Publications by authors named "Wanlu Sun"

Purpose: Asthma is a major public health challenge in China. Although chest pain variant asthma (CPVA) is not common in clinical practice, there are still a few people who only or mainly manifest as chest pain. Here, we aim to introduce the characteristics of their symptoms, lung function and chest imaging features to arouse the attention of physicians to know better of the disease.

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  • Photodynamic therapy (PDT) is a promising technique for tumor treatment, but faces issues with light penetration, selectivity, and efficient production of reactive oxygen species (ROS).
  • Researchers developed a new photosensitizer, NFh-NMe-2, which effectively generates singlet oxygen and induces cell death when exposed to 808 nm light.
  • An activatable photosensitizer, NFh-NTR, was also created to specifically target tumors by being activated in the presence of nitroreductase, enhancing effectiveness and safety in cancer treatment.
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Photodynamic therapy (PDT) is a promising anticancer method due to its noninvasive features, high efficiency, and superior accuracy. The activated near-infrared upconversion photosensitizer has a high tissue penetration depth and could be explicitly released with minimal side effects. Therefore, we designed and synthesized a series of Br-substituted compounds (NFh-Br) based on the near-infrared upconversion hemicyanine dye.

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Introduction: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnoea (OSA) are prevalent respiratory diseases in China and impose significant burdens on the healthcare system. Moreover, the co-occurrence of COPD and OSA exacerbates clinical outcomes significantly. However, comprehensive epidemiological investigations in China remain scarce, and the defining characteristics of the population affected by COPD and OSA, alongside their intrinsic relationship, remain ambiguous.

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The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the disease and fatality is valuable for future prevention and clinical treatment. We recruited 64 patients with invasive ventilation for COVID-19 and performed metatranscriptomic sequencing to profile host transcriptomic profiles, plus viral, bacterial, and fungal content, as well as virulence factors and examined their relationships to 28-day mortality were examined. In addition, the bronchoalveolar lavage fluid (BALF) samples from invasive ventilated hospital/community-acquired pneumonia patients (HAP/CAP) sampled in 2019 were included for comparison.

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As the organs responsible for toxin transformation and excretion in the body, damage to the liver and kidneys induced by inevitable drug toxicity is the main cause of acute liver and kidney injury. -Acetamidophenol overdose leads hypochlorous acid (HClO) to accumulate in the mitochondria of tissues, ultimately resulting in acute liver and kidney injury in humans, despite its clinical use as an antipyretic medicine. Herein, we report an HClO-activatable self-assembling ratiometric nanoprobe NRH-800-PEG for screening the upregulation of HClO by colocalization in mitochondria while monitoring the changes in the endogenous HClO levels in cells with ratiometric signals.

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Phototherapy has developed as a powerful method for remedial modalities. The conventional photosensitizers are "always on" state and lack tumor targeting, which contributed to poor therapeutic effect and high toxicity. Therefore, we developed an aspartyl aminopeptidase (DNPEP) activated self-assembled organic nanoparticles (NRh-Asp NPs) with sensitive external irradiation-induced photothermal therapy and photodynamic therapy (PTT/PDT).

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Objective: To explore the relationship between endogenous hydrogen sulfide (HS) and high-resolution computed tomography (HRCT) indexes in pulmonary vascular remodeling.

Methods: A total of 94 stable chronic obstructive pulmonary disease (COPD) patients were recruited for the study.Plasma HS levels were measured using fluorescence probe. Fluorescence quantitative polymerase chain reaction was used to measure HS synthase cystathionine-γ-lyase (CSE) mRNA and cystathionine-β-synthesis enzyme (CBS) mRNA.

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Background: Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by acute hypoxaemia, and few studies have reported the incidence of deep vein thrombosis (DVT) in direct ARDS caused by bacterial pneumonia. We performed a study to evaluate the prevalence, risk factors, prognosis and potential thromboprophylaxis strategies of DVT in these patients.

Methods: Ninety patients were included.

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  • This study investigates the characteristics and management of chronic obstructive pulmonary disease (COPD) patients in China's general population, focusing on spirometry-confirmed cases.
  • Among 9,134 COPD patients analyzed, 90.3% were classified as non-exacerbators, with a small percentage being frequent exacerbators or having asthma-COPD overlap, and less than 5% of non-exacerbators had undergone pulmonary function testing.
  • The usage rates of inhaled medication varied significantly among different groups, highlighting the need for a tailored management strategy for COPD in primary care settings.
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We report a mitochondria-targeted near-infrared probe (NRh-O) for frequency upconversion luminescence (FUCL) imaging of hypoxia. Under hypoxic conditions, NRh-O rapidly responds to release the FUCL product NRh (λ = 850/825 nm) with high sensitivity and selectivity in mitochondria. This highlights the potential application of a hypoxia-responsive probe in early clinical diagnosis.

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Purpose: To investigate whether hydrogen sulfide provide protective effects on atmosphere particulate matter (PM)-induced emphysema and airway inflammation and its mechanism.

Methods: Wild type C57BL/6 and Nrf2 knockout mice were exposed to PM (200 g per mouse). Hydrogen sulfide or propargylglycine were administered by intraperitoneal injection respectively 30 min before PM exposure, mice were anesthetized 29th day after administration.

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  • Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) often coexist, creating a condition known as overlap syndrome, which is linked to the development of pulmonary hypertension (PH).
  • A study involving 106 stable COPD patients evaluated the presence of OSA and its effects on pulmonary artery pressure (PAP) using home monitoring and echocardiography.
  • Results showed that patients with COPD and OSA had higher PAP compared to those without OSA, and factors like age and forced expiratory volume were significant contributors to PH development.
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Chronic liver disease is associated with lipid metabolic disruption. We carried out a study to determine serum lipidomic features of patients with non-alcoholic fatty liver disease (NAFLD) and active chronic hepatitis B (CHB) and explored the biomarkers for non-alcoholic steatohepatitis (NASH). Serum lipidomic profiles of healthy controls (n = 23) and of biopsy-proven NAFLD (n = 42), CHB with NAFLD (n = 22) and without NAFLD (n = 17) were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry.

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Aim: To investigate the association of PNPLA3 polymorphisms with concurrent chronic hepatitis B (CHB) and nonalcoholic fatty liver disease (NAFLD).

Methods: A cohort of Han patients with biopsy-proven CHB, with or without NAFLD (CHB group, n = 51; CHB + NAFLD group, n = 57), and normal controls (normal group, n = 47) were recruited from Northern (Tianjin), Central (Shanghai), and Southern (Zhangzhou) China. Their PNPLA3 polymorphisms were genotyped by gene sequencing.

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