Simulation of the continuous time random walk using subordination schemes.

The continuous time random walk model has been widely applied in various fields, including physics, biology, chemistry, finance, social phenomena, etc. In this work, we present an algorithm that utilizes a subordinate formula to generate data of the continuous time random walk in the long time limit. The algorithm has been validated using commonly employed observables, such as typical fluctuations of the positional distribution, rare fluctuations, the mean and the variance of the position, and breakthrough curves with time-dependent bias, demonstrating a perfect match.

Enhancing Crop Resilience: Insights from Labdane-Related Diterpenoid Phytoalexin Research in Rice ( L.).

Rice ( L.), as one of the most significant food crops worldwide, holds paramount importance for global food security. Throughout its extensive evolutionary journey, rice has evolved a diverse array of defense mechanisms to fend off pest and disease infestations.

Identification of ACAA1 and HADHB as potential prognostic biomarkers based on a novel fatty acid oxidation-related gene model in head and neck squamous cell carcinoma: A retrospective study.

Objectives: To investigate the importance of fatty acid oxidation (FAO)-related genes in predicting the progression and prognosis of head and neck squamous cell carcinoma (HNSCC).

Methods: The FAO-related gene prognostic model was established employing Cox regression analyses, during which accuracy and sensitivity of the gene model were evaluated in The Cancer Genome Atlas (TCGA) internal testing and Gene Expression Omnibus (GEO) external validation cohorts. Ultimately, hub genes were identified among 13 model genes using STRING and Cytoscape, with preliminary validation carried out through immunohistochemistry.

Deciphering adipose development: Function, differentiation and regulation.

The overdevelopment of adipose tissues, accompanied by excess lipid accumulation and energy storage, leads to adipose deposition and obesity. With the increasing incidence of obesity in recent years, obesity is becoming a major risk factor for human health, causing various relevant diseases (including hypertension, diabetes, osteoarthritis and cancers). Therefore, it is of significance to antagonize obesity to reduce the risk of obesity-related diseases.

Resolution of the reciprocity between radical species from precursor and closed pore formation in hard carbon for sodium storage.

Hard carbon (HC) has emerged as a highly promising anode material for sodium ion batteries, drawing tremendous interest in producing this material with low-cost and easily accessible precursors. The determination of the crucial parameters of precursors influencing the formation of key structures, such as closed pores, in the HC is of paramount importance. Considering the potential role of free radicals in the structural evolution of the precursors, we, for the first time, delve into the impact of radical species on the development of closed pores by electron paramagnetic resonance spectroscopy, with petroleum asphalt as the model system.

Hard Carbon Derived From Different Precursors for Sodium Storage.

Due to the almost unlimited resource and acceptable performance, Sodium-ion batteries (SIBs) have been regarded as a promising alternative for lithium-ion batteries (LIBs) for grid-scale energy storage. As the key material of SIBs, hard carbon (HC) plays a decisive role in determining the batteries' performance. Nevertheless, the micro-structure of HCs is quite complex and the random organization of turbostratically stacked graphene layers, closed pores, and defects make the structure-performance relationship insufficiently revealed.

Corydalis tomentella Franch. Exerts anti-inflammatory and analgesic effects by regulating the calcium signaling pathway.

Ethnopharmacological Relevance: Corydalis tomentella Franch. is a perennial cespitose plant commonly used to treat stomachaches as a folk medicine. The C.

Langevin picture of subdiffusion in nonuniformly expanding medium.

Anomalous diffusion phenomena have been observed in many complex physical and biological systems. One significant advance recently is the physical extension of particle's motion in a static medium to a uniformly and even nonuniformly expanding medium. The dynamic mechanism of the anomalous diffusion in the nonuniformly expanding medium has only been investigated by the approach of continuous-time random walk.

SPA-STOCSY: an automated tool for identifying annotated and non-annotated metabolites in high-throughput NMR spectra.

Motivation: Nuclear magnetic resonance spectroscopy (NMR) is widely used to analyze metabolites in biological samples, but the analysis requires specific expertise, it is time-consuming, and can be inaccurate. Here, we present a powerful automate tool, SPatial clustering Algorithm-Statistical TOtal Correlation SpectroscopY (SPA-STOCSY), which overcomes challenges faced when analyzing NMR data and identifies metabolites in a sample with high accuracy.

Results: As a data-driven method, SPA-STOCSY estimates all parameters from the input dataset.

Detection of the communicating accessory bile duct in laparoscopic resection of residual gallbladder by the combination of the indocyanine green fluorescence cholangiography and the intraoperative cholangiography: A case report.

Background: The partial cholecystectomy may be performed while in complicated laparoscopic cholecystectomy (LC). Biliary anomalies especially the accessory bile duct are established high risk of bile duct injury (BDI) in LC. Laparoscopic resection of residual gallbladder is a challenging procedure and extremely vulnerable to BDI.

scRNASequest: an ecosystem of scRNA-seq analysis, visualization, and publishing.

Background: Single-cell RNA sequencing is a state-of-the-art technology to understand gene expression in complex tissues. With the growing amount of data being generated, the standardization and automation of data analysis are critical to generating hypotheses and discovering biological insights.

Results: Here, we present scRNASequest, a semi-automated single-cell RNA-seq (scRNA-seq) data analysis workflow which allows (1) preprocessing from raw UMI count data, (2) harmonization by one or multiple methods, (3) reference-dataset-based cell type label transfer and embedding projection, (4) multi-sample, multi-condition single-cell level differential gene expression analysis, and (5) seamless integration with cellxgene VIP for visualization and with CellDepot for data hosting and sharing by generating compatible h5ad files.

