Uncovering ZnS growth behavior and morphology control for high-performance aqueous Zn-S batteries.

Aqueous Zn-S batteries provide competitive energy density for large-scale energy storage systems. However, the cathode active material exhibits poor electrical conductivity especially at the discharged state of ZnS. Its morphology generated in cells thus directly determines the cathode electrochemical activity.

Tocilizumab Treatment in a Patient of Refractory Anti-EJ Positive ASyS: A Case Report.

Anti-synthetase syndrome (ASyS) is an autoimmune disease characterized by the presence of autoantibodies to aminoacyl-tRNA synthetases accompanied with various organ involvements, including the lung, joints, and skin. The ASyS-related interstitial lung disease (ILD) can be seen in the vast majority of patients. The extent of lung involvement has a significant impact on patient prognosis; the occurrence of rapid-progressive ILD could prominently increase mortality.

Anti-synthetase syndrome is associated with a higher risk of hospitalization among patients with idiopathic inflammatory myopathy and COVID-19.

Background: Data with fine granularity about COVID-19-related outcomes and risk factors were still limited in the idiopathic inflammatory myopathies (IIMs) population. This study aimed to investigate clinical factors associated with hospitalized and severe COVID-19 in patients with IIMs, particularly those gauged by myositis-specific antibodies.

Methods: This retrospective cohort study was conducted in the Renji IIM cohort in Shanghai, China, under an upsurge of SARS-CoV-2 omicron variant infections from December 2022 to January 2023.

Zinc-dual-halide complexes suppressing polyhalide formation for rechargeable aqueous zinc-halogen batteries.

Aqueous zinc-halogen batteries suffer from poor coulombic efficiency and short cycle life owing to the formation and dissolution of polyhalides in electrolytes. Herein, we apply a zinc-dual-halide complex strategy to confine free halides and suppress polyhalide formation. The high stabilities of zinc-dual-halide complexes are identified to be essential for effective confinement.

Ferroptosis signaling promotes the release of misfolded proteins via exosomes to rescue ER stress in hepatocellular carcinoma.

Dysfunction of the ubiquitin‒proteasome system can induce sustained endoplasmic reticulum stress (ERS) and subsequent cell death. However, malignant cells have evolved multiple mechanisms to evade sustained ERS. Therefore, identification of the mechanisms through which tumor cells develop resistance to ERS is important for the therapeutic exploitation of these cells for drug-resistant tumors.

Major infections in newly diagnosed systemic lupus erythematosus: an inception cohort study.

Objective: To evaluate the risk of major infections and the relationship between major infections and mortality in patients with newly diagnosed SLE.

Methods: A newly diagnosed (<3 months) hospitalised Systemic Lupus Inception Cohort (hSLIC) in our centre during 1 January 2013 and 1 November 2020 was established. All patients were followed up for at least 1 year or until death.

An Anti-Aromatic Covalent Organic Framework Cathode with Dual-Redox Centers for Rechargeable Aqueous Zinc Batteries.

Covalent organic frameworks (COFs) are promising cathode candidates with high structural stability. However, they contain redox inactive linkages and experience low redox potential. Herein, a full anti-aromatic microporous COF cathode material of TAQ-BQ is designed for aqueous zinc batteries.

Differences in sex- and age-associated mortality in patients with anti-MDA5-positive dermatomyositis.

Objectives: The effect of sex and age on the outcomes of patients with anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (MDA5+ DM) remains unclear. This study aimed to investigate the impact of sex and age on the prognosis of patients with MDA5+ DM.

Methods: We included 251 patients (women, 156; men, 95), who were newly diagnosed with MDA5+ DM between 2014 and 2021.

A High Potential Polyanion Cathode Material for Rechargeable Mg-Ion Batteries.

The development of Mg-ion batteries is hindered by the lack of cathode materials that allow facile and reversible Mg intercalation at high potential. Herein, the authors present a polyanion cathode material of K (VO) (HPO ) (C O )⋅4.5H O (KVPCH) for Mg-ion batteries.

Trisomy 8 Associated Clonal Cytopenia Featured With Acquired Auto-Inflammation and Its Response to JAK Inhibitors.

Objects: It has been recognized the nexus between trisomy 8 and auto-inflammatory features in myelodysplasia syndrome (MDS). Recent research about VEXAS syndrome proved clonal hematopoiesis could interfere with innate immune system far before occurrence of hematological malignancies. We reported a case series of clonal cytopenia with auto-inflammatory features in trisomy 8 patients.

The back-deposition of dissolved Mn to MnO cathodes for stable cycling in aqueous zinc batteries.

The Mn dissolution of MnO cathode materials causes rapid capacity decay in aqueous zinc batteries. We herein show that the dissolved Mn can be deposited back to the cathode with the aid of a suitable conductive agent. The active material is thus retained for energy storage, and this MnO/Mn redox process also provides capacity.

Spontaneous Intramuscular Hemorrhage in Anti-MDA5 Positive Dermatomyositis: A Case Series and Literature Review.

