Can Intraoperative Low-Dose ,-Ketamine Prevent Depressive Symptoms After Surgery? The First Meta-Analysis of Clinical Trials.

Postoperative depression is a common complication after surgery that profoundly affects recovery and prognosis. New research indicates that (,)-ketamine is a potent antidepressant that exerts a rapid and sustained antidepressive effect. However, there is no consensus on whether intraoperative low-dose (,)-ketamine prevents postoperative depression.