AIE luminogens based on 9, 10-dithienylanthracene with a D-A-D structure: Design, synthesis and application in cell imaging.

Three novel D-A-D-structured emitters derived from 9, 10-dithienylanthracene derivatives (DTAs) were synthesized and characterized. These DTAs consist of substituted 9-phenyl-9H-carbazole (BPCB-DTA), triphenylamine (BTPA-DTA) and N, N-dimethylaniline (BDMA-DTA) as donor units, with the phenylacetonitrile group serving as the acceptor. The impact of steric hindrance and electronic effect of the substituents on the optical properties has been thoroughly discussed.

[Investigation on intestinal nematode infections and their risk factors in Shanpo Sub-district, Jiangxia District, Wuhan City].

Objective: To investigate the infection status of intestinal nematodes and their risk factors in rural residents of Jiangxia District, Wuhan City, so as to provide the reference for the establishment of targeted prevention and control measures.

Methods: According to the requirements of cross-sectional study of the national human key parasitic diseases, the residents in Shanpo Sub-district, Jiangxia District were randomly selected as the objects for the investigation of the infection status of , hookworm and . A questionnaire survey was performed simultaneously.

Enhanced immune response and protection efficacy of a DNA vaccine constructed by linkage of the Mycobacterium tuberculosis Ag85B-encoding gene with the BVP22-encoding gene.

Plasmid DNA vaccines have been widely explored for use in tuberculosis immunization but their immunogenicity needs improvement. In the present study, we incorporated the bovine herpesvirus 1 VP22 (BVP22)-encoding gene, which encodes a protein that demonstrates a capability for disseminating the expressed antigen to neighbouring cells, into a DNA vector in which it was fused to the Ag85B-encoding gene of Mycobacterium tuberculosis (Mtb), and investigated whether this linkage could enhance immune response and protective efficacy in C57BL/6 mice compared to plasmid DNA encoding Ag85B alone. After immunization in mice, Ag85B-specific ELISA antibodies and spleen lymphocyte proliferative responses induced by DNA co-expressing BVP22 and Ag85B were significantly higher than those obtained in mice immunized with Ag85B-encoding DNA alone, except for the number of gamma interferon secreting cells.