Objective: Spontaneous intramuscular hemorrhage (SIH) is a rare but life-threatening complication associated with dermatomyositis (DM). This study reported a case series of SIH associated with DM. In addition, the characteristics and prognostic effects for this complication were analyzed based on literature review.

Low Circulating Monocytes Is in Parallel With Lymphopenia Which Predicts Poor Outcome in Anti-melanoma Differentiation-Associated Gene 5 Antibody-Positive Dermatomyositis-Associated Interstitial Lung Disease.

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD) may progress rapidly and lead to high mortality within 6 or 12 months. Except for reported prognostic factors, simple but powerful prognostic biomarkers are still in need in practice. In this study, we focused on circulating monocyte and lymphocyte counts and their variation tendency in the early stage of ILD.

RNA-Containing Immune Complexes Formed by Anti-Melanoma Differentiation Associated Gene 5 Autoantibody Are Potent Inducers of IFN-α.

Objective: Anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody is a distinctive serology hallmark of dermatomyositis (DM). As an autoantigen, MDA5 is a cytoplasmic RNA recognition receptor. The aim of this study was to address the question of whether the RNA-containing immune complex (IC) formed by MDA5 and anti-MDA5 could activate type I interferon (IFN) response.

Description and Analysis of a Novel Subtype of the Anti-Synthetase Syndrome Characterized by Frequent Attacks of Fever and Systemic Inflammation in a Single-Center Cohort Study.

Objectives: The aim of this study was to investigate anti-synthetase syndrome (ASyS) patients who presented with recurrent episodes of fever and systemic inflammation.

Methods: A retrospective cohort of Chinese ASyS patients (n=126) in our center (between January 2013 and January 2020) was included. Patients presenting with concomitant autoimmune rheumatic diseases or malignancies were subsequently excluded.

A novel CT scoring method predicts the prognosis of interstitial lung disease associated with anti-MDA5 positive dermatomyositis.

Anti-melanoma differentiation-associated gene 5-positive dermatomyositis-associated interstitial lung disease (MDA5 DM-ILD) is a life-threatening disease. This study aimed to develop a novel pulmonary CT visual scoring method for assessing the prognosis of the disease, and an artificial intelligence (AI) algorithm-based analysis and an idiopathic pulmonary fibrosis (IPF)-based scoring were conducted as comparators. A retrospective cohort of hospitalized patients with MDA5 DM-ILD was analyzed.

A high capacity small molecule quinone cathode for rechargeable aqueous zinc-organic batteries.

Rechargeable aqueous zinc-organic batteries are promising energy storage systems with low-cost aqueous electrolyte and zinc metal anode. The electrochemical properties can be systematically adjusted with molecular design on organic cathode materials. Herein, we use a symmetric small molecule quinone cathode, tetraamino-p-benzoquinone (TABQ), with desirable functional groups to protonate and accomplish dominated proton insertion from weakly acidic zinc electrolyte.

Utility of fractional exhaled nitric oxide in interstitial lung disease.

The majority of interstitial lung diseases (ILDs) develop rapidly and are associated with a poor prognosis. Therefore, new noninvasive markers are needed to guide the classification and prognostication of ILD. We enrolled 95 patients with ILD, including dermatomyositis-associated ILD (69), Sjögren's syndrome-associated ILD (= 7), mixed connective tissue disease-associated ILD (= 9), idiopathic pulmonary fibrosis (= 5) and hypersensitivity pneumonitis (= 5), 82 patients with connective tissue disease but without ILD as well as 24 healthy controls, then evaluated fractional exhaled nitric oxide (FeNO50; 50 ml s) (Bisenkov20069-14), pulmonary function and high-resolution computed tomography (HRCT) scores.

The energy storage behavior of a phosphate-based cathode material in rechargeable zinc batteries.

The energy storage behavior of the Li3V2(PO4)3 cathode in zinc batteries is evaluated. The dissolution or decomposition into vanadium oxide in aqueous electrolytes is revealed. Using the optimal combination of water and acetonitrile solvents in electrolyte, those processes are effectively prevented without sacrificing the Zn2+ de/insertion kinetics.

Forced vital capacity predicts the survival of interstitial lung disease in anti-MDA5 positive dermatomyositis: a multi-centre cohort study.

Objectives: Anti-melanoma differentiation-associated gene 5 (MDA5) positive DM is a life-threatening disease often complicated with rapidly progressive interstitial lung disease (ILD). This study aimed to establish and validate a clinical prediction model for 6-month all-cause mortality in Chinese patients with anti-MDA5 positive DM-ILD.

Methods: We conducted a retrospective observational study using a single-centre derivation cohort and a multicentre validation cohort.

Interstitial Lung Disease in Anti-MDA5 Positive Dermatomyositis.

Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 DM) is a rare autoimmune disease predominantly reported in East Asia. MDA5 DM is an intractable disease with impressively high mortality due to rapid-progressive interstitial lung disease (RPILD). Other typical clinical manifestations comprise DM-specific rash (Gottron's papules, heliotrope rash) and amyopathic/hypomyopathic muscle involvement.