Publications by authors named "Wangli Zheng"
Toll-like receptor 8 (TLR8), an important innate immune receptor recognizing single stranded RNA and the antiviral imidazoquinoline compounds, can activate intracellular signaling pathway and produce an inflammatory response to kill and eliminate pathogens. However, the molecular regulation mechanisms of TLR8 signaling and its anti-infection activity are not fully elucidated. Our previous transcriptome analysis of porcine TLR8 (pTLR8) signaling suggested the immune checkpoint receptor TIM-3 as the potential regulator for pTLR8.
View Article and Find Full Text PDFcGAS is a cytosolic DNA sensor that activates innate immune responses by producing the second messenger 2'3'-cGAMP, which activates the adaptor STING. cGAS senses dsDNA in a length-dependent but sequence-independent manner, meaning it cannot discriminate self-DNA from foreign DNA. In normal physiological conditions, cellular DNA is sequestered in the nucleus by a nuclear envelope and in mitochondria by a mitochondrial membrane.
View Article and Find Full Text PDFFirst description of sp. and sp. infecting zoo animals in the Qinghai-Tibetan plateau area, China.
Front Cell Infect Microbiol
June 2023
Article Synopsis
- * A study conducted in the Qinghai-Tibetan Plateau involved collecting fecal samples from various animals to determine the presence and distribution of protozoan infections, revealing a positive rate of 12.6% in winter and 4.9% in summer samples.
- * This research is notable as it is the first to document specific protozoan infections in zoo animals from the region, enhancing understanding of potential zoonotic threats associated with wildlife.
Article Synopsis
- The study investigates the prevalence of Toxoplasma gondii, an intracellular parasite responsible for toxoplasmosis, in various food-borne animals across the Qinghai-Tibetan Plateau Area (QTPA).
- Using an indirect ELISA test based on recombinant SAG2 protein, researchers found that 44.1% of the animals tested had specific IgG antibodies, while 18.0% had IgM antibodies for the infection.
- The results revealed pigs showed the highest seropositivity for both IgG and IgM antibodies, with significant variations observed at different altitudes, highlighting the need for more control measures against T. gondii infections in the region.