Risk factors for postoperative delirium in adult patients undergoing cardiopulmonary bypass in cardiac surgery.

Objective: To identify risk factors for postoperative delirium in adult patients undergoing cardiopulmonary bypass.

Methods: The medical records of 214 patients who underwent cardiopulmonary bypass at the First Affiliated Hospital of Hunan Normal University from January 2022 to January 2024 were retrospectively analyzed. Based on the occurrence of postoperative delirium, patients were divided into a delirium group (49 cases) and a non-delirium group (165 cases).

Dexmedetomidine alleviates hepatic injury via the inhibition of oxidative stress and activation of the Nrf2/HO-1 signaling pathway.

Dexmedetomidine (Dex), frequently used as an effective sedative, was reported to play a critical role in the protection of multiple organs. However, its underlying mechanism of a putative protective effect on ischemia/reperfusion (I/R)-induced liver injury is still unclear. A hepatocyte injury model was established by treating WRL-68 cells with oxygen and glucose deprivation/reoxygenation (OGD/R).

Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway.

Recently, α2-adrenoceptors (α2-AR) agonists have been shown to have anti-nociceptive effects and thus may become a promising therapeutic strategy for neuropathic pain. tizanidine is a highly selective α2-AR agonist, but the effect mechanism of tizanidine in neuropathic pain remains largely unknown. The present study investigated whether tizanidine has anti-nociceptive effects in spared nerve injury (SNI) model of neuropathic pain in rats, as well as explored the underlying molecular mechanism.

Temporary hyperlactataemia during partial hepatectomy: Report of two cases.

Lactic acidosis (LA) is characterized by accumulation of lactate in the body, and it may detrimentally affect homeostasis. Perioperative LA is rarely seen, here we presented 2 cases of patients suffered with temporary hyperlactataemia during partial hepatectomy, intended to emphasize that prolonged hypovolemia condition caused by controlled low central venous pressure, and overused hepatic vascular occlusion technique during parenchymal resection of hepatic surgery may seriously impact on the internal environment of patients. And we also discussed how to well manage long-time hepatectomy to prevent LA from occurring and to treat it appropriately.