Emerging Wearable Acoustic Sensing Technologies.

Sound signals not only serve as the primary communication medium but also find application in fields such as medical diagnosis and fault detection. With public healthcare resources increasingly under pressure, and challenges faced by disabled individuals on a daily basis, solutions that facilitate low-cost private healthcare hold considerable promise. Acoustic methods have been widely studied because of their lower technical complexity compared to other medical solutions, as well as the high safety threshold of the human body to acoustic energy.

Chitosan nanomedicines-engineered bifidobacteria complexes for effective colorectal tumor-targeted delivery of SN-38.

The clinical application of 7-ethyl hydroxy-camptothecin (SN-38) maintains challenges not only due to its poor solubility and stability but also the lack of effective carriers to actively deliver SN-38 to deep tumor sites. Although SN-38-based nanomedicines could improve the solubility and stability from different aspects, the tumor targeting efficiency remains very low. Leveraging the hypoxic taxis of bifidobacteria bifidum (B.

A Gas Flow Measurement System Based on Lead Zirconate Titanate Piezoelectric Micromachined Ultrasonic Transducer.

Ultrasonic flowmeter is one of the most widely used devices in flow measurement. Traditional bulk piezoelectric ceramic transducers restrict their application to small pipe diameters. In this paper, we propose an ultrasonic gas flowmeter based on a PZT piezoelectric micromachined ultrasonic transducer (PMUT) array.

Coherent Phonon Manipulation via Electron-Phonon Interaction for Facilitated Relaxation of Metastable Centers in ZnO.

Methods that allow versatile manipulation of metastable centers in semiconductors are highly important owing to their potential for quantum information processing and computations. In this study, we demonstrate that the electron-phonon interaction enables phonon participation to promote relaxation of metastable centers in ZnO, which is known for its persistent photoconductivity (PPC) effect. Experimentally, we show that continuous infrared (IR) radiation (1064 nm, ∼30 mW/cm) promotes longitudinal optical phonons via the Fröhlich interaction and increases the PPC relaxation rate by ∼4 folds.

Effects of Low- and High-Frequency Cardiac Rehabilitation on Risk Factors, Physical Fitness and Quality of Life in Middle-Aged Women with Coronary Heart Disease.

Cardiac rehabilitation (CR) is a system that comprehensively manages risk factors to reduce the recurrence rate after cardiovascular disease treatment. This study compared the effects of home-based low-frequency CR (1-2 times/week) and center-based high-frequency CR (3-5 times/week) for 12 weeks. This study was conducted as an observational case-control study.

Gold nanorods-loaded chitosan-based nanomedicine platform enabling an effective tumor regression in vivo.

The clinical utility of 7-ethyl-10-hydroxycamptothecin (SN-38) is hampered by its low water solubility and reduced bioactivity at neutral or alkaline conditions. The rational design of an effective drug delivery system that can significantly enhance the therapeutic index of SN-38 and achieve complete tumor regression still remains a challenge. Herein, chitosan-based hybrid nanoparticles system co-loading with chemotherapeutic drug SN-38 and gold nanorods (AuNRs) was engineered for effective combinational photothermal-chemotherapy.

Thermal Degradation Behavior of Thiol-ene Composites Loaded with a Novel Silicone Flame Retardant.

A novel silicone flame retardant PMDA was synthesized and blended with a commercial thiol-ene (TE) to obtain a flame-retardant TE (FRTE) composite. The cone calorimeter measurement showed the incorporation of PMDA improved the flame retardancy of the TE composite at concentrations of 5 wt%. The thermal stability and degradation mechanism of FRTE in nitrogen was studied by thermogravimetric analysis.

Research on Elastic-Plastic Contact Behavior of Hemisphere Flattened by a Rigid Flat.

The contact behavior of a hemisphere pressed by a rigid plane is of great significance to the study of friction, wear, and conduction between two rough surfaces. A flattening contact behavior of an elastic-perfectly plastic hemisphere pressed by a rigid flat is researched by using the finite element method in this paper. This behavior, influenced by different elastic moduli, Poisson's ratios, and yield strengths, is compared and analyzed in a large range of interference values, which have not been considered by previous models.

Probiotic NISSLE 1917 for inflammatory bowel disease applications.

NISSLE 1917 (EcN) is a Gram-negative strain with many prominent probiotic properties in the treatment of intestinal diseases such as diarrhea and inflammatory bowel disease (IBD), in particular ulcerative colitis. EcN not only exhibits antagonistic effects on a variety of intestinal pathogenic bacteria, but also regulates the secretion of immune factors and enhances the ability of host immunity. In this review, the mechanisms of EcN in the remission of inflammatory bowel disease are proposed and recent advances on the functionalized EcN are compiled to provide novel therapeutic strategies for the prevention and treatment of IBD.