Engineering chemical-bonded TiC MXene@carbon composite films with 3D transportation channels for promoting lithium-ion storage in hybrid capacitors.

Unlabelled: Lithium-ion capacitors (LICs) are promising energy storage devices because they feature the high energy density of lithium-ion batteries and the high power density of supercapacitors. However, the mismatch of electrochemical reaction kinetics between the anode and cathode in LICs makes exploring anode materials with fast ion diffusion and electron transfer channels an urgent task. Herein, the two-dimensional (2D) TiC MXene with controllable terminal groups was introduced into 1D carbon nanofibers to form a 3D conductive network by the electrospinning strategy.

NMRQNet: a deep learning approach for automatic identification and quantification of metabolites using Nuclear Magnetic Resonance (NMR) in human plasma samples.

Nuclear Magnetic Resonance is a powerful platform that reveals the metabolomics profiles within biofluids or tissues and contributes to personalized treatments in medical practice. However, data volume and complexity hinder the exploration of NMR spectra. Besides, the lack of fast and accurate computational tools that can handle the automatic identification and quantification of essential metabolites from NMR spectra also slows the wide application of these techniques in clinical.

SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra.

Nuclear Magnetic Resonance (NMR) spectroscopy is widely used to analyze metabolites in biological samples, but the analysis can be cumbersome and inaccurate. Here, we present a powerful automated tool, SPA-STOCSY (Spatial Clustering Algorithm - Statistical Total Correlation Spectroscopy), which overcomes the challenges by identifying metabolites in each sample with high accuracy. As a data-driven method, SPA-STOCSY estimates all parameters from the input dataset, first investigating the covariance pattern and then calculating the optimal threshold with which to cluster data points belonging to the same structural unit, i.

Design, synthesis and biological evaluation of novel 9-methyl-9H-purine and thieno[3, 2-d]pyrimidine derivatives as potent mTOR inhibitors.

The mammalian target of rapamycin (mTOR) has been proved to be an effective target for cancer therapy. Two kinds of mTOR inhibitors, the rapalogs and mTOR kinase inhibitors (TORKi), have been developed and clinically validated in several types of malignancies. Compared with rapalogs, TORKi can exert better antitumor activity by inhibiting both mTORC1 and mTORC2, but the clinical development of current TORKi candidates has been relative slow, more TORKi with novel scaffold need to be developed to expand the current pipelines.

Rose-like VS Nanosheets Chemically Anchored on Carbon Nanotubes for Flexible Zinc-Ion Batteries with Enhanced Properties.

Rechargeable aqueous zinc-ion batteries (ZIBs) are an attractive alternative for flexible energy storage devices due to their excellent safety and low cost. One of the main challenges that plagues their practical applications is the restricted variety of cathode materials with fast reaction kinetics and good mechanical properties. Herein, we prepared rose-like VS nanosheets which have decent specific capacities, metallic conductivity, and open-enough channels and further incorporated them into a single-walled carbon nanotube (SWCNT) network, achieving a C-V chemical-bonded freestanding VS@SWCNT (C-VS) composite.

First report of Leaf Spot Caused by Paramyrothecium foliicola on Tomato (Solanum lycopersicum) in China.

Tomato (Solanum lycopersicum) is a staple vegetable across the world. In October 2019, leaf spots were observed on tomato (cv. Tianmi) in a greenhouse in JiZhou District Tianjin, China(117°10 'E; 39°55 'N).

Infinite density and relaxation for Lévy walks in an external potential: Hermite polynomial approach.

Lévy walks are continuous-time random-walk processes with a spatiotemporal coupling of jump lengths and waiting times. We here apply the Hermite polynomial method to study the behavior of LWs with power-law walking time density for four different cases. First we show that the known result for the infinite density of an unconfined, unbiased LW is consistently recovered.

Influence of different pretreatments and drying methods on the chemical compositions and bioactivities of Smilacis Glabrae Rhizoma.

Background: The processing of medicinal plant materials is one of the important factors influencing the components and biological activities of TCMs. Smilax glabra Roxb. is an herbal vine widely distributed in China, and its dried rhizome (Smilacis Glabrae Rhizoma, SGR) is often used in traditional medicines and functional foods.

Production of low-oxygen oil via catalytic co-pyrolysis of biogas residue and plastics by ZSM-5.

This work aimed to produce low-oxygen bio-oil through the co-pyrolysis of biogas residue (BR) with polyethylene (PE) and polypropylene (PP). The effects of co-pyrolysis interactions on the kinetics and oxygen product distributions were studied. The kinetic results showed that the interaction of BR with PE in BR/PE blends decreased the apparent activation energy () in a range of 9.

Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor.

BRD4-targeted proteolysis targeting chimera (PROTAC) have exhibited promising in vitro and in vivo anticancer activity in a number of cancer models. However, the clinical development of current reported BRD4-PROTACs have stagnated, largely due to the safety risks caused by their poor degradation selectivity. In this study, we designed and synthesized a series of PROTACs based on our recently reported dual BET/PLK1 inhibitor WNY0824, which led to the discovery of an isoform-selective and potent BRD4-PROTAC 12a (WWL0245).

MiR-142-5p serves as a tumor suppressor in retinoblastoma cells by regulating MYCN.

Retinoblastoma is an intraocular malignant tumor and generally occurred in childhood. Here, we intended to appraise the functional influence of microRNA-142-5p (miR-142-5p) in retinoblastoma. MiR-142-5p was declined, and MYCN was upregulated in retinoblastoma tissues and cells.