Publications by authors named "Wanjing Lai"
Article Synopsis
- Current snakebite treatments depend on expensive antivenoms, but aptamers could be a viable alternative due to their ability to bind specific toxins.
- In this study, researchers focused on β-bungarotoxin from the Bungarus multicinctus snake, successfully developing an aptamer named BB3 through multiple rounds of optimization.
- The optimized BB3 aptamer showed lasting binding abilities, resistance to degradation, and significantly increased the survival time of mice poisoned with β-bungarotoxin, highlighting the potential for aptamers in future antivenom therapies.
Autism spectrum disorder (ASD) encompasses a range of neurodevelopmental conditions. Different mutations on a single ASD gene contribute to heterogeneity of disease phenotypes, possibly due to functional diversity of generated isoforms. SHANK2, a causative gene in ASD, demonstrates this phenomenon, but there is a scarcity of tools for studying endogenous SHANK2 proteins in an isoform-specific manner.
View Article and Find Full Text PDFBackground: Few articles have studied individuals with prediabetes after sleeve gastrectomy. Bile acid and lipid levels remain inconsistent in postbariatric patients. The purpose of this study was to explore bile acid, glucose, lipid, and liver enzyme changes in patients with different diabetes statuses who underwent sleeve gastrectomy.
View Article and Find Full Text PDFSHANK2 is a scaffold protein that serves as a protein anchor at the postsynaptic density in neurons. Genetic variants of SHANK2 are strongly associated with synaptic dysfunction and the pathophysiology of autism spectrum disorder. Recent studies indicate that early neuronal developmental defects play a role in the pathogenesis of autism spectrum disorder, and that insulin-like growth factor 1 has a positive effect on neurite development.
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