A Comparison of Different Schemes of Neoadjuvant Chemotherapy Followed by Concurrent Chemotherapy and Radiotherapy for Locally Advanced Cervical Cancer: A Retrospective Study.

Purpose: To examine the clinical significance of unoperated cervical cancer patients treated with different neoadjuvant chemotherapy (NACT) schemes followed by concurrent chemotherapy and radiotherapy (CCRT).

Methods: This retrospective analysis included women with locally advanced cervical cancer treated with NACT-CCRT between September 2011 and September 2014. Neoadjuvant chemotherapy included paclitaxel plus cisplatin (TP group; 62 patients) or paclitaxel plus loplatin (TL group; 58 patients), which were administered three weekly, and cisplatin or loplatin, which were administered weekly for synchronous chemotherapy.

Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer's Disease Based on Systems Pharmacology.

Materials And Methods: In this study, a systems pharmacology-based strategy was used to elucidate the synergistic mechanism of Acori Tatarinowii Rhizoma and Codonopsis Radix for the treatment of AD. This novel systems pharmacology model consisted of component information, pharmacokinetic analysis, and pharmacological data. Additionally, the related pathways were compressed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, and the organ distributions were determined in the BioGPS bank.

Match Performance of Soccer Teams in the Chinese Super League-Effects of Situational and Environmental Factors.

To investigate the effects of situational factors (match location, strength of team and opponent) and environmental factors (relative air humidity, temperature and air quality index) on the technical and physical match performance of Chinese Soccer Super League teams (CSL). The generalized mixed modelling was employed to determine the effects by using the data of all 240 matches in the season 2015 collected by Amisco Pro. Increase in the rank difference would increase the number of goal-scoring related, passing and organizing related actions to a small-to-moderate extent (Effect size [ES]: 0.

Activity profiles of full-match and substitution players in the 2018 FIFA World Cup.

In order to better understand the intensity of match activities of full-match and substitution football players, running performance of 527 players who generated 1167 match observations in the 2018 FIFA World Cup were analysed. Differences in activity profiles between groups (1st and 2nd half full-match, early and late substitutes) were quantified by the generalised mixed linear modelling. Results showed that: (1) Full-match players presented trivial changes (ES: 0.

Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.

Breast cancer is one of the most prevalent types of cancer in women and contributes to 32% of all female cancer cases. Cathepsins, a family of proteins, are known to have a critical role in human cancers. However, previous studies on the systematic analysis of the role of cathepsin family members in breast cancer are limited.