A biocompatible superparamagnetic chitosan-based nanoplatform enabling targeted SN-38 delivery for colorectal cancer therapy.

7-Ethyl-10-hydroxycamptothecin (SN-38) as a potent anti-tumor candidate, suffers the constraints from its poor water solubility, pH-dependent lactone ring stability and the lack of efficient delivery system without losing its activity. Herein, biocompatible superparamagnetic chitosan-based nanocomplexes complexing with water-soluble polymeric prodrug poly(L-glutamic acid)-SN-38 (PGA-SN-38) was engineered for efficient delivery of SN-38. The manufacturing process of colloidal complexes was green, expeditious and facile, with one-shot addition of PGA-SN-38 into chitosan solution without using any organic solvent or surfactant.

Prevalence of Colorectal Polyps Based on Cardiorespiratory Fitness, Muscle Strength, Health Behavior, and Abdominal Obesity in Asymptomatic Elderly.

Colorectal polyps are precursor lesions of colorectal cancer and are known to be associated with obesity, low physical activity, and unhealthy behavior. This cross-sectional study analyzed the prevalence of colorectal polyps based on cardiorespiratory fitness (CRF), muscle strength, and health behavior in older adults. Participants were asymptomatic and included 1024 men and 472 women aged 65-80 years who visited the health care center.

Laser-Engineered Superhydrophobic Polydimethylsiloxane for Highly Efficient Water Manipulation.

Low-cost, high-quality, and large-area superhydrophobic surfaces are in high demand. This study demonstrates laser-engineered polydimethylsiloxane (PDMS) as a platform for versatile and highly efficient water manipulation. The fabrication process consists of two steps: patterning PDMS with arrayed microlenses and laser pulse scanning.

Highly Sensitive Uric Acid Detection Based on a Graphene Chemoresistor and Magnetic Beads.

In this study, we developed a low-cost, reusable, and highly sensitive analytical platform for the detection of the human metabolite uric acid (UA). This novel analysis platform combines the graphene chemoresistor detection technique with a magnetic bead (MB) system. The heterojunction (single-layer graphene and HfO thin-film material) of our graphene-based biosensor worked as a transducer to detect the pH change caused by the specific catalytic reaction between UA and uricase, and hence acquires a UA concentration.

Prevalence of Metabolic Syndrome According to Absolute and Relative Values of Muscle Strength in Middle-Aged and Elderly Women.

Metabolic syndrome (MetS) increases with age, obesity, low physical activity, and decreased muscle strength. Although many studies have reported on grip strength and MetS, few studies have been conducted on leg strength. The purpose of this study was to analyze the prevalence of MetS according to absolute and relative leg strength values in middle-aged and older women.

Optically Guided Pyroelectric Manipulation of Water Droplet on a Superhydrophobic Surface.

Controlled droplet manipulation by light has tremendous technological potential. We report here a method based on photothermally induced pyroelectric effects that enables manipulation and maneuvering of a water droplet on a superhydrophobic surface fabricated on lithium tantalite (LiTaO). In particular, we demonstrate that the pyroelectric charge distribution has an essential role in this process.

A Near-Infrared Laser-Triggered Size-Shrinkable Nanosystem with In Situ Drug Release for Deep Tumor Penetration.

The development of smart size-tunable drug delivery nanoplatform enables the solving of the paradox of inconsistent size-dependence of high tumor accumulation and deep penetration during its delivery process, thus achieving superior cancer treatment efficacy. Herein, we report a size-shrinkable nanomicelle complex system with an initial size of 101 nm enabling effective retention around the tumor periphery and could destruct to ultrasmall nanomicelles triggered by a near-infrared (NIR) laser to realize the deep tumor penetration. The nanomicelle system is consisted of an upper critical solution temperature (UCST)-type block copolymer poly(acrylamide-acrylonitrile)-polyethylene glycol-lipoic acid (p(AAm--AN)--PEG-LA) encapsulating gold nanorods.

Optically Induced Rapid Wetting Transition on Zn-Polar and O-Polar Zinc Oxide.

The design and fabrication of surfaces that support rapid wetting transition remain technologically challenging. Here, we examine the effects of optical illumination on the wetting behaviors of zinc oxide (ZnO) single crystals. We find that ultraviolet irradiation above the band gap energy promotes a rapid wetting transition, characterized by sliding of the water droplet, within a few seconds.