Publications by authors named "Wankang Dian"
Cinnamaldehyde Alleviates Alveolar Epithelial Cell Injury in ALI by Inhibiting the CaMKII Pathway.
Cell Biochem Biophys
September 2024
Article Synopsis
- Alveolar epithelial cell injury is central to the severity of acute lung injury (ALI), and this study investigates the protective role of cinnamaldehyde (CA) on A549 cells exposed to lipopolysaccharide (LPS). !*
- CA treatment improved cell viability, reduced apoptosis, and lowered levels of inflammatory cytokines and oxidative stress markers in LPS-treated A549 cells, with minimal cytotoxic effects observed in the cells. !*
- The protective effects of CA were linked to the inhibition of the CaMKII pathway, as indicated by decreased levels of activated CaMKII and related proteins, suggesting CA as a potential therapeutic agent for reducing lung injury. !*
Linc00265, a long intergenic non-coding RNA, has garnered significant research attention due to its involvement in various human diseases, particularly cancer. It exhibits tissue-specific and dysregulated expression across multiple cancer types, including blood malignancies, colorectal, gastric, bladder, osteosarcoma, and hepatocellular carcinoma. This dysregulation is often associated with tumor aggressiveness, metastasis, and poor prognosis.
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- - The study investigates the effects of aminophylline (AP) on ventilator-induced diaphragmatic dysfunction (VIDD), which increases mortality and morbidity in patients needing mechanical ventilation. It focuses on the involvement of the IGF-1-FOXO1-MURF1 pathway in this dysfunction.
- - Rat models with VIDD were treated with mechanical ventilation, and various techniques (like lentiviral interference and western blot) were used to analyze protein and mRNA levels, diaphragm contractility, oxidative stress, and mitochondrial stability.
- - The findings aim to shed light on how AP might ameliorate VIDD and its associated mechanisms, including mitochondrial dynamics and apoptosis, which could lead to improved treatment strategies for patients requiring mechanical
Background: Mechanical ventilation (MV) sustains life in critically ill patients by providing adequate alveolar ventilation. However, prolonged MV could induce inspiratory muscle atrophy known as ventilator-induced diaphragmatic dysfunction (VIDD). Insulin-like growth factor () has been proven to play crucial roles in regulating skeletal muscle size and function.
View Article and Find Full Text PDFTo develop a C-reactive protein-to-albumin ratio (CAR)-based nomogram for predicting the risk of in-hospital death in sepsis patients. Sepsis patients were selected from the MIMIC-IV database. Independent predictors were determined by multiple Cox analysis and then integrated to predict survival.
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