor is an essential factor for neuronal apoptosis, but the changes in Nogo receptor expression in the retina and the effects of the Nogo receptor on retinal ganglion cell apoptosis in diabetes mellitus remain unclear. We found that Nogo receptor expression was mainly visible in retinal ganglion cells of a rat model of diabetes mellitus induced by streptozotocin. At 12 weeks after onset of diabetes mellitus, Nogo receptor and Rho kinase expression significantly increased in the retina, and retinal ganglion cell apoptosis was apparent.

Degradation of the potential rodent contraceptive quinestrol and elimination of its estrogenic activity in soil and water.

Quinestrol has shown potential for use in the fertility control of the plateau pika population of the Qinghai-Tibet Plateau. However, the environmental safety and fate of this compound are still obscure. Our study investigated degradation of quinestrol in a local soil and aquatic system for the first time.

Oxidative removal of acetaminophen using zero valent aluminum-acid system: efficacy, influencing factors, and reaction mechanism.

Commercial available zero valent aluminum under air-equilibrated acidic conditions (ZVA1/H+/air system) demonstrated an excellent capacity to remove aqueous organic compounds. Acetaminophen (ACTM), the active ingredient of the over-the-counter drug Tylenol, is widely present in the aquatic environment and therefore the treatment of ACTM-contaminated water calls for further research. Herein we investigated the oxidative removal of ACTM by ZVA1/H+/air system and the reaction mechanism.

Efficient desulfurization by polymer-inorganic nanocomposite membranes fabricated in reverse microemulsion.

The sulfur in gasoline will convert to SO(2) after combustion under high temperature, which adversely affects human health and the environment. Membrane technique in particular pervaporation offers a number of potential advantages over conventional FCC gasoline desulfurization processes. The present study focuses on the performance enhancement of PDMS membrane by incorporating silica nanoparticles.

Oxidative removal of bisphenol A using zero valent aluminum-acid system.

Bisphenol A (BPA), a controversial endocrine disruptor, is ubiquitous in the aquatic environment. In this study, the oxidative degradation of BPA and its mechanism using zero valent aluminum (ZVAl)-acid system under air-equilibrated conditions was investigated. Under pH <3.

Additive antitumoral effect of interleukin-12 gene therapy and chemotherapy in the treatment of urothelial bladder cancer in vitro and in vivo.

Background: We evaluated antitumoral effect of combined chemotherapy and interleukin-12 (IL-12) gene therapy in in vitro and in vivo experimental urothelial bladder cancer (UBC) model.

Materials And Methods: EJ UBC cells were transfected with recombinant IL-12 genes using a liposomal transfection agent. Pirarubicin (THP) was added to the experimental samples at a final concentration of 20 mg/l.

Ultrathin and stable active layer of dense composite membrane enabled by poly(dopamine).

We demonstrate that dopamine is able to self-polymerize and adhere firmly onto the substrate, which can create a hierarchical structure comprising an ultrathin active layer and a porous support layer. Such an approach opens a novel way to fabricating highly efficient and stable composite materials including composite membranes. More specifically, in this study the composite membranes are fabricated by simply dipping microporous substrate in aqueous dopamine solution under mild conditions.